Characteristic intestinal microflora of specific pathogen-free mice bred in two different colonies and their influence of postnatal murine immunocyte profiles

Experimental Animals

Volumn 54, Issue 2, 2005, Pages 143-148

  Nagurai, Taizo ^a,b   Hachimura, Satoshi ^a   Kaminogawa, Shuichi ^a   Aritsuka, Tsutomu ^b   Itoh, Kikuji ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b Nippon Beet Sugar Mfg Co Ltd   (Japan)

Author keywords

Immunity; Intestinal microflora; Intraepithelial lymphocytes; SPF mice

Indexed keywords

ACETIC ACID; BUTYRIC ACID; CARBOXYLIC ACID; CD8 ANTIGEN; CD8ALPHA ANTIGEN; CD8BETA ANTIGEN; FORMIC ACID; LACTIC ACID; PROPIONIC ACID; RAFFINOSE; SUCCINIC ACID; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; UNCLASSIFIED DRUG; ACETIC ACID DERIVATIVE; OLIGOSACCHARIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL COUNT; BACTEROIDACEAE; BIFIDOBACTERIUM; BREAST FEEDING; CECUM; CLOSTRIDIUM; CONTROLLED STUDY; ENTEROBACTERIACEAE; EUBACTERIACEAE; FEMALE; FLOW CYTOMETRY; FUSOBACTERIUM; HYSTERECTOMY; INTESTINE; INTESTINE FLORA; LACTATION; LACTOBACILLUS; LYMPHOCYTE SUBPOPULATION; MOUSE; NONHUMAN; PEPTOCOCCACEAE; PERINATAL PERIOD; SPLEEN CELL; STRAIN DIFFERENCE; STREPTOCOCCACEAE; ANIMAL; DIET; GERMFREE ANIMAL; IMMUNOLOGY; LYMPH NODE; METABOLISM; MICROBIOLOGY; MOUSE STRAIN; NEWBORN; PREGNANCY; SPLEEN;

MURINAE;

ACETIC ACIDS; ANIMALS; ANIMALS, NEWBORN; CECUM; DIET; FEMALE; HYSTERECTOMY; LYMPH NODES; LYMPHOCYTE SUBSETS; MICE; MICE, INBRED STRAINS; OLIGOSACCHARIDES; PREGNANCY; SPECIFIC PATHOGEN-FREE ORGANISMS; SPLEEN;

EID: 21444452036     PISSN: 13411357     EISSN: None     Source Type: Journal    
DOI: 10.1538/expanim.54.143     Document Type: Article

References (15)

1. American Institute of Nutrition. 1979. Report of the American Institute of Nutrition ad hoc Committee on Standards for Nutritional Studies. J. Nutr. 107: 1340-1348.
2. Bandeira, A., Mota-Santos, T., T., Itohara, S., Degermann, S., Heusser, C., Tonegawa, S., and Coutinho, A. 1990 Localization of γ/δ T cells to the intestinal epithelium is independent of normal microbial colonization.J. Exp. Med. 172: 239-244.
3. Benno, Y., Endo, K., Shiragami, N., Sayama, K., and Mitsuoka, T. 1987. Effects of raffinose intake on human fecal microflora. Bifidobacteria Microflora 6: 59-63.
4. Berg, R.D. 1983. Host immune response to antigens of the indigenous intestinal flora. pp. 101-126. In: Human Intestinal Microflora in Health and Disease (Hentges, D.J. eds.), Academic Press, New York.
5. Davis, C.P., McAllister, J.S., and Savage, D.C. 1973. Microbial colonization of the intestinal epithelium in suckling mice. Infect. Immun. 7: 666-672.
6. 2-microglobulin- and/or TAP1-deficient mice. J. Immunol. 156: 2710-2715.
7. Itoh, K., Oowada, T., and Mitsouka, T. 1985. Characteristic faecal flora of NC mice. Lab. Anim. 19: 7-15.
8. Maejima, K., Maejima, F., Tajima, Y., and Okugi, M. 1967. Viable count of various bacteria in the digestive tract of mice. III. Changes of viable count of fecal bacteria with age. Bull. Exp. Anim. 16: 20-25.
9. Mitsouka, T., Sega, T., and Yamamoto, S. 1965. Eine verbesserte methodik der qualitativen und quantitativen analyse der darmflora von menschen und tieren. Zbl. Bakt. Hyg., I. Abt. Orig. 195: 455-469 (in German).
10. Rothkotter, H.J. and Pabst, R. 1989. Lymphocyte subsets in jejunal and ileal Peyer's patches of normal and gnotobiotic minipigs. Immunology 67: 103-108.
11. Toivanen, P., Vaahtovuo, J., and Eerola, E. 2001. Influence of major histocompatibility complex on bacterial composition of fecal flora. Infect. Immun. 69: 2372-2377.
12. Umesaki, Y., Okada, Y., Matsumoto, S., Imaoka, A., and Setoyama, H. 1995. Segmented filamentous bacteria are indigenous intestinal bacteria that activate intraepithelial lymphocytes and induce MHC class II molecules and fucosyl asialo GM1 glycolipids on the small intestinal epithelial cells in the ex-germ-free mouse. Microbiol. Immunol. 39: 555-562.
13. Umesaki, Y., Setoyama, H., Matsumoto, S., Imaoka, A., and Itoh, K. 1999. Differential roles of segmented filamentous bacteria and clostridia in development of the intestinal immune system. Infect. Immun. 67: 3504-3511.
14. Umesaki, Y., Setoyama, H., Matsumoto, S., and Okada, Y. 1993. Expansion of αβT-cell receptor-bearing intestinal intraepithelial lymphocytes after microbial colonization in germ-free mice and its independence from thymus. Immunology. 79: 32-37.
15. Yazawa, K. and Tamura, Z. 1982. Search for sugar sources for selective increase of bifidobacteria. Bifidobacteria Microflora 1: 39-44.