TNF-α promoter gene polymorphism in patients with myelodysplastic syndrome

Acta Haematologica

Volumn 113, Issue 4, 2005, Pages 262-264

  Kádár, Katalin ^a,d   Demeter, Judit ^a   Andrikovics, Hajnalka ^c   Tordai, Attila ^c   Kovács, Margit ^b   Füst, George ^b   Karádi, István ^b   Várkonyi, Judit ^b  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

^c NATIONAL MEDICAL CENTER   (Hungary)

^d NONE   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; GENE FREQUENCY; GENOTYPE; HUMAN; MALE; MYELODYSPLASTIC SYNDROME; MYELOPROLIFERATIVE DISORDER; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; REFRACTORY ANEMIA WITH EXCESS BLASTS; REFRACTORY ANEMIA WITH EXCESS BLASTS IN TRANSFORMATION; REFRACTORY ANEMIA WITH RINGED SIDEROBLASTS; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

ADULT; AGED; AGED, 80 AND OVER; FEMALE; HUMANS; MALE; MIDDLE AGED; MYELODYSPLASTIC SYNDROMES; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; PROMOTER REGIONS (GENETICS); TUMOR NECROSIS FACTOR-ALPHA;

EID: 21344437010     PISSN: 00015792     EISSN: None     Source Type: Journal    
DOI: 10.1159/000084681     Document Type: Article

References (13)

1. Parker JE, Mufti GJ: Ineffective erythropoiesis and apoptosis in myelodysplastic syndromes. Br J Haematol 1998;101:220-230.
2. Raza A, Mundle S, Shetty V, Alvi S, Chopra H, Span L, Parcharidou A, Dar S, Venugopal P, Borok R, Gezer S, Showel J, Loew J, Robin E, Rifkin S, Alston D, Hernandez B, Shah R, Kaizer H, Gregory S: Novel insights into the biology of myelodysplastic syndromes: Excessive apoptosis and the role of cytokines. Int J Hematol 1996;63:265-278.
3. Verhoef GE, De Schouwer P, Ceuppens JL, Van Damme J, Goossens W, Boogaerts MA: Measurement of serum cytokine levels in patients with myelodysplastic syndromes. Leukemia 1992;6:1268-1272.
4. Musto P, Matera R, Minervini MM, Checchia de Ambrosio C, Bodenizza C, Falcone A, Carotenuto M: Low serum levels of tumor necrosis factor and interleukin-1 beta in myelodysplastic syndromes responsive to recombinant erythropoietin. Haematologica 1994;79:265-268.
5. Gersuk GM, Beckham C, Loken MR, Kiener P, Anderson JE, Farrand A, Troutt AB, Ledbetter JA, Deeg HJ: A role for tumour necrosis factor-alpha, Fas and Fas-ligand in marrow failure associated with myelodysplastic syndrome. Br J Haematol 1998;103:176-188.
6. Hajeer AH, Hutchinson IV: Influence of TNF-alpha gene polymorphisms on TNF-alpha production and disease. Hum Immunol 2001;62:1191-1199.
7. Miller SA, Dykes DD, Polesky HF: A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988;16:1215.
8. Day CP, Grove J, Daly AK, Stewart MW, Avery PJ, Walker M: Tumour necrosis factor-alpha gene promoter polymorphism and decreased insulin resistance. Diabetologia 1998;41:430-434.
9. Vatay Á, Yang Y, Chung EK, Zhou B, Blanchong CA, Kovács M, Karádi I, Füst G, Romics L, Varga L, Yu CY, Szalai Cs: Relationship between complement components C4A and C4B diversities and two TNFA promoter polymorphisms in two healthy Caucasian populations. Hum Immunol 2003;64:543-552.
10. Demeter J, Messer G, Rajczy K, Patscht K, Pénzes M, Kenéz A, Karádi I: Polymorphism of the TNF-alpha, the IL-6 promoter and the IL-1 receptor antagonist at the DNA level in a Hungarian population and relation to infectious, autoimmune and malignant diseases. Magy Belorv Arch 2000;53:185-193.
11. Louis E, Franchimont D, Piron A, Gevaert Y, Schaaf-Lafontaine N, Roland S, Mahieu P, Malaise M, De Groote D, Louis R, Belaiche J: Tumour necrosis factor (TNF) gene polymorphism influences TNF-alpha production in lipopolysaccharide (LPS)-stimulated whole blood cell culture in healthy humans. Clin Exp Immunol 1998;113:401-406.
12. Huizinga TW, Westendorp RG, Bollen EL, Keijsers V, Brinkman BM, Langermans JA, Breedveld FC, Verweij CL, van de Gaer L, Dams L, Crusius JB, Garcia-Gonzalez A, van Oosten BW, Polman CH, Peria AS: TNF-alpha promoter polymorphisms, production and susceptibility to multiple sclerosis in different groups of patients. J Neuroimmunol 1997;72:149-153.
13. Pociot F, D'Alfonso S, Compasso S, Scorza R, Richiardi PM: Functional analysis of a new polymorphism in the human TNF alpha gene promoter. Scand J Immunol 1995;42:501-508.