How to identify gene-environment interactions in a multifactorial disease: CHD as an example

Proceedings of the Nutrition Society

Volumn 63, Issue 1, 2004, Pages 5-10

  Talmud, Philippa J ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

ADH3; Alcohol consumption; APOE; Diet; Gene environment interaction; Smoking

Indexed keywords

ALCOHOL DEHYDROGENASE; APOLIPOPROTEIN E;

ALCOHOL CONSUMPTION; ALLELE; CARDIOVASCULAR RISK; CONFERENCE PAPER; ENVIRONMENTAL FACTOR; GENE INTERACTION; GENE MUTATION; GENETIC ASSOCIATION; GENETIC IDENTIFICATION; GENETIC RISK; GENOTYPE; HEREDITY; HOMOZYGOTE; HUMAN; ISCHEMIC HEART DISEASE; SMOKING;

ALCOHOL DEHYDROGENASE; ALCOHOL DRINKING; ALLELES; APOLIPOPROTEINS E; CORONARY DISEASE; ENVIRONMENT; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MUTATION; SMOKING;

EID: 2142829281     PISSN: 00296651     EISSN: None     Source Type: Journal    
DOI: 10.1079/PNS2003311     Document Type: Conference Paper

References (23)

1. Abifadel M, Varret M, Rabes JP, Allard D, Ouguerram K, Devillers M et al. (2003) Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. Nature Genetics 34, 154-156.
2. Bosron WF, Lumeng L & Li TK (1988) Genetic polymorphism of enzymes of alcohol metabolism and susceptibility to alcoholic liver disease. Molecular Aspects of Medicine 10, 147-158.
3. Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL & Pericak-Vance MA (1993) Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261, 921-923.
4. Doll R & Hill AB (1966) Mortality of British doctors in relation to smoking; observation on coronary thrombosis. National Cancer Institute Monographs 19, 205-268.
5. Doll R, Peto R, Hall E, Wheatley K & Gray R (1997) Alcohol and coronary heart disease reduction among British doctors: confounding or causality? European Heart Journal 18, 23-25.
6. Fickl H, Van Antwerpen VL, Richards GA, Van der Westhuyzen DR, Davies N, Van der Walt R, Van der Merwe CA & Anderson R (1996) Increased levels of autoantibodies to cardiolipin and oxidised low density lipoprotein are inversely associated with plasma vitamin C status in cigarette smokers. Atherosclerosis 124, 75-81.
7. Ginsberg HN, Kris-Etherton P, Dennis B, Elmer PJ, Ershow A, Lefevre M, et al. (1998) Effects of reducing dietary saturated fatty acids on plasma lipids and lipoproteins in healthy subjects: the DELTA Study, protocol 1. Arteriosclerosis, Thrombosis and Vascular Biology 18, 441-449.
8. Goldstein JL & Brown MS (1989) Familial hypercholesterolemia. In The Metabolic Basis of Inherited Disease, 6th ed., pp. 1215-1250 [CH Scriver, AI Beaudet, WS Sly and D Valle, editors]. New York: McGraw-Hill Book Co.
9. Haskell WL (1986) The influence of exercise training on plasma lipids and lipoproteins in health and disease. Acta Medica Scandinavica 711, Suppl., 25-37.
10. Hines LM, Stampfer MJ, Ma J, Gaziano JM, Ridker PM, Hankinson SE, Sacks F, Rimm EB & Hunter DJ (2001) Genetic variation in alcohol dehydrogenase and the beneficial effect of moderate alcohol consumption on myocardial infarction. New England Journal of Medicine 344, 549-555.
11. Humphries SE, Hawe E, Dhammit S, Miller GJ & Talmud PJ (2003) In search of genetic precision. Lancet 361, 1908-1909.
12. Humphries SE, Talmud PJ, Hawe E, Bolla M, Day IN & Miller GI (2001) Apolipoprotein E4 and coronary heart disease in middle-aged men who smoke: a prospective study. Lancet 358, 115-119.
13. Innerarity TL, Mahley RW, Weisgraber KH, Bersot TP, Krauss RM, Vega GL, Grundy SM, Friedl W, Davignon J & McCarthy BJ (1990) Familial defective apolipoprotein B-100: a mutation of apolipoprotein B that causes hypercholesterolemia. Journal of Lipid Research 31, 1337-1349.
14. Ioannidis JP, Ntzani EE, Trikalinos TA & Contopoulos-Ioannidis DG (2001) Replication validity of genetic association studies. Nature Genetics 29, 306-309.
15. Jolivalt C, Leininger-Muller B, Bertrand P, Herber R, Christen Y & Siest G (2000) Differential oxidation of apolipoprotein E isoforms and interaction with phospholipids. Free Radical Biology in Medicine 28, 129-140.
16. Keavney B, Parish S, Palmer A, Clark S, Youngman L, Danesh I, McKenzie C, Delepine M, Lathrop M, Peto R & Collins R (2003) Large-scale evidence that the cardiotoxicity of smoking is not significantly modified by the apolipoprotein E epsilon 2/epsilon 3/epsilon 4 genotype. Lancet 361, 396-398.
17. Poirier J, Davignon J, BouthiUier D, Kogan S, Bertrand P & Gauthier S (1993) Apolipoprotein E polymorphism and Alzheimer's disease. Lancet 342, 697-699.
18. Rice KM & Holmans P (2003) Allowing for genotyping error in analysis of unmatched case-control studies. Annals of Human Genetics 67, 165-174.
19. Savolainen MJ & Kesaniemi YA (1995) Effects of alcohol on lipoproteins in relation to coronary heart disease. Current Opinion in Lipidology 6, 243-250.
20. Shields PG (2000) Epidemiology of tobacco carcinogenesis. Current Oncology Reports 2, 257-262.
21. Smith JD, Miyata M, Poulin SE, Neveux LM & Craig WY (1998) The relationship between apolipoprotein E and serum oxidation-related variables is apolipoprotein E phenotype dependent. International Journal of Clinical Laboratory Research 28, 116-121.
22. Wallace AJ, Mann JI, Sutherland WH, Williams S, Chisholm A, Skeaff CM, Gudnason V, Talmud PJ & Humphries SE (2000) Variants in the cholesterol ester transfer protein and lipoprotein lipase genes are predictors of plasma cholesterol response to dietary change. Atherosclerosis 152, 327-336.
23. Wilson PW, Schaefer EJ, Larson MG & Ordovas JM (1996) Apolipoprotein E alleles and risk of coronary disease. A meta-analysis. Arteriosclerosis, Thrombosis and Vascular Biology 16, 1250-1255.