Cell signaling: Elementary response of olfactory receptor neurons to odorants

Science

Volumn 308, Issue 5730, 2005, Pages 1931-1934

  Bhandawat, Vikas ^a   Reisert, Johannes ^a   Yau, King Wai ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CELLS; ISOMERIZATION; PARAMETER ESTIMATION; PROBABILITY; PROTEINS;

CELLULAR PROCESSES; LIGANDS; MEMBRANE RECEPTORS; PHOTOISOMERIZATION;

NEUROLOGY;

ADENYLATE CYCLASE; CALCIUM; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; MEMBRANE RECEPTOR; RHODOPSIN; TRANSDUCIN; ACETOPHENONE; ACETOPHENONE DERIVATIVE; CINEOLE; CYCLOHEXANOL DERIVATIVE; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; LIGAND; TERPENE;

CYTOLOGY;

ANIMAL CELL; ARTICLE; CALCIUM CURRENT; CONCENTRATION RESPONSE; CONTROLLED STUDY; EXTRACELLULAR CALCIUM; ISOMERIZATION; MEMBRANE CURRENT; NONHUMAN; OLFACTORY RECEPTOR; PHOTORECEPTOR; PHOTOTRANSDUCTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ASSAY; RECEPTOR BINDING; RETINA ROD; SIGNAL TRANSDUCTION; SMELLING; ACTION POTENTIAL; ANIMAL; CELL SEPARATION; CYTOLOGY; DOSE RESPONSE; FROG; IN VITRO STUDY; KINETICS; METABOLISM; ODOR; PHOSPHORYLATION; PHYSIOLOGY;

ANIMALIA;

ACETOPHENONES; ACTION POTENTIALS; ADENYLATE CYCLASE; ANIMALS; CALCIUM; CELL SEPARATION; CYCLOHEXANOLS; DOSE-RESPONSE RELATIONSHIP, DRUG; HETEROTRIMERIC GTP-BINDING PROTEINS; KINETICS; LIGANDS; MONOTERPENES; ODORS; OLFACTORY RECEPTOR NEURONS; PHOSPHORYLATION; RANA PIPIENS; RECEPTORS, ODORANT; SIGNAL TRANSDUCTION; SMELL;

EID: 21344463521     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1109886     Document Type: Article

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26. We thank D. A. Baylor, P. A. Fuchs, J. S. Kauer, T. D. Lamb, J. Nathans, R. R. Reed, F. Rieke, D. T. Yue, and members of the Yau laboratory, especially J. Bradley and C.-Y. Su, for critique and discussions, V. Kefalov for help in initial experiments, and D. Chaudhuri for help in computations using MatLab. V.B. also thanks D. McClellen for instruction in scientific writing. This work was supported by Howard Hughes Medical Institute and grants from NIH (DC06904) and the Human Frontier Science Program.