Fluorine-containing pyrido[1,2-a]quinazolin-6-ones

Russian Chemical Bulletin

Volumn 53, Issue 10, 2004, Pages 2314-2318

  Nosova, E V ^a   Lipunova, G N ^a   Kodess, M I ^b   Vasil'eva, P V ^a   Charushin, V N ^b  

^a URAL FEDERAL UNIVERSITY   (Russian Federation)

^b INSTITUTE OF ORGANIC SYNTHESIS   (Russian Federation)

Author keywords

2,3,4,5 tetrafluorobenzoyl chloride; 2 aminopyridine; Aminodefluorination; Aroylation; Pyrido 1,2 a quinazolin 6 ones

Indexed keywords

5 NITRO 2 (2,3,4,5 TETRAFLUOROBENZOYL)AMINOPYRIDINE; 6 METHYL 2 (2,3,4,5 TETRAFLUOROBENZOYL)AMINOPYRIDINE; 8,10 DIFLUORO 2 METHYL 9 (MORPHOLIN 4 YL) 6H PYRIDO[1,2 A]QUINAZOLIN 6 ONE; 8,10 DIFLUORO 2 METHYL 9 (PYRROLIDIN 1 YL) 6H PYRIDO[1,2 A]QUINAZOLIN 6 ONE; 8,10 DIFLUORO 9 (MORPHOLIN 4 YL) 6H PYRIDO[1,2 A]QUINAZOLIN 6 ONE; 8,10 DIFLUORO 9 (PYRROLIDIN 1 YL) 6H PYRIDO[1,2 A]QUINAZOLIN 6 ONE; 8,9,10 TRIFLUORO 2 METHYL 6H PYRIDO[1,2 A]QUINAZOLIN 6 ONE; 8,9,10 TRIFLUORO 6H PYRIDO[1,2 A]QUINAZOLIN 6 ONE; FLUORINE; PYRIDINE DERIVATIVE; PYRIDINIUM DERIVATIVE; QUINAZOLINE DERIVATIVE; TOLUENE; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL REACTION KINETICS; CHEMICAL STRUCTURE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

EID: 21644433043     PISSN: 10665285     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11172-005-0119-5     Document Type: Article

References (21)

1. J. Bartroli, E. Turmo, M. Alguero, E. Boncompte, M. L. Vericat, L. Conte, J. Ramis, M. Merlos, J. G. Rafanell, and J. Forn, J. Med. Chem., 1998, 41, 1869.
2. J. F. Wolfe, T. L. Rathman, M. C. Sleevi, J. A. Campbell, and T. D. Greenwood, J. Med. Chem., 1990, 33, 161.
3. M. J. Yu, J. R. McCowan, N. R. Mason, J. B. Deeter, and L. G. Mendelsohn, J. Med. Chem., 1992, 35, 2534.
4. J. K. Padia, M. Field, J. Hinton, K. Meecham, J. Pablo, R. Pinnock, B. D. Roth, L. Singh, N. S. Chauhan, B. K. Trivedi, and L. Webdale, J. Med. Chem., 1998, 41, 1042.
5. Organofluorine Compounds in Medicinal Chemistry and Biomedical Applications, Eds R. Filler, Y. Kobayashi, and L. M. Yagupolskii, Elsevier, Amsterdam, 1993, 480 p.
6. G. A. Mokrushina, E. V. Nosova, G. N. Lipunova, and V. N. Charushin, Zh. Org. Khim., 1999, 35, 1447
7. [Russ. J. Org. Chem., 1999, 35 (Engl. Transl.)].
8. G. A. Mokrushina, V. N. Charushin, and O. N. Chupakhin, Khim.-Farm. Zh., 1995, 29, 5
9. [Pharm. Chem. J., 1995, 29, No. 9 (Engl. Transl.)].
10. M. J. Deetz, J. P. Malerich, A. M. Beatty, and B. D. Smith, Tetrahedron Lett., 2001, 42, 1851.
11. G. N. Lipunova, G. A. Mokrushina, E. V. Granovskaya, O. M. Chasovskikh, and V. N. Charushin, Mendeleev Commun., 1996, 15.
12. V. N. Charushin, E. V. Nosova, G. N. Lipunova, and M. I. Kodess, J. Fluorine Chem., 2001, 110, 25.
13. V. N. Charushin, G. N. Lipunova, E. V. Nosova, L. P. Sidorova, and O. M. Chasovskikh, Mendeleev Commun., 1998, 131.
14. G. N. Lipunova, E. V. Nosova, N. N. Mochul'skaya, A. A. Andreiko, O. M. Chasovskikh, and V. N. Charushin, Izv. Akad. Nauk, Ser. Khim., 2002, 613
15. [Russ. Chem. Bull., Int. Ed., 2002, 51, 663].
16. G. N. Lipunova, E. V. Nosova, P. V. Vasil'eva, and V. N. Charushin, Izv. Akad. Nauk, Ser. Khim., 2003, 436
17. [Russ. Chem. Bull., Int. Ed., 2003, 52, 457].
18. G. N. Lipunova, E. V. Nosova, G. A. Mokrushina, E. G. Ogloblina, G. G. Aleksandrov, and V. N. Charushin, Zh. Org. Khim., 2003, 39, 270
19. [Russ. J. Org. Chem., 2003, 39, No. 2 (Engl. Transl.)].
20. W. R. Dolbier, C. Burkholder, K. A. Abboud, and D. Loehle, J. Org. Chem., 1994, 59, 7688.
21. L. W. Deady, M. F. Mackay, and D. M. Werden, J. Heterocycl. Chem., 1989, 26, 161.