Poly(D,L-lactide) coating is capable of enhancing osseous integration of Schanz screws in the absence of infection

Journal of Biomedical Materials Research - Part B Applied Biomaterials

Volumn 74, Issue 1, 2005, Pages 608-616

  Partale, K ^a   Klein, P ^a   Schell, H ^a   Schmidmaier, G ^a   Wildemann, B ^a   Bail, H ^a   Schiller, R ^a   Bragulla, H ^b   Duda, G N ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Biodegradable polylactide coatings; External fixator; Osteoclast; Pin track infections; Remodeling

Indexed keywords

BACTERIA; BIOMECHANICS; BIOPOLYMERS; BONE; FRACTURE FIXATION; IMPLANTS (SURGICAL); INTEGRATION;

BIODEGRADABLE COATINGS; IMPLANT-BONE INTERFACES; MONO-LATERAL EXTERNAL FIXATORS; SCHANZ' SCREWS;

PLASTIC COATINGS;

AGAR; POLYLACTIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL COLONIZATION; BIODEGRADATION; BIOMECHANICS; BONE REMODELING; BONE SCREW; CONTROLLED STUDY; DISEASE SEVERITY; EXTERNAL FIXATOR; FEMALE; FRACTURE EXTERNAL FIXATION; HISTOCHEMISTRY; MATERIAL COATING; MICROBIOLOGICAL EXAMINATION; MORPHOMETRICS; NONHUMAN; OSSIFICATION; OSTEOCLAST; OSTEOTOMY; PROSTHESIS INFECTION; PROSTHESIS LOOSENING; SHEEP; STAPHYLOCOCCUS AUREUS;

AGAR; ANIMALS; BONE SCREWS; COATED MATERIALS, BIOCOMPATIBLE; EXTERNAL FIXATORS; FRACTURE FIXATION; INFLAMMATION; METHYLMETHACRYLATE; OSSEOINTEGRATION; OSTEOCLASTS; OSTEOTOMY; POLYESTERS; SHEEP; STAPHYLOCOCCUS AUREUS; TIME FACTORS;

EID: 21444450194     PISSN: 00219304     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbm.b.30254     Document Type: Article

References (40)

1. Churches AE, Tanner KE, Harris JD. The Oxford External Fixator: Fixator stiffness and the effects of bone pin loosening. Eng Med 1985;14:3-11, 29.
2. Green SA, Ripley MJ. Chronic osteomyelitis in pin tracks. J Bone Joint Surg Am 1984;66:1092-1098.
3. Collinge CA, Goll G, Seligson D, Easley KJ. Pin tract infections: Silver vs uncoated pins. Orthopedics 1994;17:445-448.
4. Gordon JE, Kelly-Hahn J, Carpenter CJ, Schoenecker PL. Pin site care during external fixation in children: Results of a nihilistic approach. J Pediatr Orthop 2000;20:163-165.
5. Mahan J, Seligson D, Henry SL, Hynes P, Dobbins J. Factors in pin tract infections. Orthopedics 1991;14:305-308.
6. Masse A, Bruno A, Bosetti M, Biasibetti A, Cannas M, Gallinaro P. Prevention of pin track infection in external fixation with silver coated pins: Clinical and microbiological results. J Biomed Mater Res 2000;53:600-604.
7. David A, Pommer A, Eitenmuller J, Muhr G, Hahn MP. Animal experiment study of tensile strength of hydroxylapatite-coated AO/ASIF Schanz screws for external fixators. Unfallchirurg 1994;97:391-398.
8. Evans MJ, Kenwright J, Tanner KE. Analysis of single-sided external fracture fixation. J Mech Eng 1979;8:133-137.
9. Aron DN, Dewey CW. Application and postoperative management of external skeletal fixators. Vet Clin North Am Small Anim Pract 1992;22:69-97.
10. Capper M, Soutis C, Oni OO. Comparison of the stresses generated at the pin-bone interface by standard and conical external fixator pins. Biomaterials 1994;15:471-473.
11. Sisk TD. General principles and techniques of external skeletal fixation. Clin Orthop 1983:96-100.
12. Aro HT, Chao EY. Biomechanics and biology of fracture repair under external fixation. Hand Clin 1993;9:531-542.
13. Claes L, Eckert-Hubner K, Augat P. The effect of mechanical stability on local vascularization and tissue differentiation in callus healing. J Orthop Res 2002;20:1099-1105.
14. Hyldahl C, Pearson S, Tepic S, Perren SM. Induction and prevention of pin loosening in external fixation: An in vivo study on sheep tibiae. J Orthop Trauma 1991;5:485-492.
15. Pettine KA, Chao EY, Kelly PJ. Analysis of the external fixator pin-bone interface. Clin Orthop 1993:18-27.
16. Lind M, Overgaard S, Bunger C, Soballe K. Improved bone anchorage of hydroxypatite coated implants compared with tricalcium-phosphate coated implants in trabecular bone in dogs. Biomaterials 1999;20:803-808.
17. Lucke M, Schmidmaier G, Sadoni S, Wildemann B, Schiller R, Haas NP, Raschke M. Gentamycin coating of metallic implants reduces implant related osteomyelitis in rats. Bone 2003;32: 521-531.
18. Moroni A, Toksvig-Larsen S, Maltarello MC, Orienti L, Stea S, Giannini S. A comparison of hydroxyapatite-coated, titanium-coated, and uncoated tapered external-fixation pins. An in vivo study in sheep. J Bone Joint Surg [Am] 1998;80:547-554.
19. Caja VL, Moroni A. Hydroxyapatite coated external fixation pins: an experimental study. Clin Orthop 1996:269-275.
20. Magyar G, Toksvig-Larsen S, Moroni A. Hydroxyapatite coating of threaded pins enhances fixation. J Bone Joint Surg [Br] 1997;79:487-489.
21. Moroni A, Aspenberg P, Toksvig-Larsen S, Falzarano G, Giannini S. Enhanced fixation with hydroxyapatite coated pins. Clin Orthop 1998;346:171-177.
22. Schmidmaier G, Wildemann B, Bail H, Lucke M, Fuchs T, Stemberger A, Flyvbjerg A, Haas NP, Raschke M. Local application of growth factors (insulin-like growth factor-1 and transforming growth factor-beta 1) from a biodegradable poly(D,L-lactide) coating of osteosynthetic implants accelerates fracture healing in rats. Bone 2001;28:341-350.
23. Klein P, Schell H, Streitparth F, Heller M, Kassi JP, Kandziora F, Bragulla H, Haas NP, Duda GN. The initial phase of fracture healing is specifically sensitive to mechanical conditions. J Orthop Res 2003;21:662-669.
24. Schmidmaier G, Wildemann B, Stemberger A, Haas NP, Raschke M. Biodegradable poly(D,L-lactide) coating of implants for continuous release of growth factors. J Biomed Mater Res 2001;58:449-455.
25. Kulkarni RK, Moore EG, Hegyeli AF, Leonard F. Biodegradable poly(lactic acid) polymers. J Biomed Mater Res 1971;5: 169-181.
26. Kulkarni RK, Pani KC, Neuman C, Leonard F. Polylactic acid for surgical implants. Arch Surg 1966;93:839-843.
27. Kay MW, Roe SC, Stikeleather LF, Mahmoud A, Abrams CF. Axial vibration of threaded external fixation pins: Detection of pin loosening. Ann Biomed Eng 1998;26:361-368.
28. Bail HJ, Kolbeck S, Krummrey G, Schmidmaier G, Haas NP, Raschke MJ. Systemic application of growth hormone for enhancement of secondary and intramembranous fracture healing. Horm Res 2002;58:39-42.
29. Barka T, Anderson PJ. Histochemical methods for acid phosphatase using hexazonium pararosanilin as coupler. J Histochem Cytochem 1962;10:741-753.
30. Brunner E, Langer F. Nichtparametrische Analyse longitudinaler Daten. Universität Göttingen: R. Oldenbourg Verlag München; 1999. p 26-27.
31. Claes LE, Wilke HJ, Augat P, Rubenacker S, Margevicius KJ. Effect of dynamization on gap healing of diaphyseal fractures under external fixation. Clin Biomech (Bristol, Avon) 1995;10: 227-234.
32. Kenwright J, Goodship AE. Controlled mechanical stimulation in the treatment of tibial fractures. Clin Orthop 1989:36-47.
33. Raschke M, Wildemann B, Inden P, Bail H, Flyvbjerg A, Hoffmann J, Haas NP, Schmidmaier G. Insulin-like growth factor-1 and transforming growth factor-beta 1 accelerates osteotomy healing using polylactide-coated implants as a delivery system: A biomechanical and histological study in minipigs. Bone 2002;30:144-151.
34. D'Ercole AJ, Stiles AD, Underwood LE. Tissue concentrations of somatomedin C: Further evidence for multiple sites of synthesis and paracrine or autocrine mechanisms of action. Proc Natl Acad Sci USA 1984;81:935-939.
35. Lyons RM, Keski-Oja J, Moses HL. Proteolytic activation of latent transforming growth factor-beta from fibroblast-conditioned medium. J Cell Biol 1988;106:1659-1665.
36. Höntzsch D. Fixateur-externe-Montagen mit dem AO-Rohrsystem. OP-Journal 1997;13:18-21.
37. Duda GN, Eckert-Hubner K, Sokiranski R, Kreutner A, Miller R, Claes L. Analysis of inter-fragmentary movement as a function of musculoskeletal loading conditions in sheep. J Biomech 1998;31:201-210.
38. Biliouris TL, Schneider E, Rann BA, Gasser B, Perren SM. The effect of radial preload on the implant-bone interface: A cadaveric study. J Orthop Trauma 1989;3:323-332.
39. Beaupre GS, Orr TE, Carter DR. An approach for time-dependent bone modeling and remodeling-Theoretical development. J Orthop Res 1990;8:651-661.
40. Carter DR. Mechanical loading history and skeletal biology. J Biomech 1987;20:1095-1109.