Synthesis and anticonvulsant activity of N-3 substituted 2,3-benzodiazepines

Farmaco

Volumn 59, Issue 5, 2004, Pages 353-358

  Quartarone, Silvana ^a,c   Caruso, Roberta ^a   Orlando, Valèrie ^a   Russo, Emilio ^b   De Sarro, Giovambattista ^b   Chimirri, Alba ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^c NONE   (Italy)

Author keywords

3 alkylcarbamoyl 1 aryl 3,5 dihydro 7,8 dimethoxy 4H 2,3 benzodiazepin 4 ones; AMPA receptor antagonists; Anticonvulsant agents

Indexed keywords

1 (4 AMINOPHENYL) 4 METHYL 7,8 METHYLENEDIOXY 5H 2,3 BENZODIAZEPINE; 1 (4' AMINOPHENYL) 3,5 DIHYDRO 7,8 DIMETHOXY 4H 2,3 BENZODIAZEPIN 4 ONE; 3 BUTYLCARBAMOYL 3,5 DIHYDRO 7,8 DIMETHOXY 1 (3' NITROPHENYL) 4H 2,3 BENZODIAZEPIN 4 ONE; 3 BUTYLCARBAMOYL 3,5 DIHYDRO 7,8 DIMETHOXY 1 (4' FLUOROPHENYL) 4H 2,3 BENZODIAZEPIN 4 ONE; 3 BUTYLCARBAMOYL 3,5 DIHYDRO 7,8 DIMETHOXY 1 (4' NITROPHENYL) 4H 2,3 BENZODIAZEPIN 4 ONE; 3 BUTYLCARBAMOYL 3,5 DIHYDRO 7,8 DIMETHOXY 1 PHENYL 4H 2,3 BENZODIAZEPIN 4 ONE; 3,5 DIHYDRO 7,8 DIMETHOXY 1 (3' NITROPHENYL) 3 PROPYLCARBAMOYL 4H 2,3 BENZODIAZEPIN 4 ONE; 3,5 DIHYDRO 7,8 DIMETHOXY 1 (4' FLUOROPHENYL) 3 METHYLCARBAMOYL 1 PHENYL 4H 2,3 BENZODIAZEPIN 4 ONE; 3,5 DIHYDRO 7,8 DIMETHOXY 1 (4' FLUOROPHENYL) 3 PROPYLCARBAMOYL 4H 2,3 BENZODIAZEPIN 4 ONE; 3,5 DIHYDRO 7,8 DIMETHOXY 1 (4' NITROPHENYL) 3 PROPYLCARBAMOYL 4H 2,3 BENZODIAZEPIN 4 ONE; 3,5 DIHYDRO 7,8 DIMETHOXY 1 PHENYL 3 PROPYLCARBAMOYL 4H 2,3 BENZODIAZEPIN 4 ONE; 3,5 DIHYDRO 7,8 DIMETHOXY 3 ETHYLCARBAMOYL 1 (3' NITROPHENYL) 4H 2,3 BENZODIAZEPIN 4 ONE; 3,5 DIHYDRO 7,8 DIMETHOXY 3 ETHYLCARBAMOYL 1 (4' FLUOROPHENYL) 4H 2,3 BENZODIAZEPIN 4 ONE; 3,5 DIHYDRO 7,8 DIMETHOXY 3 ETHYLCARBAMOYL 1 (4' NITROPHENYL) 4H 2,3 BENZODIAZEPIN 4 ONE; 3,5 DIHYDRO 7,8 DIMETHOXY 3 ETHYLCARBAMOYL 1 PHENYL 4H 2,3 BENZODIAZEPIN 4 ONE; 3,5 DIHYDRO 7,8 DIMETHOXY 3 METHYLCARBAMOYL 1 (3' NITROPHENYL) 4H 2,3 BENZODIAZEPIN 4 ONE; 3,5 DIHYDRO 7,8 DIMETHOXY 3 METHYLCARBAMOYL 1 (4' NITROPHENYL) 4H 2,3 BENZODIAZEPIN 4 ONE; 3,5 DIHYDRO 7,8 DIMETHOXY 3 METHYLCARBAMOYL 1 PHENYL 4H 2,3 BENZODIAZEPIN 4 ONE; AMPA RECEPTOR ANTAGONIST; ANTICONVULSIVE AGENT; BENZODIAZEPINE DERIVATIVE; CFM 2; GLUTAMATE RECEPTOR ANTAGONIST; TALAMPANEL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTICONVULSANT ACTIVITY; ARTICLE; AUDITORY STIMULATION; CONTROLLED STUDY; DRUG SYNTHESIS; MOUSE; NONHUMAN; SEIZURE; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-ANXIETY AGENTS; ANTICONVULSANTS; BENZODIAZEPINES; MICE; MICE, INBRED DBA; RECEPTORS, AMPA; SEIZURES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 2142726012     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.farmac.2004.01.005     Document Type: Article

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