A new ergostane-type cholesterol biosynthesis inhibitor isolated from Hormoconis resinae

Tetrahedron Letters

Volumn 44, Issue 38, 2003, Pages 7159-7162

  Kim, Hyun Jung ^a   Yim, Soon Ho ^a   Sung, Chung Ki ^a   Jung, Jee H ^b   Shin, Boo Ahn ^a   Lee, Ik Soo ^a  

^a Chonnam National University   (South Korea)

^b Pusan National University   (South Korea)

Author keywords

3 hydroxy 1,11 dioxo ergosta 8,24(28) diene 4 carboxylic acid; Cholesterol biosynthesis inhibitor; Ergostane; Hormoconis resinae

Indexed keywords

3BETA HYDROXY 1,11 DIOXOERGOSTA 8,24(28) DIENE 4ALPHA CARBOXYLIC ACID; ALKANE DERIVATIVE; ERGOSTANE; HYPOCHOLESTEROLEMIC AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DRUG ACTIVITY; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; HORMOCONIS RESINAE; LIVER CELL; MOULD; NONHUMAN; SPECTROSCOPY; STRUCTURE ANALYSIS;

AMORPHOTHECA RESINAE; HORMOCONIS;

EID: 0041508457     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(03)01808-2     Document Type: Article

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9. 3, s, 3H), δ 3.17 (H-2β, t, J=11.5 Hz, 1H), δ 3.12 (H-4, brt, J=11.0 Hz, 1H), δ 2.93 (H-2α, dd, J=6.5, 11.5 Hz, 1H), δ 2.84 (H-12β, d, J=14.5 Hz, 1H), δ 2.72 (H-14, dd, J=7.0, 12.5 Hz, 1H), δ 2.50 (H-12α, d, J=14.5 Hz, 1H), δ 2.28 (H-7β, dd, J=4.7, 20.3 Hz, 1H), δ 2.10 (H-23b, 1H), δ 2.01 (H-16α, 1H), δ 1.88 (H-23a, 1H), δ 1.77 (H-15α, 1H), δ 1.66 (H-5, brt, J=11.0 Hz, 1H), δ 1.52 (H-19, s, 3H), δ 1.03 (H-27, d, J=6.7 Hz, 3H), δ 1.02 (H-26, d, J=6.7 Hz, 3H), δ 0.94 (H-21, d, J=6.0 Hz, 3H), δ 0. 68 (H-18, s, 3H).
10. 3, s, 3H), δ 3.16 (H-4, brt, J=11.0 Hz, 1H), δ 3.04 (H-2β, t, J=11.5 Hz, 1H), δ 2.84 (H-2α, dd, J=6.5, 11.5 Hz, 1H), δ 2.83 (H-12β, d, J=14.5 Hz, 1H), δ 2.72 (H-14, dd, J=7.0, 12.5 Hz, 1H), δ 2.50 (H-12α, d, J=14.5 Hz, 1H), δ 2.29 (H-7β, dd, J=4.7, 20.3 Hz, 1H), δ 2.10 (H-23b, 1H), δ 2.01 (H-16α, 1H), δ 1.88 (H-23a, 1H), δ 1.77 (H-15α, 1H), δ 1.68 (H-5, dt, J=2.5, 11.5 Hz, 1H), δ 1.52 (H-19, s, 3H), δ 1.03 (H-27, d, J=6.7 Hz, 3H), δ 1.02 (H-26, d, J=6.7 Hz, 3H), δ 0.94 (H-21, d, J=6.0 Hz, 3H), δ 0.68 (H-18, s, 3H).