Determination of adefovir in monkey plasma by liquid chromatography-tandem mass spectrometry

Yaoxue Xuebao

Volumn 38, Issue 2, 2003, Pages 120-123

  Zhao, Li Yan ^a   Chen, Xiao Yan ^a   Zhang, Yong ^a   Yang, Han Yu ^a   Zhong, Da Fang ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Adefovir; Adefovir dipivoxil; Liquid chromatography tandem mass spectrometry; Plasma concentration

Indexed keywords

ADEFOVIR; ADEFOVIR DIPIVOXIL; ADENINE; ANTIVIRUS AGENT; DRUG DERIVATIVE; PHOSPHONIC ACID DERIVATIVE;

ANIMAL; ARTICLE; BIOTRANSFORMATION; BLOOD; ELECTROSPRAY MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY; MACACA;

ADENINE; ANIMALS; ANTIVIRAL AGENTS; BIOTRANSFORMATION; CHROMATOGRAPHY, LIQUID; MACACA MULATTA; PHOSPHONIC ACIDS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 2142743312     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. Benhamon Y, Bochet M, Thibault V, et al. Safety and efficacy of adefovir dipivoxil in patients co-infected with HIV-1 and lamivudine-resistant hepatitis B virus: an open-label pilot study [J]. Lancet, 2001,358(9283):718-723.
2. Cundy KC, Fishback JA, Shaw JP, et al. Oral bioavailability of the antiretroviral agent 9-(2-phosphonylmethoxyethyl) adenine (PMEA) from three formulations of the prodrug bis (pivaloyloxymethyl)-PMEA in fasted male cynomolgus monkeys [J]. Pharm Res, 1994,11(6):839-843.
3. Russell JW, Marrero D, Whiterock VJ, et al. Determination of 9-[(2-phosphonylmethoxy)ethyl] adenine in rat urine by high-performance liquid chromatography with fluorescence detection [J]. J Chromatogr B, 1991,572(1-2):321-326.
4. Naesens L, Balzarini J, Clercq ED. Acyclic adenine nucleoside phosphonates in plasma determined by high-performance liquid chromatography with fluorescence detection [J]. Clin Chem, 1992,38(4):480-485.
5. Sparidans RW, Veldkamp A, Hoetelmans RMW, et al. Improved and simplified liquid chromatographic assay for adefovir, a novel antiviral drug, in human plasma using derivatization with chloroacetaldehyde [J]. J Chromatogr B, 1999,736(1-2):115-121.
6. Zhong DF. Some aspects in establishing standard curves in bioanalyses with the weighted least squires method [J]. Chin J Pharm Anal, 1996,16(5):343-346.
7. Karnes HT, March C. Precision, accuracy, and data acceptance criteria in biopharmaceutical analysis [J]. Pharm Res, 1993,10(10):1420-1426.