Severe early onset osteopenia and osteoporosis caused by antiepileptic drugs

Netherlands Journal of Medicine

Volumn 63, Issue 6, 2005, Pages 222-226

  Beerhorst, K ^a   Huvers, F C ^b   Renier, W O ^b  

^a CANISIUS WILHELMINA HOSPITAL   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Antiepileptic drugs; Epilepsy; Osteopenia; Osteoporosis

Indexed keywords

ALENDRONIC ACID; ANTICONVULSIVE AGENT; CALCITRIOL; CARBAMAZEPINE; ETHOSUXIMIDE; LAMOTRIGINE; OXCARBAZEPINE; PHENOBARBITAL; PHENYTOIN; VALPROIC ACID;

ADULT; ANTICONVULSANT THERAPY; ARTICLE; BONE BIOPSY; BONE DENSITY; CASE REPORT; CLINICAL PROTOCOL; DISEASE COURSE; DISEASE SEVERITY; DUAL ENERGY X RAY ABSORPTIOMETRY; EPILEPSY; FEMALE; HEALTH CARE ORGANIZATION; HUMAN; LONG TERM CARE; MALE; ONSET AGE; OSTEOPENIA; OSTEOPOROSIS; PELVIS FRACTURE; PRACTICE GUIDELINE; TONIC CLONIC SEIZURE; VERTEBRA FRACTURE;

ADULT; ANTICONVULSANTS; BODY MASS INDEX; BONE DENSITY; BONE DISEASES, METABOLIC; DENSITOMETRY, X-RAY; EPILEPSY, TONIC-CLONIC; FEMALE; HUMANS; MALE; OSTEOPOROSIS; TIME FACTORS;

EID: 21344474799     PISSN: 03002977     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Meinardi H, Deckers CLP, Hekster YA, et al. Praktische keuzecriteria voor anti-epileptica. Alphen aan de Rijn: Van Zuiden Communications, 1999.
2. Andress DL, Ozuna J, Tirschwell D, et al. Antiepileptic drug-induced bone loss in young male patients who have seizures. Arch Neurol 2002;59:781-6.
3. Hahn TJ. Bone complications of anticonvulsants. Drugs 1976;12:201-11.
4. 3 administration. Calcif Tissue Int 1979;27:13-8.
5. Hahn TJ. Drug-induced disorders of vitamin D and mineral metabolism. Clin Endocrin Metab 1980;9:107-27.
6. Richens A, Rowe DJ. Disturbance of calcium metabolism by anticonvulsant drugs. BMJ 1970;4:73-6.
7. Christiansen C, Rodbro P, Tjellesen L. Pathophysiology behind anticonvulsant osteomalacia. Acta Neurol Scan Suppl 1983;94:21-8.
8. Farhat G, Yamout B, Mikati MA, Demirjian S, Sawaya R, El Hajj FG. Effect of anti-epileptic drugs on bone density in ambulatory patients. Neurology 2002;58:1348-53.
9. Sheth RD. Bone health in epilepsy. Epilepsia 2002;43:1453-54.
10. Stephen LJ, McLellan AR, Harrison JH, et al. Bone density and antiepileptic drugs: a case-controlled study. Seizure 1999;8:339-42.
11. Hamersvelt HW. Brains and bones. Nephrol Dial Transplant 1998;13:801-2.
12. Van Daele PLA, Pols HAP. Metabole botafwijkingen bij maag-, darm-, en leverziekten. Ned Tijdschr Geneeskd 2000;144:462-7.
13. Haussler MR, McCain TA. Basic and clinical concepts related to vitamin D metabolism and action (second of two parts). N Engl J Med 1977;297:1041-50.
14. Wauters IM, van Soesbergen RM. Disease caused by lack of sunlight: rickets and osteomalacia. Ned Tijdschr Geneeskd 1999;143:593-7.
15. Sato Y, Kondo I, Ishida S, et al. Decreased bone mass and increased bone turnover with valproate therapy in adults with epilepsy. Neurology 2001;57:445-9.
16. Dent CE, Richens A, Rowe DJ, Stamp TC. Osteomalacia with long-term anticonvulsant therapy in epilepsy. BMJ 1970;4:69-72.
17. Kroger H, Kotaniemi A, Vainio P, Alhava E. Bone densitometry of the spine and femur in children by dual-energy x-ray absorptiometry. Bone Miner 1992;17:75-85.
18. Sheth RD, Wesolowski CA, Jacob JC, et al. Effect of carbamazepine and valproate on bone mineral density. J Pediatr 1995;127:256-62.
19. Verrotti A, Greco R, Latini G, Morgese G, Chiarelli F. Increased bone turnover in prepubertal, pubertal, and postpubertal patients receiving carbamazepine. Epilepsia 2002;43:1488-92.
20. Perucca E. Pharmacokinetic interactions with antiepileptic drugs. Clin Pharmacokinet 1982;7:57-84.
21. Henderson RC, Lark RK, Gurka MJ, et al. Bone density and metabolism in children and adolescents with moderate to severe cerebral palsy. Pediatrics 2002;110(1 Pt 1):e5.
22. Rasgon N. The relationship between polycystic ovary syndrome and antiepileptic drugs; a review of the evidence. J Clin Psychopharmacol 2004;24(3):322-34.
23. Gezondheidsraad. Voedingsnormen: calcium, vitamine D, thiamine, riboflavine, nacine, pantotheenzuur en biotine. Nr. 2000/12 ed. Den Haag: 2000.
24. Valmadrid C, Voorhees C, Litt B, Schneyer CR. Practice patterns of neurologists regarding bone and mineral effects of antiepileptic drug therapy. Arch Neurol 2001;58:1369-74.
25. Van de Bergh JP, Smals AG, Schweitzer DH, Hermus AR. Ultrasound measurement of calcaneus: a promising method for prediction of osteoporotic fractures. Ned Tijdschr Geneeskd 2001;145:1105-9.
26. Pedrera JD, Canal ML, Carvajal J, et al. Influence of vitamin D administration on bone ultrasound measurements in patients on anticonvulsant therapy. Eur J Clin Invest 2000;30:895-9.
27. Kwaliteitsinstituut voor de Gezondheidszorg CBO. Tweede herziene richtlijn osteoporose. Alphen aan de rijn: Van Zuiden Communications, 2002.
28. Assessment of osteoporotic fracture risk and its application to screening for postmenopausal osteoporosis. Report of a WHO Study Group. World Health Organ Tech Rep Ser 1994;843:1-129.