Comparison of cytomegalovirus pp-65 antigenemia assay and plasma DNA correlation with the clinical outcome in transplant recipients

Transplant International

Volumn 18, Issue 1, 2005, Pages 43-46

  De Õna, María ^a,b   Melón, Santiago ^a   Galarraga, María C ^a   Palacio, Ana ^a   Lambert, José L ^a   Bernardo, María J ^a   Rodríguez, Manuel ^a   Gómez, Ernesto ^a  

^a HUCA   (Spain)

^b NONE   (Spain)

Author keywords

Antigenemia; Cytomegalovirus; DNAemia; Organ transplant

Indexed keywords

CYTOMEGALOVIRUS ANTIGEN PP65; DNA; CYTOMEGALOVIRUS MATRIX PROTEIN 65KDA; MATRIX PROTEIN; PHOSPHOPROTEIN; VIRUS ANTIGEN; VIRUS DNA;

ADOLESCENT; ADULT; AGED; ARTICLE; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; FEMALE; HEART GRAFT; HUMAN; KIDNEY GRAFT; LIVER GRAFT; MALE; PRIORITY JOURNAL; VIREMIA; VIRUS LOAD; BLOOD; CYTOMEGALIC INCLUSION BODY DISEASE; GENETICS; HEART TRANSPLANTATION; IMMUNOLOGY; ISOLATION AND PURIFICATION; KIDNEY TRANSPLANTATION; LIVER TRANSPLANTATION; MIDDLE AGED; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGED; ANTIGENS, VIRAL; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; DNA, VIRAL; HEART TRANSPLANTATION; HUMANS; KIDNEY TRANSPLANTATION; LIVER TRANSPLANTATION; MIDDLE AGED; PHOSPHOPROTEINS; TREATMENT OUTCOME; VIRAL LOAD; VIRAL MATRIX PROTEINS;

EID: 21644452386     PISSN: 09340874     EISSN: 14322277     Source Type: Journal    
DOI: 10.1111/j.1432-2277.2004.00033.x     Document Type: Article

References (22)

1. Conti DJ, Freed BM, Singh TP, Gallichio M, Gruber SA, Lempert N. Preemptive ganciclovir therapy in cytomegalo-virus-seropositive renal transplant recipients. Arch Surg 1995; 130: 1217.
2. Couchoud C, Cucherat M, Haugh M, Pouteil-Noble C. Cytomegalovirus prophylaxis with antiviral agents in solid organ transplantation: a meta-analysis. Transplantation 1998; 65: 641.
3. Merigan TC, Renlund DG, Keay S, et al. A controlled trial of ganciclovir to prevent cytomegalovirus disease after heart transplantation. N Engl J Med 1992; 326: 1182.
4. Gomez E, de Ona M, Aguado S, et al. Cytomegalovirus preemptive therapy with ganciclovir in renal transplant patients treated with OKT3. Nephron 1996; 74: 367.
5. Singh N. Preemptive therapy versus universal prophylaxis with ganciclovir for Cytomegalovirus in solid organ transplant recipients. Clin Infect Dis 2001; 32: 742.
6. Isada CM, Yen-Lieberman B, Kohn D, et al. Emergence of clinically significant ganciclovir (GCV)-resistant strains of CMV in solid organ transplant recipients. Transplantation 2000; 69: S181.
7. de Ona Navarro M, Melon S, Mendez S, et al. Assay of cytomegalovirus susceptibility to ganciclovir in renal and heart transplant recipients. Transplant Int 2002; 15: 570.
8. Limaye AP, Corey L, Koelle DM, Davis CL, Boeckh M. Emergence of ganciclovir-resistant cytomegalovirus disease among solid-organ transplants. Lancet 2000; 536: 645.
9. The TH, van der Bij W, van den Berg AP et al. Cytomegalovirus antigenemia. Rev Infect Dis 1990; 7: S734.
10. Hiyoshi M, Tagawa S, Takubo T, et al. Evaluation of the AMPLICOR CMV test for direct detection of cytomegalovirus in plasma specimens. J Clin Microbiol 1997; 35: 2692.
11. Sia IG, Wilson JA, Espy MJ, Paya CV, Smith TF. Evaluation of the COBAS AMPLICOR CMV MONITOR test for detection of viral DNA in specimens taken from patients after liver transplantation. J Clin Microbiol 2000; 38: 600.
12. Gomez E, Aguado S, Melon S, et al. A prospective study of the usefulness of rapid diagnostic tests in monitoring cytomegalovirus infection in renal transplants. Transplant Proc 1992; 24: 2631.
13. Baldanti F, Zavattani M, Sarasini A, Gatti M, Chezzi L, Gerna G. Comparative quantification of human cytomegalovirus DNA in blood of immunocompromised patients by PCR and Murex Hybrid Capture System. Clin Diagn Virol 1997; 8: 159.
14. Imbert-Marcille BM, Cantarovich D, Ferre-Aubineau V, Richet B, Soulillou JP, Billaudel S. Usefulness of DNA viral load quantification for cytomegalovirus disease monitoring in renal and pancreas/renal transplant recipients. Transplantation 1997; 63: 1476.
15. Macartney M, Gane EJ, Portmann B, Williams R. Comparison of a new quantitative cytomegalovirus DNA assay with other detection methods. Transplantation 1997; 63: 1803.
16. Veal N, Payan C, Fray D, et al. Novel DNA assay for cytomegalovirus detection: comparison with conventional culture and pp65 antigenemia assay. J Clin Microbiol 1996; 34: 3097.
17. Emery VC, Sabin CA, Cope AV, Gor D, Hassan-Walker AF, Griffiths PD. Application of viral-load kinetics to identify patients who develop cytomegalovirus disease after transplantation. Lancet 2000; 355: 2032.
18. Mendez J, Espy M, Smith TF, Wilson J, Wiesner R, Paya CV. Clinical significance of viral load in the diagnosis of cytomegalovirus disease after liver transplantation. Transplantation 1998; 65: 1477.
19. Sia IG, Wilson JA, Groettum CM, Espy MJ, Smith TF, Paya CV. Cytomegalovirus (CMV) DNA load predicts relapsing CMV infection after solid organ transplantation. J Infect Dis 2000; 181: 717.
20. Dodt KK, Jacobsen PH, Hofmann B, et al. Development of cytomegalovirus (CMV) disease may be predicted in HIV-infected patients by CMV polymerase chain reaction and the antigenemia test. AIDS 1997; 11: F21.
21. Francisci D, Tosti A, Baldelli F, Stagni G, Pauluzzi S. The pp65 antigenemia test as a predictor of cytomegalovirus-induced end-organ disease in patients with AIDS. AIDS 1997; 11: 1341.
22. Gerna G, Zavattoni M, Percivalle E, Grossi P, Torsellini M, Revello MG. Rising levels of human cytomegalovirus (HCMV) antigenemia during initial antiviral treatment of solid-organ transplant recipients with primary HCMV infection. J Clin Microbiol 1998; 36: 1113.