Lack of association between the G681C polymorphism in the 5-HT1Dβ autoreceptor gene and schizophrenia

Arquivos de Neuro-Psiquiatria

Volumn 63, Issue 2 B, 2005, Pages 380-382

  Cordeiro, Quirino ^a   Vallada, Homero ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

5 HT1D ; G861C polymorphism; Genetic association; Schizophrenia

Indexed keywords

ATYPICAL ANTIPSYCHOTIC AGENT; AUTORECEPTOR; GENOMIC DNA; SEROTONIN; SEROTONIN 1D RECEPTOR;

AGE; ALLELE; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; DNA POLYMORPHISM; ETHNOLOGY; FEMALE; GENDER; GENETIC ASSOCIATION; GENOTYPE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; SCHIZOPHRENIA; SEROTONINERGIC SYSTEM;

EID: 21744451322     PISSN: 0004282X     EISSN: None     Source Type: Journal    
DOI: 10.1590/S0004-282X2005000300002     Document Type: Article

References (22)

1. McGuffin P, Owen MJ, O'Donovan MC, Thapar A, Gottesman I. Seminars in psychiatric genetics. London: Royal College of Psychiatrists, 1994.
2. Prasad S, Semwal P, Deshpande S, Bhatia T, Nimgaonkar VL, Telma BK. Molecular genetics of schizophrenia: past, present and future. J Biosci 2002;27:35-52.
3. Stahl SM, Wets K. Neurochemistry and neuropharmacology of schizophrenia. London: Elsevier, 1987.
4. Joyce JN, Shane A, Lexow N, Winokur A, Casanova MF, Kleinman JE. Serotonin uptake sites and serotonin receptors are altered in the limbic system of schizophenics. Neuropsychopharmacology 1993;8315-8336.
5. Kapur S, Remington G. Serotonin-dopamine interaction and its relevance to schizophrenia. Am J Psychiatry 1996;153:466-476.
6. Barnes NM, Sharp T. A review of central 5-HT receptors and their function. Neuropharmacology 1999;38:1083-1152.
7. Hamblin MW, Metcalf MA. Primary structure and functional characterization of a human 5T1D-type serotonin receptor. Mol Pharmacol 1991; 40:143-148.
8. Demchyshyn L, Sunahara R, Miller K, et al. A human serotonin 1D receptor variant (5HT1Dβ) encoded by an intronless gene on chromosome 6. Proc Natl Acad Sci USA 1992;89:5522-5526.
9. Weinshank RL, Zgombick JM, Maccihi MJ, Branchek TA, Harting PR. Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta. Proc Natl Acad Sci USA 1992;89:3630-3634.
10. Jin H, Oksenberg D, Askhenazi A, et al. Characterization of human 5-hydroxytryptamine1B receptor. J Biol Chem 1992;267:5735-5738.
11. Martinez M, Goldi L, Cao Q, et al. Follow-up study on a susceptibility locus for schizophrenia on chromosome 6q. Am J Med Genet 1999;83:337-343.
12. Hwu H-G, Lin M-W, Lee P-C, Lee F-C, Ou-Yang W-C, Liu C-M. Evaluation of linkage of markers on chromosome 6p with schizophrenia in Taiwanese families. Am J Med Genet 2000;96:74-78.
13. Baron M. Genetics of schizophrenia and the new millennium: progress and pitfalls. Am J Hum Genet 2001;68:299-312.
14. Lander ES. The new genomics: global views of biology. Science 1996; 274:1594-1595.
15. Collins FS, Guyer MS, Chakravarti A. Variations on the theme: cataloging human DNA sequence variation. Science 1997;278:1580-1581.
16. American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 4th ed. Washington, DC: American Psychiatric Association, 1994.
17. Lappalainen J, Dean M, Charbonneau L, Virkkunen M, Linnoila M, Goldman D. Mapping of the serotonin 5-HT1Dβ autoreceptor gene on chromosome 6 and direct analysis for sequence variants. Am J Med Genet 1995;60:157-161.
18. Shan P. Statistics in human genetics. New York: Arnold, 1998.
19. Sidenberg DG, Basset AS, Demchyshyn L, et al. New polymorphism for human serotonin ID receptor variant (5-HT1Dβ) not linked to schizophrenia in five Canadian pedigrees. Hum Hered 1993;43:315-318.
20. Coelho I, Macedo A, Valente J, et al. Association study of serotonin receptors and schizophrenia in a portuguese population. Psiquiatria Clínica 1997;18:41-47.
21. Ambrósio AM, Kennedy JL, Macciardi F, et al. Lack of association or linkage disequilibrium between schizophrenia and polymorphisms in the 5-HT1DA and 5-HT1DB autoreceptor genes: family-based association study. Am J Med Genet 2004;128:1-5.
22. Parra FC, Amado RC, Lambertucci JR, Rocha J, Antunes CM, Pena SD. Color and genomic ancestry in Brazilians. Proc Natl Acad Sci U S A 2003;100:177-182.