First synthesis and evaluation of the inhibitory effects of Aza analogues of TSAO on HIV-1 replication

Journal of Medicinal Chemistry

Volumn 48, Issue 13, 2005, Pages 4276-4284

  Van Nhien, Albert Nguyen ^a   Tomassi, Cyrille ^a   Len, Christophe ^a   Marco Contelles, José Luis ^b   Balzarini, Jan ^c   Pannecouque, Christophe ^c   De Clercq, Erik ^c   Postel, Denis ^a  

^a UNIVERSITÉ DE PICARDIE JULES VERNE   (France)

^b INSTITUTO DE QUÍMICA ORGÁNICA GENERAL   (Spain)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

2',5' BIS O (TERT BUTYLDIMETHYLSILYL) BETA DEXTRO RIBOFURANOSYL 3' SPIRO 5'' (4'' AMINO 1'',2'' OXATHIOLE 2'',2'' DIOXIDE) THYMINE; [1 [2',5' BIS O TERT BUTYLDIMETHYLSILYL BETA DEXTRO RIBOFURANOSYL] 3 N ETHYLTHYMINE] 3' SPIRO 3'' (2'' H 4'' AMINO 2'',3'' DIHYDRO 1'',1'' DIOXO ISOTHIAZOLE; [1 [2',5' BIS O TERT BUTYLDIMETHYLSILYL BETA DEXTRO RIBOFURANOSYL] 3 N METHYLTHYMINE ] 3' SPIRO 3'' (4'' AMINO 2'',3'' DIHYDRO 2'' N METHYL 1'',1'' DIOXO ISOTHIAZOLE; [1 [2',5' BIS O TERT BUTYLDIMETHYLSILYL BETA DEXTRO RIBOFURANOSYL] 3 N METHYLTHYMINE] 3' SPIRO 3'' (2'' H 4'' AMINO 2'',3'' DIHYDRO 1'',1'' DIOXO ISOTHIAZOLE; [1 [2',5' BIS O TERT BUTYLDIMETHYLSILYL BETA DEXTRO RIBOFURANOSYL] 3 N TERT BUTOXYCARBONYLTHYMINE] 3' SPIRO 3'' (2'' H 4'' AMINO 2'',3'' DIHYDRO 1'',1'' DIOXO ISOTHIAZOLE; [1 [2',5' BIS O TERT BUTYLDIMETHYLSILYL BETA DEXTRO RIBOFURANOSYL] 3 N TERT BUTOXYCARBONYLTHYMINE] 3' SPIRO 3'' (4'' AMINO 2'',3'' DIHYDRO 2'' N METHYL 1'',1'' DIOXO ISOTHIAZOLE; [1 [2',5' BIS O TERT BUTYLDIMETHYLSILYL BETA DEXTRO RIBOFURANOSYL] THYMINE] 3' SPIRO 3'' (2'' H 4'' AMINO 2'',3'' DIHYDRO 1'',1'' DIOXO ISOTHIAZOLE; [1 [2',5' BIS O TERT BUTYLDIMETHYLSILYL BETA DEXTRO RIBOFURANOSYL] THYMINE] 3' SPIRO 3'' (4'' AMINO 2'',3'' DIHYDRO 2'' N METHYL 1'',1'' DIOXO ISOTHIAZOLE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; HETEROCYCLIC COMPOUND; ISOTHIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CELL CULTURE; CELL LINE; DEBENZYLATION; DRUG EFFECT; DRUG INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; SILYLATION; SUBSTITUTION REACTION; T LYMPHOCYTE; VIRUS REPLICATION;

AZA COMPOUNDS; CELL LINE; HIV-1; HIV-2; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; REVERSE TRANSCRIPTASE INHIBITORS; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP; THYMIDINE; VIRUS REPLICATION;

EID: 21244499836     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050091g     Document Type: Article

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