Progression from normal glucose tolerance to type 2 diabetes in a young girl: Longitudinal changes in insulin sensitivity and secretion assessed by the clamp technique and surrogate estimates

Pediatric Diabetes

Volumn 6, Issue 2, 2005, Pages 95-99

  Saad, Rola ^a   Gungor, Neslihan ^a   Arslanian, Silva A ^a  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

First phase insulin; Glucose disposition index; Impaired glucose tolerance; Insulin resistance; Insulin secretion; Insulin sensitivity; Insulinogenic index; Normal glucose tolerance; Polycystic ovary syndrome; Type 2 diabetes

Indexed keywords

ADOLESCENT; AFRICAN AMERICAN; ARTICLE; CASE REPORT; DISEASE COURSE; DISEASE MARKER; FAMILY HISTORY; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; HIGH RISK PATIENT; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INSULIN DEFICIENCY; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; NON INSULIN DEPENDENT DIABETES MELLITUS; ORAL GLUCOSE TOLERANCE TEST; OVARY POLYCYSTIC DISEASE; PANCREAS ISLET BETA CELL; PATHOPHYSIOLOGY; PRIORITY JOURNAL;

BLOOD GLUCOSE; CHILD; DIABETES MELLITUS, TYPE 2; DISEASE PROGRESSION; FEMALE; FOLLOW-UP STUDIES; GLUCOSE CLAMP TECHNIQUE; HUMANS; INSULIN;

EID: 21444436738     PISSN: 1399543X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-543X.2005.00097.x     Document Type: Article

References (17)

1. Silink M, Kida K, Rosenbloom AL, eds. Type 2 Diabetes in Childhood and Adolescence: A Global Perspective. London: Martin Dunitz, 2003.
2. Arslanian S. Type 2 diabetes in children: clinical aspects and risk factors. Horm Res 2002: 57 (Suppl. 1): 19-28.
3. Arslanian SA, Lewy V, Danadian K, Saad R. Metformin therapy in obese adolescents with polycystic ovary syndrome and impaired glucose tolerance: Amelioration of exaggerated adrenal response to adrenocorticotropin with reduction of insulinemia/insulin resistance. J Clin Endocrinol Metab 2002: 87: 1555-1559.
4. Lewy V, Danadian D, Witchel S, Arslanian S. Early metabolic abnormalities in adolescent girls with polycystic ovarian syndrome. J Pediatr 2001: 138: 38-44.
5. Arslanian SA. Insulin resistance and insulin secretion in childhood and adolescence: their role in type 2 diabetes in youth. In: Silink M, Kida K, Rosenbloom AL, eds. Type 2 Diabetes in Childhood and Adolescence: A Global Perspective. London: Martin Dunitz, 2003: 93-116.
6. Bacha F, Gungor N, Saad R, Arslanian S. Adiponectin in youth. Diabetes Care 2004: 27: 547-552.
7. Gungor N, Saad R, Janosky J, Arslanian S. Validation of surrogate estimates of insulin sensitivity and insulin secretion in children and adolescents. J Pediatr 2004: 144: 47-55.
8. Jensen CC, Cnop M, Hull RL, Fujimoto WY, Kahn SE, American Diabetes Association GENNID Study Group. β-cell function is a major contributor to oral glucose tolerance in high-risk relatives of four ethnic groups in the U.S. Diabetes 2002: 41: 2170-2178.
9. Gerich JE. The genetic basis of type 2 diabetes mellitus: impaired insulin secretion versus impaired insulin sensitivity. Endocr Rev 1998: 19 (4): 491-503.
10. Weyer C, Borgardus C, Mott DM, Pratley RE. The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest 1999: 104: 787-794.
11. Tripathy D, Carlsson M, Almgren P et al. Insulin secretion and insulin sensitivity in relation to glucose tolerance: Lessons from the Botnia Study. Diabetes 2000: 49: 975-980.
12. Weyer C, Hanson RL, Tataranni PA, Bogardus C, Pratley RE. A high fasting plasma insulin concentration predicts type 2 diabetes independent of insulin resistance: evidence for a pathogenic role of relative hyperinsulinemia. Diabetes 2000: 49: 2094-2101.
13. McCance DR, Pettitt DJ, Hanson RL, Jacobsson LTH, Bennett PH, Knowler WC. Glucose, insulin concentrations and obesity in childhood and adolescence as predictors of NIDDM. Diabetologia 1994: 37: 617-623.
14. Zimmet PZ, Collins VR, Dowse GK, Knight LT. Hyperinsulinaemia in youth is a predictor of type 2 (non-insulin dependent) diabetes mellitus. Diabetologia 1992: 35: 534-541.
15. Edelstein S, Knowler WC, Bain RR et al. Predictors of progression from impaired glucose tolerance to NIDDM. An analysis of six prospective studies. Diabetes 1997: 46: 701-710.
16. Ferrannini E, Nannipieri M, Williams K, Gonzales C, Haffner SM, Stern MP. Mode of onset of type 2 diabetes from normal or impaired glucose tolerance. Diabetes 2004: 53: 160-165.
17. Arslanian SA, Lewy VD, Danadian K. Glucose intolerance in obese adolescents with polycystic ovary syndrome: roles of insulin resistance and β-cell dysfunction and risk of cardiovascular disease. J Clin Endocrinol Metab 2001, 2003: 86: 66-71.