Upregulation of transforming growth factor-beta and interleukin-10 in cows with clinical Johne's disease

Veterinary Immunology and Immunopathology

Volumn 99, Issue 1-2, 2004, Pages 39-46

  Khalifeh, M S ^a   Stabel, J R ^a  

^a AGRICULTURAL RESEARCH SERVICE   (United States)

Author keywords

Cytokines; IFN ; IL 10; Immunity; interferon ; interleukin 10; Johne's disease; Mycobacterium paratuberculosis; reverse transcriptase polymerase chain reaction; RT PCR; TGF ; transforming growth factor beta

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; COW; DOWN REGULATION; GENE EXPRESSION; ILEUM; LYMPH NODE; MESENTERY LYMPH NODE; NONHUMAN; PARATUBERCULOSIS; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SAMPLE; STATISTICAL SIGNIFICANCE; TISSUE SECTION; UPREGULATION;

ANIMALS; CATTLE; CATTLE DISEASES; FEMALE; ILEUM; IMMUNOHISTOCHEMISTRY; INTERFERON TYPE II; INTERLEUKIN-10; MYCOBACTERIUM PARATUBERCULOSIS; PARATUBERCULOSIS; RETROSPECTIVE STUDIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; TRANSFORMING GROWTH FACTOR BETA;

ANIMALIA; MYCOBACTERIUM; MYCOBACTERIUM AVIUM; MYCOBACTERIUM AVIUM SUBSP. PARATUBERCULOSIS;

EID: 2142657781     PISSN: 01652427     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetimm.2004.01.009     Document Type: Article

References (20)

1. Bermudez L.E. Production of transforming growth factor-beta by Mycobacterium avium-infected human macrophages is associated with unresponsiveness to IFN-gamma. J. Immunol. 150:1993;1838-1845
2. Cerretti D.P., McKereghan K., Larsen A., Cosman D., Gillis S., Baker P.E. Cloning, sequence, and expression of bovine interferon-gamma. J. Immunol. 136:1986;4561-4564
3. Chen Y., Kuchroo V.K., Inobe J., Hafler D.A., Weiner H.L. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science. 265:1994;1237-1240
4. Cocito C., Gilot P., Coene M., de Kesel M., Poupart P., Vannuffel P. Paratuberculosis. Clin. Microbiol. Rev. 7:1994;328-345
5. Flesch I.E., Hess J.H., Oswald I.P., Kaufmann S.H. Growth inhibition of Mycobacterium bovis by IFN-gamma stimulated macrophages: regulation by endogenous tumor necrosis factor-alpha and by IL-10. Int. Immunol. 6:1994;693-700
6. Groux H., O'Garra A., Bigler M., Rouleau M., Antonenko S., de Vries J.E., Roncarolo M.G. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature. 389:1997;737-742
7. Hirsch C.S., Yoneda T., Averill L., Ellner J.J., Toossi Z. Enhancement of intracellular growth of Mycobacterium tuberculosis in human monocytes by transforming growth factor-beta-1. J. Infect. Dis. 170:1994;1229-1237
8. Hutchinson L.J. Economic impact of paratuberculosis. Vet. Clin. N. Am. Food Anim. Pract. 12:1996;373-381
9. Murray P.J., Wang L., Onufryk C., Tepper R.I., Young R.A. T cell-derived IL-10 antagonizes macrophage function in mycobacterial infection. J. Immunol. 158:1997;315-321
10. Murray P.J., Young R.A. Increased antimycobacterial immunity in interleukin-10-deficient mice. Infect. Immun. 67:1999;3087-3095
11. Othieno C., Hirsch C.S., Hamilton B.D., Wilkinson K., Ellner J.J., Toossi Z. Interaction of Mycobacterium tuberculosis-induced transforming growth factor beta1 and interleukin-10. Infect. Immun. 67:1999;5730-5735
12. Plath A., Einspanier R., Peters F., Sinowatz F., Schams D. Expression of transforming growth factors alpha and beta-1 messenger RNA in the bovine mammary gland during different stages of development and lactation. J. Endocrinol. 155:1997;501-511
13. Roach D.R., Martin E., Bean A.G., Rennick D.M., Briscoe H., Britton W.J. Endogenous inhibition of antimycobacterial immunity by IL-10 varies between mycobacterial species. Scand. J. Immunol. 54:2001;163-170
14. Stabel J.R. Production of gamma-interferon by peripheral blood mononuclear cells: an important diagnostic tool for detection of subclinical paratuberculosis. J. Vet. Diagn. Invest. 8:1996;345-350
15. Stabel J.R. Cytokine secretion by peripheral blood mononuclear cells from cows infected with Mycobacterium paratuberculosis. Am. J. Vet. Res. 61:2000;754-760
16. Sweeney R.W., Jones D.E., Habecker P., Scott P. Interferon-gamma and interleukin 4 gene expression in cows infected with Mycobacterium paratuberculosis. Am. J. Vet. Res. 59:1998;842-847
17. Sweeney R.W., Whitlock R.H., Rosenberger A.E. Mycobacterium paratuberculosis cultured from milk and supramammary lymph nodes of infected asymptomatic cows. J. Clin. Microbiol. 30:1992;166-171
18. Sweeney R.W., Whitlock R.H., Rosenberger A.E. Mycobacterium paratuberculosis isolated from fetuses of infected cows not manifesting signs of the disease. Am. J. Vet. Res. 53:1992;477-480
19. Weiss D.J., Evanson O.A., Moritz A., Deng M.Q., Abrahamsen M.S. Differential responses of bovine macrophages to Mycobacterium avium subsp. paratuberculosis and Mycobacterium avium subsp. avium. Infect. Immun. 70:2002;5556-5561
20. Yamamura M., Uyemura K., Deans R.J., Weinberg K., Rea T.H., Bloom B.R., Modlin R.L. Defining protective responses to pathogens: cytokine profiles in leprosy lesions. Science. 254:1991;277-279