Interferon-γ inhibits in situ expression of PDGF-β mRNA by smooth muscle cells in injured rabbit arteries after transluminal balloon angioplasty

Chinese Medical Journal

Volumn 114, Issue 2, 2001, Pages 139-142

  Ji, Jun ^a   Si, Lüsheng ^a   Fang, Weihua ^a   Ling, Wenping ^a  

^a Shenzhen Sunyixian Cardiovasc Hosp   (China)

Author keywords

Interferon gamma; PDGF mRNA; Proliferating cell nuclear antigen; Restenosis; Smooth muscle cells

Indexed keywords

CYCLINE; GAMMA INTERFERON; MESSENGER RNA; PLATELET DERIVED GROWTH FACTOR;

ANIMAL; ARTERY; ARTICLE; BIOSYNTHESIS; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; IN SITU HYBRIDIZATION; INJURY; INTIMA; MALE; METABOLISM; PATHOLOGY; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; RABBIT; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE;

ANGIOPLASTY, BALLOON; ANIMALS; ARTERIES; ENDOTHELIUM, VASCULAR; GENE EXPRESSION REGULATION; IN SITU HYBRIDIZATION; INTERFERON TYPE II; MALE; MUSCLE, SMOOTH, VASCULAR; PLATELET-DERIVED GROWTH FACTOR; PROLIFERATING CELL NUCLEAR ANTIGEN; RABBITS; RNA, MESSENGER; TUNICA INTIMA;

EID: 0035262193     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. Wilcox JN. Molecular biology: insight into the causes and prevention of restenosis after arterial intervention. Am J Cardiol 1993;72:88E-95E.
2. Shimokado K, Yokota T, Kato N, et al. Bidirectional regulation of smooth muscle cell proliferation by IFN-gamma. J Atheroscler Thromb 1994;1(Suppl 1):S29-S33.
3. Hart CE, Clowes AW. Platelet-derived growth factor and arterial response to injury. Circulation 1997;95:555-556.
4. Lindner V, Giachelli CM, Schwartz SM, et al. A subpopulation of smooth muscle cells in injured rat arteries expresses platelet-derived growth factor-β chain mRNA. Circ Res 1995;76:951-957.
5. Uchida K, Sasahara M, Morigami N, et al. Expression of platelet-derived growth factor β-chain in neointimal smooth muscle cells of balloon injured rabbit femoral arteries. Atherosclerosis 1996;124: 9-23.
6. Warner SJ, Friedman GB, Libby P. Immune interferon inhibits proliferation and induces 2′-5′-oligoadenylate synthetase gene expression in human vascular smooth muscle cells. J Clin Invest 1989;83:1174-1182.
7. Beasley D, McGuiggin M. Interleukin 1 activates soluble guanylate cyclase in human vascular smooth muscle cells through a novel nitric oxide-independent pathway. J Exp Med 1994;179:71-80.