A cholesterol biosynthesis inhibitor from Rhizopus oryzae

Archives of Pharmacal Research

Volumn 27, Issue 6, 2004, Pages 624-627

  Hyun, Jung Kim ^a   Yim, Soon Ho ^b   Lee, Ik Soo ^a  

^a Chonnam National University   (South Korea)

^b Jeonnam Biotechnology Center for Bioindustry   (South Korea)

Author keywords

Cholesterol biosynthesis inhibitor; Methyl cholate; Rhizopus oryzae

Indexed keywords

CHOLESTEROL; CHOLIC ACID DERIVATIVE; CHOLIC ACID METHYL ESTER; HYPOCHOLESTEROLEMIC AGENT; PLANT EXTRACT;

ARTICLE; BIOSYNTHESIS; CELL CULTURE; CHEMISTRY; CYTOLOGY; HUMAN; ISOLATION AND PURIFICATION; LIVER; METABOLISM; RHIZOPUS;

ANTICHOLESTEREMIC AGENTS; CELLS, CULTURED; CHOLATES; CHOLESTEROL; HUMANS; LIVER; PLANT EXTRACTS; RHIZOPUS;

EID: 21644478185     PISSN: 02536269     EISSN: 02536269     Source Type: Journal    
DOI: 10.1007/bf02980161     Document Type: Article

References (19)

1. Abe, I., Tomesch, J. C., Wattanasin, S., and Prestwich, G. D., Inhibitors of squalene biosynthesis and metabolism. Nat. Prod. Rep., 11, 279-302 (1994).
2. Alam, N., Bae, B. H., Hong, J., Lee, C.-O., Shin, B. A., Im, K. S., and Jung, J. H., Additional bioactive Lyso-PAF congeners from the sponge Spirastrella abata. J. Nat. Prod., 64, 533-535 (2001).
3. Biller, S. A., Sofia, M. J., Abt, J. W., DeLange, B., Dickson, J. K. Jr., Forster, C., Gordon, E. M., Harrity, T., Magnin, D. R., Marretta, J., Rich, L. C., and Ciosek, C. P. Jr., Potent, rationally designed inhibitors of squalene synthase, In Nes, W. D., Parish, E. J. and Trzaskos, J. M. (Eds.). Regulation of isoprenoid metabolism. American Chemical Society, Washington DC, pp. 65-80 (1992).
4. Brown, M. S. and Goldstein, J. L., Heart attacks: gone with the century? Science, 272, 629 (1996).
5. 13C nuclear magnetic resonance data of bile acid derivatives. Spectrochim. Acta, Part A, 56, 53-77 (2000).
6. Endo, A. and Hasumi, K., HMG-CoA reductase inhibitors. Nat. Prod. Rep., 10, 541-550 (1993).
7. Gebhardt, R., Multiple inhibitory effects of garlic extracts on cholesterol biosynthesis in hepatocytes. Lipids, 28, 613-619 (1993).
8. Gebhardt, R., Inhibition of cholesterol biosynthesis in primary cultured rat hepatocytes by artichoke ( Cynara scolymus L.) extracts. J. Pharmacol. Exp. Ther., 286, 1122-1128 (1998).
9. Gerst, N., Duriatti, A., Schuber, F., Taton, M., Benveniste, P., and Rahier, A., Potent inhibition of cholesterol biosynthesis in 3T3 fibroblasts by N-[(1,5,9)-trimethyldecyl]-4α,10-dimethyl-8-aza-trans-decal-3β-ol, a new 2,3-oxidosqualene cyclase inhibitor. Biochem. Pharmacol., 37, 1955-1964 (1988).
10. Goto, J., Sano, Y., Chikai, T., and Nambara, T., Synthesis of disulfates of unconjugated and conjugated bile acids. Chem. Pharm. Bull., 35, 4562-4567 (1987).
11. Grabley, S., Granzer, E., Hütter, K., Ludwig, D., Mayer, M., Thiericke, R., Till, G., Wink, J., Philipps, S., and Zeeck, A., Secondary metabolites by chemical screening. 8. Decarestrictines, a new family of inhibitors of cholesterol biosynthesis from Penicillium. I. Strain description, fermentation, isolation and properties. J. Antibiotics, 45, 56-65 (1992).
12. Kim, H. J., Yim, S.-H., Sung, C. K., Jung, J. H., Shin, B. A., and Lee, I.-S., A new ergostane-type cholesterol biosynthesis inhibitor isolated from Hormoconis resinae. Tetrahedron Lett., 44, 7159-7162 (2003).
13. Lipid Research Clinics Program, The Lipid Research Clinics Coronary Primary Prevention Trial results. I. Reduction in incidence of coronary heart disease. J. Am. Med. Assoc., 251, 351-364 (1984a).
14. Lipid Research Clinics Program, The Lipid Research Clinics Coronary Primary Prevention Trial results. II. The relationship of reduction in incidence of coronary heart disease to cholesterol lowering. J. Am. Med. Assoc., 251, 365-374 (1984b).
15. Metherall, J. E., Waugh, K., and Li, H., Progesterone inhibits cholesterol biosynthesis in cultured cells. J. Biol. Chem., 271, 2627-2633 (1996).
16. Robbers, J. E., Speedie, M. K., and Tyler, V. E., Pharmacognosy and Pharmacobiotechnology, Williams & Wilkins, Baltimore (1996).
17. Shepherd, J., Cobbe, S. M., Ford, I., Isles, C. G., Lorimer, A. R., MacFarlane, P. W., McKillop, J. H., and Packard, C. J., Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. N. Engl. J. Med., 333, 1301-1307 (1995).
18. Shin, B. A., Kim, Y. R., Lee, I.-S., Sung, C. K., Hong, J., Sim, C. J., Im, K. S., and Jung, J. H., Lyso-PAF analogues and lysophosphatidylcholines from the marine sponge Spirastrella abata as inhibitors of cholesterol biosynthesis. J. Nat. Prod., 62, 1554-1557 (1999).
19. Trenin, A. S., Terekhova, L. P., Tolstykh, I. V., Zenkova, V. A., Fedorova, G. B., and Katrukha, G. S., Screening of microbial secondary metabolites inhibiting cholesterol biosynthesis with the use of hepatoblastoma G2 cell culture. Antibiot. Khimioter., 48, 3-8 (2003).