Apparent charge of binding site in ion-translocating enzymes: Kinetic impact

European Biophysics Journal

Volumn 34, Issue 4, 2005, Pages 353-357

  Gradmann, Dietrich ^a   Boyd, Carl M ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Current voltage relationship; Electro enzymes; Enzyme kinetics; Voltage clamp; Voltage sensitivity

Indexed keywords

ARTICLE; BINDING SITE; CATALYSIS; ELECTRIC ACTIVITY; ELECTRIC CURRENT; ELECTRIC FIELD; ELECTRIC POTENTIAL; ENZYME LOCALIZATION; KINETICS; LIPID MEMBRANE; MICHAELIS CONSTANT; PROTEIN INTERACTION; QUALITATIVE ANALYSIS; SENSITIVITY ANALYSIS; STEADY STATE;

BINDING SITES; BIOLOGICAL TRANSPORT; BIOPHYSICS; ENZYMES; ION CHANNELS; ION TRANSPORT; IONS; KINETICS; MODELS, CHEMICAL; PATCH-CLAMP TECHNIQUES; SUBSTRATE SPECIFICITY;

EID: 21244499347     PISSN: 01757571     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00249-004-0457-5     Document Type: Article

References (12)

1. Allen GJ, Sanders D, Gradmann D (1998) Calcium-potassium selectivity: kinetic analysis of current-voltage relationships of the open, slowly activating channel in the vacuolar membrane of guard-cells of Vicia faba. Planta 204:528-541
2. + channel. Nature 414:73-76
3. Boyd J, Gradmann D, Boyd CM (2003) Transinhibition and voltage-gating in a fungal nitrate transporter. J Membr Biol 195:1-12
4. Eisenberg RS (1990) Channels as enzymes. J Membr Biol 115:1-12
5. Gradmann D, Boyd CM (1999) Electrophysiology of the marine diatom Coscinodiscus wailesii IV: types of non-linear current-voltage-time relationships recorded with single saw-tooth voltage-clamp. Eur Biophys J 28:591-599
6. Gradmann D, Boyd CM (2000) Three types of membrane excitations in the marine diatom Coscinodiscus wailesii. J Membr Biol 175:149-160
7. Gradmann D, Boyd CM (2004) Current-voltage-time records of ion translocating enzymes. Eur Biophys J 33:396-411
8. Hansen U-P, Gradmann D, Sanders D, Slayman CL (1981) Interpretation of current-voltage relationships for active ion transport systems. I. Steady-state reaction-kinetic analysis of Class-I mechanisms. J Membr Biol 63:165-190
9. + channel. Nature 423:42-48
10. Läuger P (1980) Kinetic properties of ion carriers and channels. J Membr Biol 57:163-178
11. Läuger P (1995) Conformational transitions of ionic channels. In: Sakmann B, Neher E (eds) Single-channel recording, 2nd edn. Plenum, New York, pp 651-662
12. Morais-Cabral J, Zhou Y, MacKinnon R (2001) Energetic optimization of ion conduction rate by the K+ selectivity filter. Nature 414:37-42