Translational research in autoimmunity: Aims of therapy in vasculitis

Rheumatology

Volumn 44, Issue 5, 2005, Pages 573-576

  Watts, Richard ^e   Harper, L ^c   Jayne, D ^d   Levy, J ^b   Pusey, C ^b   Savage, C ^c   Scott, D G I ^a   Williams, J ^c  

^a NORFOLK AND NORWICH UNIVERSITY HOSPITAL   (United Kingdom)

^b IMPERIAL COLLEGE HEALTHCARE NHS TRUST   (United Kingdom)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^d ADDENBROOKE S HOSPITAL   (United Kingdom)

^e UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; CYCLOPHOSPHAMIDE; ENZYME ANTIBODY; ETANERCEPT; INFLIXIMAB; METHOTREXATE; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; MYELOPEROXIDASE; PREDNISOLONE; RITUXIMAB; THYMOCYTE ANTIBODY; IMMUNOSUPPRESSIVE AGENT; NEUTROPHIL CYTOPLASMIC ANTIBODY;

ANCA ASSOCIATED VASCULITIS; AUTOIMMUNITY; CHURG STRAUSS SYNDROME; CLINICAL TRIAL; DRUG FATALITY; EDITORIAL; HEMORRHAGIC CYSTITIS; HUMAN; INFECTION; KIDNEY DISEASE; KIDNEY FAILURE; LEUKOPENIA; MEDICAL RESEARCH; NONHUMAN; PLASMAPHERESIS; POLYARTERITIS NODOSA; PRIORITY JOURNAL; RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS; RECURRENCE RISK; SYSTEMIC VASCULITIS; WEGENER GRANULOMATOSIS; AUTOIMMUNE DISEASE; IMMUNOLOGY; MASS COMMUNICATION; VASCULITIS;

ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; AUTOIMMUNE DISEASES; DIFFUSION OF INNOVATION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; VASCULITIS;

EID: 21244492356     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/keh609     Document Type: Editorial

References (30)

1. Watts RA, Scott DGI, Pusey CD, Lockwood CM. Vasculitis - aims of therapy. Rheumatology 2000;39:229-37.
2. Walton EW. Giant cell granuloma of the respiratory tract. Br Med J 1958;2:265-70.
3. Gordon C, Luqmani R, Adu D. Relapses in patients with a systemic vasculitis. Q J Med 1993;86:779-89.
4. de Groot K, Rasmussen N, Cohen-Tervaert JW, Jayne DRW for EUVAS. Randomised trial of cyclophosphamide versus methotrexate for induction of remission in non-renal ANCA-associated vasculitis. Arthritis Rheum 2003;48(Suppl):S660.
5. Jayne D, Rasmussen N, Andrassy K et al. on behalf European Vasculitis Study Group. A randomized trial of maintenance therapy for vasculitis associated with antineutrophil cytoplasmic autoantibodies. N Engl J Med 2003;349:36-44.
6. Gaskin G, Jayne DR, European Vasculitis Study Group. Adjunctive plasma exchange is superior to methylprednisolone in acute renal failure due to ANCA-associated glomerulonephritis. J Am Soc Nephrol 2002;13:2A-3A.
7. de Groot K, Adu D, Savage COS. The value of pulse cyclophosphamide in ANCA-associated vasculitis: Meta-analysis and critical review. Nephrol Dialysis Transplant 2001;16:2018-27.
8. Gayraud M, Guillevin L, le Toumelin P, et al. French Vasculitis Study Group. Long-term followup of polyarteritis nodosa, microscopic polyangiitis, and Churg-Strauss syndrome: Analysis of four prospective trials including 278 patients. Arthritis Rheum 2001; 44:666-75.
9. Edwards JCW, Cambridge G. Prospects for B-cell-targeted therapy in autoimmune disease. Rheumatology 2005;44:151-6.
10. Edwards JC, Szczepanski L, Szechinski J et al. Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis. N Engl J Med 2004;350:2572-81.
11. Wegener's Granulomatosis Etanercept Trial (WGET) Research Group. Etanercept plus standard therapy for Wegener's granulomatosis. N Engl. J Med 2005;352:351-61.
12. Booth A, Harper L, Hammad T et al. Prospective study of TNF-alpha blockade with infliximab in anti-neutrophil cytoplasmic antibody-associated systemic vasculitis. J Am Soc Nephrol 2004;15:717-21.
13. Schmitt WH, Hagen EC, Neumann I, Nowack R, Flores-Suarez LF, van der Woude FJ; European Vasculitis Study Group. Treatment of refractory Wegener's granulomatosis with antithymocyte globulin (ATG): An open study in 15 patients. Kidney Int 2004;65:1440-8.
14. Williams JM, Kamesh L, Savage CO. Translating basic science into patient therapy for ANCA-associated small vessel vasculitis. Clin Sci 2005;108:101-42.
15. Holland M, Hewins P, Goodall M, Adu D, Jefferis R, Savage CO. Anti-neutrophil cytoplasm antibody IgG subclasses in Wegener's granulomatosis: A possible pathogenic role for the IgG4 subclass. Clin Exp Immunol 2004;138:183-92.
16. van der Geld YM, Stegeman CA, Kallenberg CG. B cell epitope specificity in ANCA-associated vasculitis: Does it matter? Clin Exp Immunol 2004;137:451-9.
17. Tse W, Nash G, Hewins P, Savage C, Adu D. ANCA-induced neutrophil F-actin polymerisation: Implications for microvascular inflammation. Kidney Int 2005;67:130-9.
18. Van Rossum AP, Rarok AA, Huitema MG, Fassina G, Limburg PC, Kallenberg CG. Constitutive membrane expression of proteinase 3 (PR3) and neutrophil activation by anti-PR3 antibodies. J Leukoc Biol 2004;76:1162-70.
19. Calderwood JW, Williams JM, Morgan MD, Nash GB, Savage CO. ANCA induces beta2 integrin and CXC chemokine-dependent neutrophil-endothelial cell interactions that mimic those of highly cytokine-activated endothelium. J Leukoc Biol 2005;77:33-43.
20. Harper L, Cockwell P, Adu D, Savage C. Neutrophil priming and apoptosis in ANCA-associated vasculitis. Kidney Int 2001;59: 1729-38.
21. Donald KJ, Edwards RL, McEvoy JDS. An ultrastructural study of the pathogenesis of tissue injury in limited Wegener's granulomatosis. Pathology 1976;8:161-9.
22. Rastaldi M, Ferrario F, Crippa A et al. Glomerular monocyte-macrophage features in ANCA-positive renal vasculitis and cryoglobulinemic nephritis. J Am Soc Nephrol 2000;11:2036-43.
23. Harper L, Ren Y, Savill J, Adu D, Savage C. Dysregulated neutrophil apoptosis in systemic vasculitis. Am J Pathol 2000;157: 211-20.
24. Usher LR, Lawson RA, Geary I et al. Induction of neutrophil apoptosis by the Pseudomonas aeruginosa exotoxin pyocyanin: A potential mechanism of persistent infection. J Immunol 2002;168: 1861-8.
25. Brouwer E, Huitema MG, Klok PA, Cohen Tervaert JW, Weening JJ, Kallenberg CGM. Anti-myeloperoxidase associated proliferative glomerulonephritis: An animal model. J Exp Med 1993; 177:905-14.
26. Yang JJ, Jennette JC, Falk RJ. Immune complex glomerulonephritis is induced in rats immunised with heterologous myeloperoxidase. Clin Exp Immunol 1994;97:466-73.
27. Heeringa P, Brouwer E, Kolk PA et al. Autoantibodies to myeloperoxidase aggravate mild anti-glomerular-basement-membrane-mediated glomerular injury in the rat. Am J Pathol 1996;149:1695-706.
28. Xiao H, Heeringa P, Hu P et al. Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice. J Clin Invest 2002;110:955-63.
29. Lucy CL, Smith J, Cook HT, Haskard DO, Pusey CD. Immunisation with MPO directly induces small vessel vasculitis with pauci-immune focal segmental glomerulonephritis and alveolar haemorrhage in WKY rats. J Am Soc Nephrol 2002; 13:170A.
30. Little MA, Smyth CL, Ambrose LR, Cook T, Pusey CD. In vivo effects of the induction of ANCA on leukocyte adhesion and transmigration as assessed by intravital microscopy. J Am Soc Nephrol 2004;15:693.