Effective inhibition of expression of hepatitis B virus genes by DNAzymes

World Journal of Gastroenterology

Volumn 11, Issue 23, 2005, Pages 3504-3507

  Wo, Jian Er ^a,b   Wu, Xiao Ling ^c   Zhou, Lin Fu ^a,b   Yao, Hang Ping ^a,b   Chen, Li Wei ^a,b   Dennin, Reinhard H ^d  

^a BEIJING HOSPITAL   (China)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c Division of Plastic Surgery   (China)

^d UNIVERSITY OF LÜBECK   (Germany)

Author keywords

DNAzyme; Gene expression; HBV; Inhibition

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; DEOXYRIBOZYME; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B(E) ANTIGEN; VIRUS DNA;

ARTICLE; CELL CULTURE; CELL STRAIN; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; DRUG SPECIFICITY; HEPATITIS B VIRUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; VIRUS GENOME; VIRUS REPLICATION;

EID: 21344469258     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v11.i23.3504     Document Type: Article

References (8)

1. Santoro SW Joyce GF. A general purpose RNA-cleaving DNA enzyme. Proc Natl Acad Sci USA 1997; 94: 4262-4266
2. Breaker RR. Making catalytic DNAs. Science 2000; 290: 2095-2096
3. Khachigian LM. Catalytic DNAs as potential therapeutic agents and sequence-specific molecular tools to dissect biological function. J Clin Invest 2000; 106: 1189-1195
4. Cairns MJ Hopkins TM,Witherington C, Wang L, Sun LQ. Target site selection for an RNA-cleaving catalytic DNA. Nat Biotech 1999; 17: 480-486
5. Unwalla H Banerjea AC. Inhibition of HIV-1gene expression by nove macrophage-tropic DNA enzymes targeted to cleave HIV-1 TAT/Rev RNA. Biochem J 2001; 357: 147-155
6. Morrisey DV Lee PA, Johnson DA, Overly SL, McSwiggen JA, Beigelman L, Mokler VR, Maloney L, Vargeese C, Bowman K, O'Brien JT, Shaffer CS, Conrad A, Schmid P, Morrey JD, Macejak DG, Pavco PA, Blatt LM. Characterization of nuclease-resistant ribozymes directed against hepatitis B virus RNA. J Viral Hepatitis 2002; 9: 411-418
7. Sells MA Chen ML, Acs G. Production of hepatitis B virus particles in Hep G2 cells transfected with cloned hepatitis B virus DNA. Proc Natl Acad Sci USA 1987; 84: 1005-1009
8. Sells MA Zelent AZ, Shvartsman M, Acs G. Replicative intermediates of hepatitis B virus in HepG2 cells that produce infectious virions. J Virol 1988; 62: 2836-2844