Assessment of the biological malignancy of hepatocellular carcinoma: Relationship to clinicopathological factors and prognosis

Clinical Cancer Research

Volumn 4, Issue 6, 1998, Pages 1475-1482

  Mise, Kotaro ^a   Tashiro, Seiki ^a   Yogita, Shiro ^a   Wada, Daisuke ^a   Harada, Masamitsu ^a   Fukuda, You ^a   Miyake, Hidenori ^a   Isikawa, Masashi ^a   Izumi, Keiske ^a   Sano, Nobuya ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ANEUPLOIDY; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CHROMOSOME NOR; DNA CONTENT; FEMALE; HISTOPATHOLOGY; HUMAN; LABELING INDEX; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; PLOIDY; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; RISK ASSESSMENT; RISK FACTOR; TUMOR VOLUME;

ADULT; AGE FACTORS; AGED; ANEUPLOIDY; BIOPSY; CARCINOMA, HEPATOCELLULAR; CELL DIFFERENTIATION; DIPLOIDY; DNA, NEOPLASM; FEMALE; FOLLOW-UP STUDIES; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; MITOTIC INDEX; MULTIVARIATE ANALYSIS; NUCLEOLUS ORGANIZER REGION; PREDICTIVE VALUE OF TESTS; PROGNOSIS; PROLIFERATING CELL NUCLEAR ANTIGEN; REGRESSION ANALYSIS; RISK FACTORS; SURVIVAL RATE; TIME FACTORS; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53;

EID: 17544397131     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Liver Cancer Study Group of Japan. The General Rules for the Clinical and Pathological Study of Primary Liver Cancer, Ed. 3. 1992.
2. Schutte, B., Reynders, M. M. J., and Bosman, F. T. Flow cytometric determination of DNA ploidy level in nuclei isolated from paraffin-embedded tissue. Cytometry, 6: 26-30, 1985.
3. Vindel, L. L., Christensen, I. J., and Nissen, N. I. A detergent-trypsin method for the preparation of nuclei for flow cytometric DNA analysis. Cytometry, 3: 323-327, 1983.
4. Crocker, J., and Nar, P. Nucleolar organizer regions in lymphomas. J. Pathol., 151: 111-118, 1987.
5. Ishizu, H. Flow cytometric analysis of the nuclear DNA content of hepatocellular carcinoma. Jpn. J. Surg., 19: 662-673, 1989.
6. Fujimoto, J., Okamoto, E., Yamanaka, N., Toyosaka, A., and Mitsunobu, M. Flow cytometric DNA analysis of hepatocellular carcinoma. Cancer (Phila.), 67: 939-944, 1991.
7. McEntee, G. P., Batts, K. A., Katzmann, J. A., Ilstrup, D. M., and Nagorney, D. M. Relationship of nuclear DNA content to clinical and pathologic findings in patients with primary hepatic malignancy. Surgery (St. Louis), 111: 376-379, 1992.
8. Ezaki, T., Kanematsu, T., Okamura, T., Sonoda, T., and Sugimachi, K. DNA analysis of hepatocellular carcinoma and clinicopathologic implications. Cancer (Phila.), 61: 106-109, 1988.
9. Okada, S., Ishii, H., Nose, H., Okusaka, T., Kyogoku, A., Yoshimori, M., Sakamoto, M., and Hirohashi, S. Intratumoral DNA heterogeneity of small hepatocellular carcinoma. Cancer (Phila.), 75: 444-450, 1995.
10. Isobe, M., Emanuel, B. S., Gival, D., Oren, M., and Croce, C. M. Localization of gene for human p53 tumor antigen to band 17p13. Nature (Lond.), 320: 84-85, 1986.
11. Lane, D. P. Cancer p53, guardian of the genome. Nature (Lond.), 358: 15-16, 1992.
12. Greenblatt, M. S., Bennett, W. P., Hollstein, M., and Harris, C. C. Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res., 54: 4855-4878, 1994.
13. Oda, T., Tsuda, H., Scarpa, A., Sakamoto, M., and Hirohashi, S. Mutation pattern of the p53 gene as a diagnostic marker for multiple hepatocellular carcinoma. Cancer Res., 52: 3674-3678, 1992.
14. Nose, H., Imazeki, F., Ohto, M., and Omata, M. p53 gene mutations, and 17p allelic deletions in hepatocellular carcinoma from Japan. Cancer (Phila.), 72: 355-360, 1993.
15. Livni, N., Eid, A., Ilan, Y., Ilan, Y., Rivkind, A., Rosenmann, E., Blendis, L. M., Shouval, D., and Galun, E. p53 expression in patients with cirrhosis with and without hepatocellular carcinoma. Cancer (Phila.), 75: 2420-2426, 1995.
16. Teramoto, T., Satonaka, K., Kitazawa, S., Fujimori, T., Hayashi, K., and Maeda, S. p53 gene abnormalities are closely related to hepatoviral infections and occur at a late stage of hepatocarcinogenesis. Cancer Res., 54: 231-235, 1994.
17. Oda, T., Tsuda, H., Scarpa, A., Sakamoto, M., and Hirohashi, S. p53 gene mutation spectrum in hepatocellular carcinoma. Cancer Res., 52: 6358-6364, 1992.
18. Adachi, E., Hashimoto, H., and Tsuneyoshi, M. Proliferating cell nuclear antigen in hepatocellular carcinoma and small cell liver dysplasia. Cancer (Phila.), 72: 2902-2909, 1993.
19. Kitamoto, M., Nakanishi, T., Kira, S., Kawaguchi, M., Nakashio, R., Suemori, S., Kajiyama, G., Asahara, T., and Dohi, K. The assessment of proliferating cell nuclear antigen immunohistochemical staining in small hepatocellular carcinoma and its relationship to histologic characteristics and prognosis. Cancer (Phila.), 72: 1859-1865, 1993.
20. Howell, W. M., and Black, D. A. Controlled silver-staining of nucleolus organizer regions with a protective colloidal developer: a 1 step method. Experientia (Basel), 36: 1014-1015, 1980.