Epidemiology of nosocomial infections due to Pseudomonas aeruginosa, Burkholderia cepacia and Stenotrophomonas maltophilia;Épidémiologie des infections nosocomiales à Pseudomonas aeruginosa, Burkholderia cepacia et Stenotrophomonas maltophilia

Pathologie Biologie

Volumn 53, Issue 6, 2005, Pages 341-348

  Berthelot, P ^a   Grattard, F ^a   Mallaval, F O ^a   Ros, A ^a   Lucht, F ^a   Pozzetto, B ^a  

^a UNIVERSITY HOSPITAL OF SAINT ETIENNE   (France)

Author keywords

Burkholderia cepacia; Epidemiology; Gram negative non fermentative rods; Nosocomial infection; Pseudomonas aeruginosa; Stenotrophomonas maltophilia

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; BETA LACTAM ANTIBIOTIC; CEPHALOSPORIN; CHLORHEXIDINE; CIPROFLOXACIN; DISINFECTANT AGENT; IMIPENEM; PENICILLIN G; POVIDONE IODINE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; VIRULENCE FACTOR;

ANTIBIOTIC SENSITIVITY; BACTERIAL PNEUMONIA; BACTERIAL STRAIN; BACTERIAL TRANSMISSION; BURKHOLDERIA CEPACIA; DEVICE; DISEASE SEVERITY; DISINFECTION; GENOTYPE; HOSPITAL INFECTION; HUMAN; LETHALITY; MORTALITY; PHENOTYPE; PSEUDOMONAS AERUGINOSA; REVIEW; SEROTYPE; STENOTROPHOMONAS MALTOPHILIA; BACTERIAL INFECTION; CROSS INFECTION; DISEASE TRANSMISSION; GRAM NEGATIVE INFECTION;

BURKHOLDERIA CEPACIA; BURKHOLDERIA INFECTIONS; CROSS INFECTION; GRAM-NEGATIVE BACTERIAL INFECTIONS; HUMANS; PSEUDOMONAS INFECTIONS; STENOTROPHOMONAS MALTOPHILIA;

EID: 21744449475     PISSN: 03698114     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.patbio.2004.09.006     Document Type: Short Survey

References (99)

1. M.O. Husson, M. Hamze, S. Verhille, and D. Izard Pseudomonas et burkholderia J. Freney Pŕcis de bact́riologie clinique 2000 ESKA Paris 1259 1283
2. W.R. Jarvis, and W.J. Martone Predominant pathogens in hospital infections J. Antimicrob. Chemother. 29 Suppl A 1992 19 24
3. P. Hirsch Microbial life at extremely low nutrient levels Adv. Space Res. 6 12 1986 287 298
4. G. Doring, M. Horz, J. Ortelt, H. Grupp, and C. Wolz Molecular epidemiology of Pseudomonas aeruginosa in an intensive care unit Epidemiol. Infect. 110 3 1993 427 436
5. D.J. Weber, W.A Rutala, C.N. Blanchet, M. Jordan, and M.F. Gergen Faucet aerators: A source of patient colonization with Stenotrophomonas maltophilia Am. J. Infect. Control 27 1 1999 59 63
6. P.E. Verweij, J.F. Meis, and V. Christmann Nosocomial outbreak of colonization and infection with Stenotrophomonas maltophilia in preterm infants associated with contaminated tap water Epidemiol. Infect. 120 3 1998 251 256
7. Y.F. Berrouane, L.A. McNutt, and B.J. Buschelman Outbreak of severe Pseudomonas aeruginosa infections caused by a contaminated drain in a whirlpool bathtub Clin. Infect. Dis. 31 6 2000 1331 1337
8. N.A. Cobben, M. Drent, M. Jonkers, E.F. Wouters, M Vaneechoutte, and E.E. Stobberingh Outbreak of severe Pseudomonas aeruginosa respiratory infections due to contaminated nebulizers J. Hosp. Infect. 33 1 1996 63 70
9. A.C. Reboli, R. Koshinski, K. Arias, K. Marks-Austin, D. Stieritz, and T.L. Stull An outbreak of Burkholderia cepacia lower respiratory tract infection associated with contaminated albuterol nebulization solution Infect. Control Hosp. Epidemiol. 17 11 1996 741 743
10. Y. Hirai Survival of bacteria under dry conditions; from a viewpoint of nosocomial infection J. Hosp. Infect. 19 3 1991 191 200
11. K. Botzenhart, and H. Ruden Hospital infections caused by Pseudomonas aeruginosa Antibiot. Chemother. 39 1987 1 15
12. V. Jarlier, T. Fosse, and A. Philippon Antibiotic susceptibility in aerobic gram-negative bacilli isolated in intensive care units in 39 French teaching hospitals (ICU study) Intensive Care Med. 22 10 1996 1057 1065
13. A. Holmes, R. Nolan, and R Taylor An epidemic of Burkholderia cepacia transmitted between patients with and without cystic fibrosis J. Infect. Dis. 179 5 1999 1197 1205
14. E.E. Tredget, H.A. Shankowsky, and A.M. Joffe Epidemiology of infections with Pseudomonas aeruginosa in burn patients: the role of hydrotherapy Clin. Infect. Dis. 15 6 1992 941 949
15. H.J. Kolmos, B. Thuesen, S.V. Nielsen, M. Lohmann, K. Kristoffersen, and V.T. Rosdahl Outbreak of infection in a burns unit due to Pseudomonas aeruginosa originating from contaminated tubing used for irrigation of patients J. Hosp. Infect. 24 1 1993 11 21
16. P. Berthelot, F. Grattard, and P. Mahul Prospective study of nosocomial colonization and infection due to Pseudomonas aeruginosa in mechanically ventilated patients Intensive Care Med 27 3 2001 503 512
17. S. Schelenz, and G. French An outbreak of multidrug-resistant Pseudomonas aeruginosa infection associated with contamination of bronchoscopes and an endoscope washer-disinfector J. Hosp. Infect. 46 1 2000 23 30
18. M. Sorin, S. Segal-Maurer, N. Mariano, C. Urban, A. Combest, and J.J. Rahal Nosocomial transmission of imipenem-resistant Pseudomonas aeruginosa following bronchoscopy associated with improper connection to the Steris System 1 processor Infect. Control. Hosp. Epidemiol. 22 7 2001 409 413
19. M.J. Struelens, F. Rost, and A. Deplano Pseudomonas aeruginosa and Enterobacteriaceae bacteremia after biliary endoscopy: an outbreak investigation using DNA macrorestriction analysis Am. J. Med. 95 5 1993 489 498
20. J.J. Weems Jr. Nosocomial outbreak of Pseudomonas cepacia associated with contamination of reusable electronic ventilator temperature probes Infect. Control Hosp. Epidemiol. 14 10 1993 583 586
21. S. Vassal, R. Taamma, and N. Marty Microbiologic contamination study of nebulizers after aerosol therapy in patients with cystic fibrosis Am. J. Infect. Control 28 5 2000 347 351
22. A.S. Cross, and B. Roup Role of respiratory assistance devices in endemic nosocomial pneumonia Am. J. Med. 70 3 1981 681 685
23. P. Berthelot, F. Grattard, and P. Mahul Ventilator temperature sensors: an unusual source of Pseudomonas cepacia in nosocomial infection J. Hosp. Infect. 25 1 1993 33 43
24. R.P. Aduan, P.B. Iannini, and J. Salaki Nosocomial bacteremia associated with contaminated blood pressure transducers: report of an outbreak and a review of the literature Am. J. Infect. Control 8 2 1980 33 40
25. C.M. Beck-Sague, and W.R. Jarvis Epidemic bloodstream infections associated with pressure transducers: a persistent problem Infect. Control Hosp. Epidemiol. 10 2 1989 54 59
26. M.W. Climo, A. Pastor, and E.S. Wong An outbreak of Pseudomonas aeruginosa related to contaminated urodynamic equipment Infect. Control Hosp. Epidemiol. 18 7 1997 509 510
27. M. Cruciani, M. Malena, G. Amalfitano, P. Monti, and L. Bonomi Molecular epidemiology in a cluster of cases of postoperative Pseudomonas aeruginosa endophthalmitis Clin. Infect. Dis. 26 2 1998 330 333
28. J.P. Flaherty, S Garcia-Houchins, R. Chudy, and P.M. Arnow An outbreak of gram-negative bacteremia traced to contaminated O-rings in reprocessed dialyzers Ann. Intern. Med. 119 11 1993 1072 1078
29. S.M. Garland, S. Mackays, S. Tabrizi, and S. Jacobs Pseudomonas aeruginosa outbreak associated with a contaminated blood-gas analyser in a neonatal intensive care unit J. Hosp. Infect. 33 2 1996 145 151
30. G.W. Yardy, and R.A. Cox An outbreak of Pseudomonas aeruginosa infection associated with contaminated urodynamic equipment J Hosp Infect 47 1 2001 60 63
31. J.P. Buttery, S.J Alabaster, and R.G. Heine Multiresistant Pseudomonas aeruginosa outbreak in a pediatric oncology ward related to bath toys Pediatr. Infect. Dis. J. 17 6 1998 509 513
32. D.L. Kirschle, T.F. Jones, and A.S. Craig Pseudomonas aeruginosa and Serratia marcesecens contamination associated with a manufacturing defect in bronchoscopes N. Engl. J. Med. 348 2002 214 220
33. A. Srinivasan, L.L. Wolfenden, and X. Song An outbreak of Pseudomonas aeruginosa infections associated with flexible bronchoscopes N. Engl. J. Med. 348 2002 221 227
34. W. Swaddiwudhipong, T. Tangkitchot, and N. Silarug An outbreak of Pseudomonas aeruginosa postoperative endophthalmitis caused by contaminated intraocular irrigating solution Trans R. Soc. Trop. Med. Hyg. 89 3 1995 288
35. W. Forman, P. Axelrod, and K. ST John Investigation of a pseudo-outbreak of orthopedic infections caused by Pseudomonas aeruginosa Infect. Control Hosp. Epidemiol. 15 10 1994 652 657
36. A.H. Ramsey, P. Skonieczny, D.T. Coolidge, T.A. Kurzynski, M.E. Proctor, and J.P. Davis Burkholderia cepacia lower respiratory tract infection associated with exposure to a respiratory therapist Infect. Control Hosp. Epidemiol. 22 7 2001 423 426
37. F. Van Laer, D. Raes, and P. Vandamme An outbreak of Burkholderia cepacia with septicemia on a cardiology ward Infect. Control Hosp. Epidemiol. 19 2 1998 112 113
38. D. Gravel, M.L. Sample, K. Ramotor, B. Toye, C. Oxley, and G. Garber Outbreak of Burkholderia cepacia in the adult intensive care unit traced to contaminated indigo-carmine dye Infect. Control Hosp. Epidemiol. 23 2 2002 103 106
39. L. Matrician, G. Ange, and S. Burns Outbreak of nosocomial Burkholderia cepacia infection and colonization associated with intrinsically contaminated mouthwash Infect. Control Hosp. Epidemiol. 21 11 2000 739 741
40. J.R. Rudnick, C.M. Beck-Sague, R.L. Anderson, B. Schable, J.M. Miller, and W.R. Jarvis Gram-negative bacteremia in open-heart-surgery patients traced to probable tap-water contamination of pressure-monitoring equipment Infect. Control Hosp. Epidemiol. 17 5 1996 281 285
41. M. Foca, K. Jakob, and S. Whittier Endemic Pseudomonas aeruginosa infection in a neonatal intensive care unit N. Engl. J. Med. 343 10 2000 695 700
42. S.A. McNeil, L. Nordstrom-Lerner, P.N. Malani, M. Zervos, and C.A. Kauffman Outbreak of sternal surgical site infections due to Pseudomonas aeruginosa traced to a scrub nurse with onychomycosis Clin. Infect. Dis. 33 3 2001 317 323
43. R.L. Moolenaar, J.M. Crutcher, and V.H. San Joaquin A prolonged outbreak of Pseudomonas aeruginosa in a neonatal intensive care unit: did staff fingernails play a role in disease transmission? Infect. Control Hosp. Epidemiol. 21 2 2000 80 85
44. J.D. Klausner, C. Zukerman, A.P. Limaye, and L. Corey Outbreak of Stenotrophomonas maltophilia bacteremia among patients undergoing bone marrow transplantation: association with faulty replacement of handwashing soap Infect. Control Hosp. Epidemiol. 20 11 1999 756 758
45. V.E. Becks, and N.M. Lorenzoni Pseudomonas aeruginosa outbreak in a neonatal intensive care unit: a possible link to contaminated hand lotion Am. J. Infect. Control 23 6 1995 396 398
46. A. Ferroni, L. Nguyen, B. Pron, G. Quesne, M.C. Brusset, and P. Berche Outbreak of nosocomial urinary tract infections due to Pseudomonas aeruginosa in a paediatric surgical unit associated with tap-water contamination J. Hosp. Infect. 39 4 1998 301 307
47. F. Bert, E. Maubec, P. Berry, and N. Lambert-Zechovsky Multi-resistant Pseudomonas aeruginosa outbreak associated with contaminated tap water in a neurosurgery intensive care unit J. Hosp. Infect. 39 1 1998 53 62
48. A.F. Widmer, R.P. Wenzel, A. Trilla, M.J. Bale, R.N. Jones, and B.N. Doebbeling Outbreak of Pseudomonas aeruginosa infections in a surgical intensive care unit: probable transmission via hands of a health care worker Clin. Infect. Dis. 16 3 1993 372 376
49. D.A. Pegues, L.A. Carson, and O.C. Tablan Acquisition of Pseudomonas cepacia at summer camps for patients with cystic fibrosis. Summer Camp Study Group J. Pediatr. 124 5 Pt 1 1994 694 702
50. S.J. McCallum, J. Corkill, M. Gallagher, M.J. Ledson, C.A. Hart, and M.J. Walchaw Superinfection with a transmissible strain of Pseudomonas aeruginosa in adults with cystic fibrosis chronically colonised by P.:aeruginosa Lancet 358 9281 2001 558 560
51. P.E. Verweij, D. Bijl, and W.J. Melchers Pseudo-outbreak of multiresistant Pseudomonas aeruginosa in a hematology unit Infect. Control Hosp. Epidemiol. 18 2 1997 128 131
52. o sṕcial 1998 134 149
53. T. Kohler, J.C. Pechere, and P. Plesiat Bacterial antibiotic efflux systems of medical importance Cell. Mol. Life Sci. 56 1999 771 778
54. X. Bertrand, P. Bailly, G. Blasco, P. Balvay, A. Boillot, and D. Talon Large outbreak in a surgical intensive care unit of colonization or infection with Pseudomonas aeruginosa that overexpressed an active efflux pump Clin. Infect. Dis. 31 4 2000 E9 E14
55. M.J. Bonten, D.C. Bergmans, H. Speijer, and E.E. Stobberingh Characteristics of polyclonal endemicity of Pseudomonas aeruginosa colonization in intensive care units. Implications for infection control Am. J. Respir. Crit. Care Med. 160 4 1999 1212 1219
56. M.J. Bonten, D.J. Austin, and M. Lipsitch Understanding the spread of antibiotic resistant pathogens in hospitals: mathematical models as tools for control Clin. Infect. Dis. 33 10 2001 1739 1746
57. A.S. Prince Biofilms, antimicrobial resistance, and airway infection N. Engl. J. Med. 347 14 2002 1110 1111
58. E. Drenkard, and F.M. Ausubel Pseudomonas biofilm formation and antibiotic resistance are linked to phenotypic variation Nature 416 2002 740 743
59. A.L. Panlilio, C.M. Beck-Sague, and J.D. Siegel Infections and pseudoinfections due to povidone-iodine solution contaminated with Pseudomonas cepacia Clin. Infect. Dis. 14 5 1992 1078 1083
60. M.M. Wishart, and T.V. Riley Infection with Pseudomonas maltophilia hospital outbreak due to contaminated disinfectant Med. J. Aust. 2 19 1976 710 712
61. A.H. Siddiqui, M.E. Mulligan, and E. Mahenthiralingam An episodic outbreak of genetically related Burkholderia cepacia among non-cystic fibrosis patients at a university hospital Infect. Control Hosp. Epidemiol. 22 7 2001 419 422
62. D.P. Speert Molecular epidemiology of Pseudomonas aeruginosa Front Biosci 7 2002 e354 e361
63. C.S. Rabkin, W.R. Jarvis, and R.L. Anderson Pseudomonas cepacia typing systems: collaborative study to assess their potential in epidemiologic investigations Rev. Infect. Dis. 11 4 1989 600 607
64. P.T. Tassios, V. Gennimata, and L. Spaliara-Kalogeropoulou Multiresistant Pseudomonas aeruginosa serogroup O:11 outbreak in an intensive care unit Clin. Microbiol. Infect. 3 6 1997 621 628
65. C.K. Stover, X.Q. Pham, and A.L. Erwin Complete genome sequence of Pseudomonas aeruginosa PA01, an opportunistic pathogen Nature 406 6799 2000 959 964
66. C.K. Raymond, E.H. Sims, and A. Kas Genetic variation at the O-antigen biosynthetic locus in Pseudomonas aeruginosa J. Bacteriol. 184 13 2002 3614 3622
67. T.L. Pitt Epidemiological typing of Pseudomonas aeruginosa Eur. J. Clin. Microbiol. Infect. Dis. 7 2 1988 238 247
68. F. Grattard, O.G. Gaudin, B. Pozzetto, A. Ros, and A.D. Mbida Genotypic homogeneity of nosocomial Pseudomonas aeruginosa O12 strains demonstrated by analysis of protein profiles, DNA fingerprints and rRNA gene restriction patterns Eur. J. Clin. Microbiol. Infect. Dis. 12 1 1993 57 61
69. S. Brisse, D. Milatovic, and A.C. Fluit Molecular surveillance of European quinolone-resistant clinical isolates of Pseudomonas aeruginosa and Acinetobacter sp. using automated ribotyping J. Clin. Microbiol. 38 10 2000 3636 3645
70. F.C. Tenover, R.D. Arbeit, and R.V. Goering How to select and interpret molecular strain typing methods for epidemiological studies of bacterial infections: a review for healthcare epidemiologists. Molecular Typing Working Group of the Society for Healthcare Epidemiology of America Infect. Control Hosp. Epidemiol. 18 6 1997 426 439
71. M.J. Struelens, V. Schwam, A. Deplano, and D. Baran Genome macrorestriction analysis of diversity and variability of Pseudomonas aeruginosa strains infecting cystic fibrosis patients J. Clin. Microbiol. 31 9 1993 2320 2326
72. E.H. Bingen, M. Weber, and J. Derelle Arbitrarily primed polymerase chain reaction as a rapid method to differentiate crossed from independent Pseudomonas cepacia infections in cystic fibrosis patients J. Clin. Microbiol. 31 10 1993 2589 2593
73. N. Marty Epidemiological typing of Stenotrophomonas maltophilia J. Hosp. Infect. 36 4 1997 261 266
74. M. Okazaki, T. Watanabe, and K. Morita Molecular epidemiological investigation using a randomly amplified polymorphic DNA assay of Burkholderia cepacia isolates from nosocomial outbreaks J. Clin. Microbiol. 37 12 1999 3809 3814
75. E. Bingen, S. Bonacorsi, and P. Rohrlich Molecular epidemiology provides evidence of genotypic heterogeneity of multidrug-resistant Pseudomonas aeruginosa serotype O:12 outbreak isolates from a pediatric hospital J. Clin. Microbiol. 34 12 1996 3226 3229
76. X. Bertrand, M. Thouverez, and D. Talon Endemicity, molecular diversity and colonisation routes of Pseudomonas aeruginosa in intensive care units Intensive Care Med 27 8 2001 1263 1268
77. D.S. Blanc, C. Petignat, B. Janin, J. Bille, and P. Francioli Frequency and molecular diversity of Pseudomonas aeruginosa upon admission and during hospitalization: a prospective epidemiologic study Clin. Microbiol. Infect. 4 5 1998 242 247
78. L. Ostrosky-Zeichner, R. Baez-Martinez, M.S. Rangel-Frausto, and S. Ponce-de-Leon Epidemiology of nosocomial outbreaks: 14-year experience at a tertiary-care center Infect. Control Hosp. Epidemiol. 21 8 2000 527 529
79. A. Mangram, and W.R. Jarvis Nosocomial Burkholderia cepacia outbreaks and pseudo-outbreaks Infect. Control Hosp. Epidemiol. 17 11 1996 718 720
80. N. Alfieri, K. Ramotar, and P. Armstrong Two consecutive outbreaks of Stenotrophomonas maltophilia(Xanthomonas maltophilia) in an intensive-care unit defined by restriction fragment-length polymorphism typing Infect. Control Hosp. Epidemiol. 20 8 1999 553 556
81. F.L. Pellegrino, L.M. Teixeira, and G. Carvalho Md Mda Occurrence of a multidrug-resistant Pseudomonas aeruginosa clone in different hospitals in Rio de Janeiro, Brazil J. Clin. Microbiol. 40 7 2002 2420 2424
82. D. Talon, B. Mulin, C. Rouget, P. Bailly, M. Thouverez, and J.F. Viel Risks and routes for ventilator-associated pneumonia with Pseudomonas aeruginosa Am. J. Respir. Crit. Care Med. 157 3 Pt 1 1998 978 984
83. J. Rello, D. Mariscal, and F. March Recurrent Pseudomonas aeruginosa pneumonia in ventilated patients: relapse or reinfection? Am. J. Respir. Crit. Care Med. 157 3 Pt 1 1998 912 916
84. P. Berthelot, F. Grattard, and H. Patural Nosocomial colonization of premature babies with Klebsiella oxytoca: probable role of enteral feeding procedure in transmission and control of the outbreak with the use of gloves Infect. Control Hosp. Epidemiol. 22 3 2001 148 151
85. M.K. Waldor Bacteriophage biology and bacterial virulence Trends Microbiol. 6 8 1998 295 297
86. F.D. Sottile, T.J. Marrie, and D.S. Prough Nosocomial pulmonary infection: possible etiologic significance of bacterial adhesion to endotracheal tubes Crit. Care Med. 14 4 1986 265 270
87. L.A. Mermel, B.M. Farr, and R.J. Sherertz Guidelines for the management of intravascular catheter-related infections Clin. Infect Dis. 32 9 2001 1249 1272
88. P. Richard, R. Le Floch, C. Chamoux, M. Pannier, E. Espaze, and H. Richet Pseudomonas aeruginosa outbreak in a burn unit: role of antimicrobials in the emergence of multiply resistant strains J. Infect. Dis. 170 2 1994 377 383
89. H. Monteil, and C. Harf-Monteil J. Freney Les bacilles ̀ Gram ńgatif non fermentants autres que les Pseudomonas, in Pŕcis de bact́riologie clinique 2000 ESKA Paris 1287 1306
90. R.C. Spencer The emergence of epidemic, multiple-antibiotic-resistant Stenotrophomonas (Xanthomonas) maltophilia and Burkholderia (Pseudomonas) cepacia J. Hosp. Infect. 30 Suppl 1995 453 464
91. The French Prevalence Survey Study Group Prevalence of nosocomial infections in France: results of the nationwide survey in 1996 J. Hosp. Infect. 46 3 2000 186 193
92. J.L. Vincent, D.J. Bihari, and P.M. Suter The prevalence of nosocomial infection in intensive care units in Europe. Results of the European Prevalence of Infection in Intensive Care (EPIC) Study. EPIC International Advisory Committee JAMA 274 8 1995 639 644
93. J.L. Trouillet, J. Chastre, and A. Vuagnat Ventilator-associated pneumonia caused by potentially drug-resistant bacteria Am. J. Respir. Crit. Care Med. 157 2 1998 531 539
94. J. Chastre, and J.Y. Fagon Ventilator-associated pneumonia Am J Respir Crit Care Med 165 7 2002 867 903
95. H. Hanberger, D. Diekema, and A. Fluit Surveillance of antibiotic resistance in European ICUs J. Hosp. Infect. 48 3 2001 161 176
96. National Nosocomial Infections Surveillance (NNIS) System report, data summary from October 1986-April 1998, issued June 1998 Am. J. Infect. Control 26 5 1998 522 533
97. A.C. Gales, R.N. Jones, J. Turnidge, R. Rennie, and R. Ramphal Characterization of Pseudomonas aeruginosa isolates: occurrence rates, antimicrobial susceptibility patterns, and molecular typing in the global SENTRY Antimicrobial Surveillance Program, 1997-1999 Clin. Infect. Dis. 32 Suppl 2 2001 S146 S155
98. W.R. Jarvis, D. Olson, O. Tablan, and W.J. Martone The epidemiology of nosocomial Pseudomonas cepacia infections: endemic infections Eur. J. Epidemiol. 3 3 1987 233 236
99. A.C. Gales, R.N. Jones, K.R. Forward, J. Linares, H.S. Sader, and J. Verhoef Emerging importance of multidrug-resistant Acinetobacter species and Stenotrophomonas maltophilia as pathogens in seriously ill patients: geographic patterns, epidemiological features, and trends in the SENTRY Antimicrobial Surveillance Program (1997-1999) Clin. Infect. Dis. 32 Suppl 2 2001 S104 S113