Effect of transforming growth factor-β1 on bone regeneration in critical-sized bone defects after irradiation of host tissues

American Journal of Veterinary Research

Volumn 66, Issue 6, 2005, Pages 1039-1045

  Ehrhart, Nicole P ^a   Hong, Liu ^b   Morgan, Abby L ^c   Eurell, JoAnn A ^d   Jamison, Russell D ^c  

^a Department of Environmental and Radiological Health Sciences   (United States)

^b UNIVERSITY OF ILLINOIS   (United States)

^c University of Illinois at Urbana Champaign   (United States)

^d UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GELATIN; TRANSFORMING GROWTH FACTOR BETA1;

ANALYSIS OF VARIANCE; ANIMAL TISSUE; ARTICLE; BONE DEFECT; BONE REGENERATION; COBALT THERAPY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; FEMALE; FRACTURE HEALING; LONG BONE; MORPHOMETRICS; NONHUMAN; OSSIFICATION; PREOPERATIVE RADIOTHERAPY; RABBIT; SUSTAINED DRUG RELEASE; ULNA;

ADMINISTRATION, TOPICAL; ANIMALS; BONE REGENERATION; DELAYED-ACTION PREPARATIONS; HISTOLOGICAL TECHNIQUES; HYDROGELS; IMAGE PROCESSING, COMPUTER-ASSISTED; RABBITS; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; ULNA;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 21344461240     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.2005.66.1039     Document Type: Article

References (37)

1. Griffiths HJ, Anderson JR, Thompson RC, et al. Radiographic evaluation of the complications of long bone allografts. Skeletal Radiol 1995;24:283-286.
2. Temple WJ, Temple CL, Arthur K, et al. Prospective cohort study of neoadjuvant treatment in conservative surgery of soft tissue sarcomas. Ann Surg Oncol 1997;4:586-590.
3. Lin PP, Schupak KD, Boland PJ, et al. Pathologic femoral fracture after periosteal excision and radiation for the treatment of soft tissue sarcoma. Cancer 1998;82:2356-2365.
4. Yasko AW, Johnson ME. Recent advances in bone sarcomas. Cancer Treat Res 1997;90:127-147.
5. Pelker RR, Friedlaender GE. The Nicolas Andry Award-1995. Fracture healing. Radiation induced alterations. Clin Orthop Relat Res 1997;341:267-282.
6. Arnold M, Kummermehr J, Trott KR. Radiation-induced impairment of osseous healing: quantitative studies using a standard drilling defect in rat femur. Radiat Res 1995;143:77-84.
7. Arnold M, Stas F, Kummermehr J, et al. Radiation-induced impairment of bone healing in the rat femur: effects of radiation dose, sequence and interval between surgery and irradiation. Radiother Oncol 1998;48:259-265.
8. Brown RK, Pelker RR, Friedlaender GE, et al. Postfracture irradiation effects on the biomechanical and histologic parameters of fracture healing. J Orthop Res 1991;9:876-882.
9. Emery SE, Brazinski MS, Koka A, et al. The biological and biomechanical effects of irradiation on anterior spinal bone grafts in a canine model. J Bone Joint Surg Am 1994;76:540-548.
10. Mahajan A. The contemporary role of the use of radiation therapy in the management of sarcoma. Surg Oncol Clin N Am 2000;9:503-524.
11. Markbreiter LA, Pelker RR, Friedlaender GE, et al. The effect of radiation on the fracture repair process. A biomechanical evaluation of a closed fracture in a rat model. J Orthop Res 1989;7:178-183.
12. Pelker RR, Friedlaender GE, Panjabi MM, et al. Radiation-induced alterations of fracture healing biomechanics. J Orthop Res 1984;2:90-96.
13. Widmann RF, Pelker RR, Friedlaender GE, et al. Effects of prefracture irradiation on the biomechanical parameters of fracture healing. J Orthop Res 1993;11:422-428.
14. Mankin HJ, Gebhardt MC, Jennings LC, et al. Long-term results of allograft replacement in the management of bone tumors. Clin Orthop Relat Res 1996;324:86-97.
15. Dudziak ME, Saadeh PB, Mehrara BJ, et al. The effects of ionizing radiation on osteoblast-like cells in vitro. Plast Reconstr Surg 2000;106:1049-1061.
16. Saadeh PB, Mehrara BJ, Stembrech DS, et al. Transforming growth factor-beta1 modulates the expression of vascular endothelial growth factor by osteoblasts. Am J Physiol 1999;277:C628-C637.
17. Yamamoto M, Takahashi Y, Tabata Y. Controlled release by biodegradable hydrogels enhances the ectopic bone formation of bone morphogenetic protein. Biomaterials 2003;24:4375-4383.
18. Sykaras N, Opperman LA. Bone morphogenetic proteins (BMPs): how do they function and what can they offer the clinician? J Oral Sci 2003;45:57-73.
19. Sumner DR, Turner TM, Purchio AF, et al. Enhancement of bone ingrowth by transforming growth factor-beta. J Bone Joint Surg Am 1995;77:1135-1147.
20. Brekke JH, Toth JM. Principles of tissue engineering applied to programmable osteogenesis. J Biomed Mater Res 1998;43:380-398.
21. Marie P, Debiais F, Cohen-Solal M, et al. New factors controlling bone remodeling. Joint Bone Spine 2000;67:150-156.
22. Millis DL. Bone- and non-bone-derived growth factors and effects on bone healing. Vet Clin North Am Small Anim Pract 1999;29:1221-1246.
23. Zellin G, Beck S, Hardwick R, et al. Opposite effects of recombinant human transforming growth factor-beta1 on bone regeneration in vivo: effects of exclusion of periosteal cells by microporous membrane. Bone 1998;22:613-620.
24. Hong L, Tabata Y, Yamamoto M, et al. Comparison of bone regeneration in a rabbit skull defect by recombinant human BMP-2 incorporated in biodegradable hydrogel and in solution. J Biomater Sci Polym Ed 1998;9:1001-1014.
25. Hong L, Miyamoto S, Yamada K, et al. Enhanced formation of fibrosis in a rabbit aneurysm by gelatin hydrogel incorporating basic fibroblast growth factor. Neurosurgery 2001;49:954-961.
26. Hong L, Miyamoto S, Hashimoto N, et al. Synergistic effect of gelatin microspheres incorporating TGF-beta1 and a physical barrier for fibrous tissue infiltration on skull bone formation.J Biomater Sci Polym Ed 2000;11:1357-1369.
27. Tabata Y, Hong L, Miyamoto S, et al. Bone formation at a rabbit skull defect by autologous bone marrow cells combined with gelatin microspheres containing TGF-beta1. J Biomater Sci Polym Ed 2000;11:891-901.
28. Yamamoto M, Tabata Y, Hong L, et al. Bone regeneration by transforming growth factor beta1 released from a biodegradable hydrogel. J Control Release 2000;64:133-142.
29. Hall EJ, Brenner DJ. The dose-rate effect revisited: radiobiological considerations of importance in radiotherapy. Int J Radiat Oncol Biol Phys 1991;21:1403-1414.
30. Hall EJ. Weiss lecture. The dose-rate factor in radiation biology. Int J Radiat Biol 1991;59:595-610.
31. Schuck A, Ahrens S, Paulussen M, et al. Local therapy in localized Ewing tumors: results of 1058 patients treated in the CESS 81, CESS 86, and EICESS 92 trials. Int J Radiat Oncol Biol Phys 2003;55:168-177.
32. Lind M, Overgaard S, Nguyen T, et al. Transforming growth factor-beta stimulates bone ongrowth. Hydroxyapatite-coated implants studied in dogs. Acta Orthop Scand 1996;67:611-616.
33. McCaffrey TA, Falcone DJ, Brayton CF, et al. Transforming growth factor-beta activity is potentiated by heparin via dissociation of the transforming growth factor-beta/alpha 2-macroglobulin inactive complex. J Cell Biol 1989;109:441-448.
34. McCaffrey TA, Falcone DJ, Vicente D, et al. protection of transforming growth factor-beta 1 activity by heparin and fucoidan. J Cell Physiol 1994;159:51-59.
35. Paralkar VM, Vukicevic S, Reddi AH. Transforming growth factor beta type 1 binds to collagen IV of basement membrane matrix: implications for development. Dev Biol 1991;143:303-308.
36. Zekom D. Intravascular retention, dispersal, excretion and break-down of gelatin plasma substitutes. Bibl Haematol 1969;33:131-140.
37. Heene DL, Zekorn D, Lasch HG. Gelatine plasma volume expanders: chemistry, biological activities and clinical experiences. Bibl Haematol 1968;29:907-913.