A macromolecular prodrug of doxorubicin conjugated to a biodegradable cyclotriphosphazene bearing a tetrapeptide

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 15, 2005, Pages 3576-3579

  Jin, Kyu Kim ^a   Toti, Udaya S ^a   Song, Rita ^a,b   Youn, Soo Sohn ^a  

^a Ewha Womans University   (South Korea)

^b Institute Pasteur Korea   (South Korea)

Author keywords

Antitumor agent; Doxorubicin; Phosphazene trimer; Tetrapeptide

Indexed keywords

CYCLOTRIPHOSPHAZENE; CYCLOTRIPHOSPHAZENE DOXORUBICIN CONJUGATE; CYTOTOXIC AGENT; DOXORUBICIN; DOXORUBICIN DERIVATIVE; GLYCYLPHENYLALANYLLEUCYLGLYCINE; MACROGOL 350; MACROGOL DERIVATIVE; METHOXYPOLY(ETHYLENE GLYCOL); TETRAPEPTIDE; UNCLASSIFIED DRUG;

ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOTOXICITY; DERIVATIZATION; DRUG ACTIVITY; DRUG CONJUGATION; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME RELEASE; HUMAN; HUMAN CELL; HYDROPHILICITY; IN VITRO STUDY; LEUKEMIA CELL LINE; MACROMOLECULE; MOLECULAR WEIGHT;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BIODEGRADATION, ENVIRONMENTAL; CELL LINE, TUMOR; DOXORUBICIN; INHIBITORY CONCENTRATION 50; LEUKEMIA L1210; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR WEIGHT; NITRILES; OLIGOPEPTIDES; PHOSPHORUS COMPOUNDS; POLYETHYLENE GLYCOLS; PRODRUGS; STEREOISOMERISM;

EID: 21744449145     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.05.057     Document Type: Article

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