Radiation-induced impairment of bone healing in the rat femur: Effects of radiation dose, sequence and interval between surgery and irradiation

Radiotherapy and Oncology

Volumn 48, Issue 3, 1998, Pages 259-265

  Arnold, Michael ^a   Stas, Paul ^a   Kummermehr, Johann ^a   Schultz Hector, Susanne ^a   Trott, Klaus Ruediger ^b  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

Experimental bone defect; Osseous healing; Postoperative irradiation; Preoperative irradiation; Rat; X Rays

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DEFECT; CELL REGENERATION; CONTROLLED STUDY; FEMALE; FRACTURE HEALING; HETEROTOPIC OSSIFICATION; NONHUMAN; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; RADIATION DOSE; RADIATION INJURY; RADIOBIOLOGY; RAT; TOTAL HIP PROSTHESIS; WOUND HEALING IMPAIRMENT; X RAY;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; FEMUR; RADIATION DOSAGE; RATS; RATS, WISTAR; TIME FACTORS; WOUND HEALING;

EID: 0031731973     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-8140(98)00039-5     Document Type: Article

References (25)

1. Archer, R.R., Greenwell, E.J., Ware, T. and Weeks, P.M. Irradiation effect on wound healing in rats. Radiat. Res. 41: 104-112, 1979.
2. Arnold, M., Kummermehr, J. and Trott, K.R. Radiation-induced impairment of osseous healing: quantitative studies using a standard drilling defect in rat femur. Radiat. Res. 143: 77-84, 1995.
3. Blythe, J.G., Buchsbaum, H.J. and Allen, T.J. The effect of delaying radiation on wound healing. Gynecol. Oncol. 3: 210-214, 1975.
4. Cutright, D.E. and Brady, L.M. Long term effects of radiation on the vascularity of rat bone - quantitative measurements with a new technique. Radiat. Res. 48: 402-408, 1971.
5. Datta, R. Quantitative determination of tolerance doses for pre-operative and post-operative radiotherapy of bone. Med. Phys. 10: 243-245, 1983.
6. Eilber, F.R., Morton, D.L., Eckardt, J., Grant, T. and Weisenburger, T. Limb salvage for skeletal and soft tissue sarcomas. Multidisciplinary pre-operative therapy. Cancer 53: 2579-2584, 1984.
7. Field, S.B. and Hornsey, S. Slow repair after X-rays and fast neutrons. Br. J. Radiol. 50: 500-601, 1977.
8. Finston, R.A., Woodard, H.Q. and Loughlin, J.S. Effects of external irradiation on mineral metabolism in the bones of adult dogs. Clin. Orthop. Rel. Res. 46: 183-201, 1966.
9. Gorodetsky, R., McBride, W.H. and Withers, H.R. Assay of radiation effects in mouse skin as expressed in wound healing. Radiat. Res. 116: 135-144, 1988.
10. Hayashi, S. and Suit, H.D. Effect of fractionation of radiation dose on callus formation at site of fracture. Radiology 101: 181-186, 1971.
11. Hopewell, J.W. and Young, C.M.A. Changes in the microcirculation of normal tissues after irradiation. Int. J. Radiat. Oncol. Biol. Phys. 4: 53-58, 1978.
12. Hunt, T.K. and Pai, M.P. The effect of varying ambient oxygen tensions on wound metabolism and collagen synthesis. Surg. Gynecol. Obstet. 135: 561-567, 1972.
13. Jacobsen, M., Jönsson, A., Albrektsson, T. and Turesson, I. Dose response for bone regeneration after single doses of Co-60 irradiation. Int. J. Radiat. Oncol. Biol. Phys. 11: 1963-1969, 1985.
14. Lawrence, W., Nickson, J.J. and Warshaw, L.M. Roentgen rays and wound healing. An experimental study. Surgery 33: 376-384, 1953.
15. Patterson, T.J.S., Berry, R.J. and Wiernik, G. The effect of X-irradiation on the survival of skin flaps of the pig. Br. J. Plast. Surg. 25: 17-19, 1972.
16. Reinhold, H.S. and Buisman, G.H. Repair of radiation damage to capillary endothelium. Br. J. Radiol. 48: 727-731, 1975.
17. Rodemann, H.S. and Bamberg, M. Cellular basis of radiation-induced fibrosis. Radiother. Oncol. 35: 83-90, 1995.
18. Schlegel, D., Hilfrich, J., Klemm, H. and Schreckenberger, H. Knochenregeneration im Tierversuch nach Strahlenbelastung. Electromedica 1: 26-28, 1972.
19. Seegenschmiedt, M.H., Martus, P., Goldmann, A.R., Wolfel, R., Keilholz, L. and Sauer, R. Pre-operative versus post-operative radiotherapy for prevention of heterotopic ossification (HO): first results of a randomized trial in high-risk patients. Int. J. Radiat. Oncol. Biol. Phys. 30: 63-73, 1994.
20. Stewart, F.A. and van der Kogel, A.J. Retreatment tolerance of normal tissues. Semin. Radiat. Oncol. 4: 103-111, 1994.
21. Suit, H.D. The George Edelstyn Memorial Lecture: radiation in the management of malignant soft tissue tumours. Clin. Oncol. 1: 5-10, 1989.
22. Tonna, E.A. and Cronkite, E.P. Changes in the skeletal cell proliferative response to trauma concomitant with ageing. J. Bone Joint Surg. 44-A: 1157-1168, 1962.
23. Trott, K.R. Chronic damage after radiation therapy: challenge to radiation biology. Int. J. Radiat. Oncol. Biol. Phys. 10: 907-913, 1984.
24. van den Brenk, H.A.S., Sharpingtom, C., Orton, C. and Stone, M. Effects of X-radiation on growth and function of the repair blastema (granulation tissue) II. Measurement of angiogenesis in the Selye pouch in the rat. Int. J. Radiat. Biol. 25: 277-289, 1975.
25. Weissman, R.A., Blumberg, A.L., Broussau, D.A., Hurford, W.E. and Silverman, D.G. Fluorimetric assessment of skin flap viability in the rat: effect of radiation therapy. Otolaryngol. Head Neck Surg. 91: 151-155, 1983.