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PID: 11583750, COI: 1:CAS:528:DC%2BD3MXntF2qtbw%3D, This EORTC trial randomized a total of 85 patients with advanced kidney cancer (with an excellent performance status) to receive nephrectomy followed by interferon α-2b or interferon α-2b alone. this small study, the time to progression (5 versus 3 months) and median duration of survival (17 versus 7 months) were significantly better the patients undergoing a nephrectomy before immunotherapy. This trial provides a background to pursue a larger randomized trial to determine if nephrectomy before immunotherapy prolongs survival patients with metastatic kidney cancer
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Mickisch GH, Garin A, van Poppel H, et al.: Radical nephrectomy plus interferon-alpha-based immunotherapy compared with interferon alpha alone in metastatic renal-cell carcinoma: a randomized trial. Lancet 2001, 358:966–970. This EORTC trial randomized a total of 85 patients with advanced kidney cancer (with an excellent performance status) to receive nephrectomy followed by interferon α-2b or interferon α-2b alone. In this small study, the time to progression (5 versus 3 months) and median duration of survival (17 versus 7 months) were significantly better in the patients undergoing a nephrectomy before immunotherapy. This trial provides a background to pursue a larger randomized trial to determine if nephrectomy before immunotherapy prolongs survival in patients with metastatic kidney cancer. DOI: 10.1016/S0140-6736(01)06103-7
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This article presents the data from the Southwest Oncology Group’s (SWOG) 8949 trial that randomized 246 patients to nephrectomy followed by α-2b or interferon α-2b alone. The median survival was 11.1 months the nephrectomy-plus-interferon arm versus 8.1 months (P = 0.05) the interferon alone arm. This trial supports the use of nephrectomy before immunotherapy patients with advanced kidney cancer who have an excellent PS (PS of 0 or 1
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Flannigan RC, Salmon SE, Blumenstein BA, et al.: Nephrectomy followed by interferon alpha-2b compared with interferon alpha-2b alone for metastatic renal-cell cancer. N Engl J Med 2001, 345:1655–1659. This article presents the data from the Southwest Oncology Group’s (SWOG) 8949 trial that randomized 246 patients to nephrectomy followed by α-2b or interferon α-2b alone. The median survival was 11.1 months in the nephrectomy-plus-interferon arm versus 8.1 months (P = 0.05) in the interferon alone arm. This trial supports the use of nephrectomy before immunotherapy in patients with advanced kidney cancer who have an excellent PS (PS of 0 or 1). DOI: 10.1056/NEJMoa003013
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Removing the primary tumor after the cancer has spread
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PID: 11759650, COI: 1:STN:280:DC%2BD38%2FivFOhsA%3D%3D, this editorial, Tannock succinctly presents the main criticisms of the SWOG 8949 trial, which randomized patients to receive nephrectomy before interferon versus interferon alone. The incredibly slow accrual to this important trial raises the concern whether these results are applicable to the overall population of patients with advanced kidney cancer. It also is unclear why the patients who had a reduction their tumor burden (via nephrectomy) essentially had the same response rate to interferon (3.3%) as those treated with interferon alone (3.6%). More patients the interferon only arm had a worse PS (PS of 1) than those who were randomized to nephrectomy followed by immunotherapy
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Tannock IF: Removing the primary tumor after the cancer has spread. N Engl J Med 2001, 345:1699–1700. In this editorial, Tannock succinctly presents the main criticisms of the SWOG 8949 trial, which randomized patients to receive nephrectomy before interferon versus interferon alone. The incredibly slow accrual to this important trial raises the concern whether these results are applicable to the overall population of patients with advanced kidney cancer. It also is unclear why the patients who had a reduction in their tumor burden (via nephrectomy) essentially had the same response rate to interferon (3.3%) as those treated with interferon alone (3.6%). More patients in the interferon only arm had a worse PS (PS of 1) than those who were randomized to nephrectomy followed by immunotherapy. DOI: 10.1056/NEJM200112063452310
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