Thermodynamics of partitioning of phenothiazine drugs between phosphatidylcholine bilayer vesicles and water studied by second-derivative spectrophotometry

Chemical and Pharmaceutical Bulletin

Volumn 51, Issue 9, 2003, Pages 1056-1059

  Takegami, Shigehiko ^a   Kitamura, Keisuke ^a   Kitade, Tatsuya ^a   Kitagawa, A ^a   Kawamura, Kikuko ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Liposome; Partition coefficient; Phenothiazine; Second derivative spectrophotometry; Thermodynamics

Indexed keywords

ALKYL GROUP; BUFFER; CHLORPROMAZINE; HALOGEN; PHENOTHIAZINE DERIVATIVE; PHOSPHATE; PHOSPHATIDYLCHOLINE; PROMAZINE; TRIFLUOPERAZINE; TRIFLUPROMAZINE; WATER; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; PHOSPHORUS;

ARTICLE; BILAYER MEMBRANE; CORRELATION ANALYSIS; ENTHALPY; ENTROPY; HYDROPHOBICITY; MATHEMATICAL COMPUTING; MOLECULAR MECHANICS; PARTITION COEFFICIENT; PH MEASUREMENT; SIGNAL TRANSDUCTION; SPECTROPHOTOMETRY; TEMPERATURE DEPENDENCE; THERMODYNAMICS; ABSORPTION; ALGORITHM; CHEMISTRY; LIPID BILAYER; PH; PHYSICAL CHEMISTRY; SOLUBILITY; TEMPERATURE;

ABSORPTION; ALGORITHMS; CHEMISTRY, PHYSICAL; ENTROPY; HYDROGEN-ION CONCENTRATION; INDICATORS AND REAGENTS; LIPID BILAYERS; PHENOTHIAZINES; PHOSPHATIDYLCHOLINES; PHOSPHORUS; SOLUBILITY; TEMPERATURE; THERMODYNAMICS; WATER;

EID: 2142717276     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.51.1056     Document Type: Article

References (24)

1. Ahmed A. M. S., Farah F. H., Kellaway I. W., Pharm. Res., 1, 119-124 (1985).
2. Betageri G. V., Rogers J. A., Int. J. Pharmaceut., 36, 165-173 (1987).
3. Betageri G. V., Rogers J. A., J. Pharm. Phrmacol., 45, 931-933 (1993).
4. Betageri G. V., Nayernama A., Habib M. J., Int'l. J. of Pharm. Advances, 1, 310-319 (1996).
5. Keller M., Kerth A., Blume A., Biochim. Biophys. Acta, 1326, 178-198 (1997).
6. Go M. L., Ngian T. L., Chem. Pharm. Bull., 45, 2055-2060 (1997).
7. Choi Y. W., Rogers J. A., Pharm. Res., 7, 508-512 (1990).
8. Fujiwara H., Da Y. Z., Ito K., Takagi T., Nishioka Y., Bull. Chem. Soc. Jpn., 64, 3707-3712 (1991).
9. Rogers J. A., Choi Y. W., Pharm. Res., 10, 913-917 (1993).
10. Kitamura K., Imayoshi N., Goto T., Shiro H., Mano T., Nakai Y., Anal. Chim. Acta, 304, 101-106 (1995).
11. Takegami S., Kitamura K., Kitade T., Hasegawa K., Nishihira A., J. Coll. Interf. Sci., 220, 81-87 (1999).
12. Kitamura K., Takenaka M., Yoshida S., Ito M., Nakamura Y., Hozumi K., Anal. Chim. Acta, 242, 131-135 (1991).
13. Kitamura K., Kitade T., Mabuchi M., Mizuochi M., Goto K., Bunseki Kagaku, 42, 581-585 (1993).
14. Bondy B., Remien J., Life Sci., 28, 441-449 (1981).
15. Luxnat M., Galla H. J., Biochim. Biophys. Acta, 856, 274-282 (1986).
16. Zachowski A., Durand P., Biochim. Biophys. Acta, 937, 411-416 (1988).
17. Welti R., Mullikin L. J., Yoshimura T., Helmkamp G. M., Jr., Biochemistry, 23, 6086-6091 (1984).
18. Christopher A. J., Fennell T. R. F. W., Microchem. J., 12, 593-605 (1967).
19. Savitzky A., Golay M. J. E., Anal. Chem., 36, 1627-1639 (1964).
20. Kitamura K., Hozumi K., Anal. Chim. Acta, 172, 111-118 (1985).
21. Connors K. A., "Binding Constants," John Wiley & Sons, New York, 1987, pp. 142-147.
22. Pliska V., Testa B., Van de Waterbeemd H., "Lipophilicity in Drug Action and Toxicology," VCH, Germany, 1996, pp. 285-290.
23. Aki H., Yamamoto M., J. Pharm. Pharmacol., 42, 637-641 (1990).
24. Leffler J. E., Grunwald E., "Rates and Equilibria of Organic Reactions," John Wiley & Sons, New York, 1963, pp. 128-314.