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Volumn 5, Issue 1, 2004, Pages 19-24

A medical oncologist’s approach to immunotherapy for advanced renal tumors: Is nephrectomy indicated?

Author keywords

Clin Oncol; Kidney Cancer; Metastatic Renal Cell Carcinoma; Papillary Renal Cell Carcinoma; Renal Cell Carcinoma

Indexed keywords

ANTINEOPLASTIC AGENT; INTERFERON;

EID: 2142699517     PISSN: 15272737     EISSN: 15346285     Source Type: Journal    
DOI: 10.1007/s11934-004-0006-x     Document Type: Article
Times cited : (2)

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    • PID: 11759650, COI: 1:STN:280:DC%2BD38%2FivFOhsA%3D%3D, this editorial, Tannock succinctly presents the main criticisms of the SWOG 8949 trial, which randomized patients to receive nephrectomy before interferon versus interferon alone. The incredibly slow accrual to this important trial raises the concern whether these results are applicable to the overall population of patients with advanced kidney cancer. It also is unclear why the patients who had a reduction their tumor burden (via nephrectomy) essentially had the same response rate to interferon (3.3%) as those treated with interferon alone (3.6%). More patients the interferon only arm had a worse PS (PS of 1) than those who were randomized to nephrectomy followed by immunotherapy
    • Tannock IF: Removing the primary tumor after the cancer has spread. N Engl J Med 2001, 345:1699–1700. In this editorial, Tannock succinctly presents the main criticisms of the SWOG 8949 trial, which randomized patients to receive nephrectomy before interferon versus interferon alone. The incredibly slow accrual to this important trial raises the concern whether these results are applicable to the overall population of patients with advanced kidney cancer. It also is unclear why the patients who had a reduction in their tumor burden (via nephrectomy) essentially had the same response rate to interferon (3.3%) as those treated with interferon alone (3.6%). More patients in the interferon only arm had a worse PS (PS of 1) than those who were randomized to nephrectomy followed by immunotherapy. DOI: 10.1056/NEJM200112063452310
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.