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Volumn 12, Issue 1, 2004, Pages 25-31

Disruption of p53-p21/WAF1 cell cycle pathway contributes to progression and worse clinical outcome of hepatocellular carcinoma

Author keywords

Hepatocellular carcinoma; p21 WAF1; p53; Progression; Proliferating cell nuclear antigen

Indexed keywords

CDKN1A PROTEIN, HUMAN; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLINE;

EID: 21644447666     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.12.1.25     Document Type: Article
Times cited : (14)

References (29)
  • 1
    • 0026702212 scopus 로고
    • Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element
    • Zambetti GP, Bargonetti J, Walker K, Prives C and Levine AJ: Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element. Genes Dev 6: 1143-1152, 1992.
    • (1992) Genes Dev , vol.6 , pp. 1143-1152
    • Zambetti, G.P.1    Bargonetti, J.2    Walker, K.3    Prives, C.4    Levine, A.J.5
  • 3
    • 0027496935 scopus 로고
    • The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin- dependent kinases
    • DOI 10.1016/0092-8674(93)90499-G
    • Harper JW, Adami GR, Wei N, Keyomarsi K and Elledge SJ: The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75: 805-816, 1993. (Pubitemid 23346377)
    • (1993) Cell , vol.75 , Issue.4 , pp. 805-816
    • Harper, J.W.1    Adami, G.R.2    Wei, N.3    Keyomarsi, K.4    Elledge, S.J.5
  • 4
    • 0027717617 scopus 로고
    • p21 is a universal inhibitor of cyclin kinases
    • DOI 10.1038/366701a0
    • Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R and Beach D: p21 is a universal inhibitor of cyclin kinases. Nature 366: 701-704, 1993. (Pubitemid 24036020)
    • (1993) Nature , vol.366 , Issue.6456 , pp. 701-704
    • Xiong, Y.1    Hannon, G.J.2    Zhang, H.3    Casso, D.4    Kobayashi, R.5    Beach, D.6
  • 5
    • 0028985518 scopus 로고
    • p53-independent induction of WAF1/CIP1 in human leukemia cells is correlated with growth arrest accompanying monocyte/macrophage differentiation
    • Zhang W, Grasso L, McClain CD, et al: p53-independent induction of WAF1/CIP1 in human leukemia cells is correlated with growth arrest accompanying monocyte/macrophage differentiation. Cancer Res 55: 668-674, 1995.
    • (1995) Cancer Res , vol.55 , pp. 668-674
    • Zhang, W.1    Grasso, L.2    McClain, C.D.3
  • 7
    • 0028123801 scopus 로고
    • p53 gene mutation spectrum in hepatocellular carcinomas in Hong Kong Chinese
    • Ng IOL, Chung LP, Tsang SW, Lam CL, Lai EC, Fan ST and Ng M: p53 gene mutation spectrum in hepatocellular carcinomas in Hong Kong Chinese. Oncogene 9: 985-990, 1994. (Pubitemid 24065942)
    • (1994) Oncogene , vol.9 , Issue.3 , pp. 985-990
    • Ng, I.O.L.1    Chung, L.P.2    Tsang, S.W.Y.3    Lam, C.L.4    Lai, E.C.S.5    Fan, S.T.6    Ng, M.7
  • 8
    • 0034241501 scopus 로고    scopus 로고
    • Relationship between p53 overexpression and the proliferative activity in hepatocellular carcinoma
    • Itoh T, Shiro T, Seki T, Nakagawa T, Wakabayashi M, Inoue K and Okamura A: Relationship between p53 overexpression and the proliferative activity in hepatocellular carcinoma. Int J Mol Med 6: 137-142, 2000.
    • (2000) Int J Mol Med , vol.6 , pp. 137-142
    • Itoh, T.1    Shiro, T.2    Seki, T.3    Nakagawa, T.4    Wakabayashi, M.5    Inoue, K.6    Okamura, A.7
  • 10
    • 0034077411 scopus 로고    scopus 로고
    • Reduced p21(WAF1/CIP1) protein expression is predominantly related to altered p53 in hepatocellular carcinomas
    • Shi YZ, Hui AM, Takayama T, Li X, Cui X and Makuuchi M: Reduced p21(WAF1/CIP1) protein expression is predominantly related to altered p53 in hepatocellular carcinomas. Br J Cancer 83: 50-55, 2000. (Pubitemid 30352716)
    • (2000) British Journal of Cancer , vol.83 , Issue.1 , pp. 50-55
    • Shi, Y.-Z.1    Hui, A.-M.2    Takayama, T.3    Li, X.4    Cui, X.5    Makuuchi, M.6
  • 11
    • 0342313805 scopus 로고    scopus 로고
    • Overexpression of p53 protein is not directly related to hepatitis B x protein expression and is associated with neoplastic progression in hepatocellular carcinomas rather than hepatic preneoplasia
    • DOI 10.1016/S1383-5742(00)00026-0, PII S1383574200000260
    • Su Q, Schroder CH, Otto G and Bannasch P: Overexpression of p53 protein is not directly related to hepatitis B x protein expression and is associated with neoplastic progression in hepatocellular carcinomas rather than hepatic preneoplasia. Mutat Res 462: 365-380, 2000. (Pubitemid 30190242)
    • (2000) Mutation Research - Reviews in Mutation Research , vol.462 , Issue.2-3 , pp. 365-380
    • Su, Q.1    Schroder, C.H.2    Otto, G.3    Bannasch, P.4
  • 12
    • 78651053628 scopus 로고
    • Primary carcinoma of liver: A study of 100 cases among 48,900 necropsies
    • Edmondson HA and Steiner PE: Primary carcinoma of liver: a study of 100 cases among 48,900 necropsies. Cancer 7: 462-503, 1954.
    • (1954) Cancer , vol.7 , pp. 462-503
    • Edmondson, H.A.1    Steiner, P.E.2
  • 14
    • 0034282518 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer
    • Birner P, Schindl M, Obermair A, Plank C, Breitenecker G and Oberhuber G: Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer. Cancer Res 60: 4693-4696, 2000.
    • (2000) Cancer Res , vol.60 , pp. 4693-4696
    • Birner, P.1    Schindl, M.2    Obermair, A.3    Plank, C.4    Breitenecker, G.5    Oberhuber, G.6
  • 15
    • 0035900769 scopus 로고    scopus 로고
    • Involvement of the interaction between p21 and proliferating cell nuclear antigen for the maintenance of G2/M arrest after DNA damage
    • Ando T, Kawabe T, Ohara H, Ducommun B, Itoh M and Okamoto T: Involvement of the interaction between p21 and proliferating cell nuclear antigen for the maintenance of G2/M arrest after DNA damage. J Biol Chem 276: 42971-42977, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 42971-42977
    • Ando, T.1    Kawabe, T.2    Ohara, H.3    Ducommun, B.4    Itoh, M.5    Okamoto, T.6
  • 16
    • 0028294605 scopus 로고
    • WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis
    • El-Deiry WS, Harper JW, O'Connor PM, et al. WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res 54: 1169-1174, 1994.
    • (1994) Cancer Res , vol.54 , pp. 1169-1174
    • El-Deiry, W.S.1    Harper, J.W.2    O'Connor, P.M.3
  • 19
    • 0029670143 scopus 로고    scopus 로고
    • p21 RNA and protein expression in non-small cell lung carcinomas: Evidence of p53-independent expression and association with tumoral differentiation
    • Marchetti A, Doglioni C, Barbareschi M, et al: p21 RNA and protein expression in non-small cell lung carcinomas: evidence of p53-independent expression and association with tumoral differentiation. Oncogene 12: 1319-1324, 1996.
    • (1996) Oncogene , vol.12 , pp. 1319-1324
    • Marchetti, A.1    Doglioni, C.2    Barbareschi, M.3
  • 20
    • 0028981086 scopus 로고
    • Topological control of p21WAF1/CIP1 expression in normal and neoplastic tissues
    • El-Deiry WS, Tokino T, Waldman T, et al: Topological control of p21WAF1/CIP1 expression in normal and neoplastic tissues. Cancer Res 55: 2910-2919, 1995.
    • (1995) Cancer Res , vol.55 , pp. 2910-2919
    • El-Deiry, W.S.1    Tokino, T.2    Waldman, T.3
  • 21
    • 0029815820 scopus 로고    scopus 로고
    • Differentiation-associated overexpression of the cyclin-dependent kinase inhibitor p21(waf-1) in human cutaneous squamous cell carcinoma
    • Tron VA, Tang L, Yong WP and Trotter MJ: Differentiation-associated overexpression of the cyclin-dependent kinase inhibitor p21waf-1 in human cutaneous squamous cell carcinoma. Am J Pathol 149: 1139-1146, 1996. (Pubitemid 26337233)
    • (1996) American Journal of Pathology , vol.149 , Issue.4 , pp. 1139-1146
    • Tron, V.A.1    Tang, L.2    Yong, W.P.3    Trotter, M.J.4
  • 22
    • 0000389767 scopus 로고    scopus 로고
    • p21/WAF1, p53 and PCNA expression and p53 mutation status in hepatocellular carcinoma
    • DOI 10.1002/(SICI)1097-0215(19980821)79:4<424::AID
    • Qin LF, Ng IOL, Fan ST and Ng M: p21/WAF1, p53 and PCNA expression and p53 mutation status in hepatocellular carcinoma. Int J Cancer 79: 424-428, 1998. (Pubitemid 28359743)
    • (1998) International Journal of Cancer , vol.79 , Issue.4 , pp. 424-428
    • Qin, L.F.1    Ng, I.O.L.2    Fan, S.T.3    Ng, M.4
  • 24
    • 0031861417 scopus 로고    scopus 로고
    • Cyclin-dependent kinase inhibitor p21 modulates the DNA primer-template recognition complex
    • Waga S and Stillman B: Cyclin-dependent kinase inhibitor p21 modulates the DNA primer-template recognition complex. Mol Cell Biol 18: 4177-4187, 1998. (Pubitemid 28287941)
    • (1998) Molecular and Cellular Biology , vol.18 , Issue.7 , pp. 4177-4187
    • Waga, S.1    Stillman, B.2
  • 25
    • 0030770835 scopus 로고    scopus 로고
    • Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21(WAF1)
    • DOI 10.1126/science.277.5334.1996
    • Chuang LS, Ian HI, Koh TW, Ng HH, Xu G and Li BF: Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21WAF1. Science 277: 1996-2000, 1997. (Pubitemid 27449142)
    • (1997) Science , vol.277 , Issue.5334 , pp. 1996-2000
    • Chuang, L.S.-H.1    Ian, H.-I.2    Koh, T.-W.3    Ng, H.-H.4    Xu, G.5    Li, B.F.L.6
  • 26
    • 0028271583 scopus 로고
    • Prognostic significance of proliferating cell nuclear antigen expression in hepatocellular carcinoma
    • Ng IOL, Lai EC, Fan ST, Ng M, Chan AS and So MK: Prognostic significance of proliferating cell nuclear antigen expression in hepatocellular carcinoma. Cancer 73: 2268-2274, 1994. (Pubitemid 24129107)
    • (1994) Cancer , vol.73 , Issue.9 , pp. 2268-2274
    • Ng, I.O.L.1    Lai, E.C.S.2    Fan, S.T.3    Ng, M.4    Chan, A.S.Y.5    So, M.K.P.6
  • 27
    • 0035935259 scopus 로고    scopus 로고
    • WAF1/CIP1 exerts cell growth inhibition and enhances sensitivity to cisplatin in hepatoma cells
    • DOI 10.1016/S0304-3835(01)00701-7, PII S0304383501007017
    • Qin LF and Ng IOL: Exogenous expression of p21(WAF1/CIP1) exerts cell growth inhibition and enhances sensitivity to cisplatin in hepatoma cells. Cancer Lett 172: 7-15, 2001. (Pubitemid 32823467)
    • (2001) Cancer Letters , vol.172 , Issue.1 , pp. 7-15
    • Qin, L.F.1    Ng, I.O.L.2
  • 28
    • 0036244231 scopus 로고    scopus 로고
    • WAF1/CIP1 levels leads to growth suppression of prostate cancer cell lines
    • Sugibayashi R, Kiguchi Y, Shimizu T, Suzuki T, Hamada H and Takeda K: Up-regulation of p21(WAF1/CIP1) levels leads to growth suppression of prostate cancer cell lines. Anticancer Res 22 (2A): 713-719, 2002. (Pubitemid 34475219)
    • (2002) Anticancer Research , vol.22 , Issue.2 A , pp. 713-719
    • Sugibayashi, R.1    Kiguchi, Y.2    Shimizu, T.3    Suzuki, T.4    Hamada, H.5    Takeda, K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.