Identification of compounds that inhibit growth of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine-resistant cancer cells

Molecular Cancer Therapeutics

Volumn 4, Issue 6, 2005, Pages 1026-1030

  Bachman, Kurtis E ^a,c   Sager, Jason ^a   Cheong, Ian ^a   Catto, Marco ^b   Bardelli, Alberto ^a   Park, Ben Ho ^a   Vogelstein, Bert ^a   Carotti, Angelo ^b   Kinzler, Kenneth W ^a   Lengauer, Christoph ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b UNIVERSITY OF BARI   (Italy)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; ANTINEOPLASTIC AGENT; KLB 1; KLB 2; KLB 3; KLB 4; KLB 5; KLB 6; KLB 7; KLB 8; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CANCER PREVENTION; CANCER RESISTANCE; COLORECTAL CANCER; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG SELECTIVITY; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; GASTROINTESTINAL TUMOR; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG EVALUATION, PRECLINICAL; DRUG RESISTANCE, NEOPLASM; HUMANS; IMIDAZOLES; INDENES; INHIBITORY CONCENTRATION 50; PYRIDAZINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 21344433487     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-05-0038     Document Type: Article

References (16)

1. Schut HA, Snyderwine EG. DNA adducts of heterocyclic amine food mutagens: implications for mutagenesis and carcinogenesis. Carcinogenesis 1999;20:353-68.
2. Thorgeirsson UP, Snyderwine EG, Gomez DE, Adamson RH. Dietary heterocyclic amines as potential human carcinogens: experimental data from nonhuman primates. In Vivo 1996;10:145-52.
3. Gooderham NJ, Zhu H, Lauber S, Boyce A, Creton S. Molecular and genetic toxicology of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Mutat Res 2002;506-7:91-9.
4. Felton JS, Knize MG, Bennett LM, Malfatti MA, Colvin ME, Kulp KS. Impact of environmental exposures on the mutagenicity/carcinogenicity of heterocyclic amines. Toxicology 2004;198:135-45.
5. Pfau W, Martin FL, Cole KJ, et al. Heterocyclic aromatic amines induce DNA strand breaks and cell transformation. Carcinogenesis 1999; 20:545-51.
6. el-Bayoumy K, Chae YH, Upadhyaya P, et al. Comparative tumorigenicity of benzo[a]pyrene, 1-nitropyrene and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine administered by gavage to female CD rats. Carcinogenesis 1995;16:431-4.
7. Ito N, Hasegawa R, Sano M, et al. A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Carcinogenesis 1991;12:1503-6.
8. Shirai T, Sano M, Tamano S, et al. The prostate: a target for carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) derived from cooked foods. Cancer Res 1997;57:195-8.
9. Hasegawa R, Sano M, Tamano S, et al. Dose-dependence of 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP) carcinogenicity in rats. Carcinogenesis 1993;14:2553-7.
10. Ghoshal A, Preisegger KH, Takayama S, Thorgeirsson SS, Snyderwine EG. Induction of mammary tumors in female Sprague-Dawley rats by the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and effect of dietary fat. Carcinogenesis 1994; 15:2429-33.
11. Koi M, Umar A, Chauhan DP, et al. Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N′-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation. Cancer Res 1994;54:4308-12.
12. Bardelli A, Cahill DP, Lederer G, et al. Carcinogen-specific induction of genetic instability. Proc Natl Acad Sci U S A 2001;98: 5770-5.
13. Altomare C, Campagna F, Carta V, et al. Synthesis, benzodiazepine receptor affinity and anticonvulsant activity of 5-H-indeno[1,2-c]pyridazine derivatives. Farmaco 1994;49:313-23.
14. Kneubuhler S, Carta V, Altomare C, Carotti A, Testa B. Synthesis and monoamine oxidase inhibitory activity of 3-substituted 5H-indeno[1,2-c] pyridazines. Helv Chim Acta 1993;76:1956-63.
15. Kneubuhler S, Thull U, Altomare C, et al. Inhibition of monoamine oxidase-B by 5H-indeno[1,2-c]pyridazines: biological activities, quantitative structure-activity relationships (QSARs) and 3D-QSARs. J Med Chem 1995;38:3874-83.
16. Carotti A, Carta V, Campagna F, Altomare C, Casini G. An efficient route to biologically active 5H-indeno[1,2-c]pyridazine-5-ones. Farmaco 1993;48:137-41.