TGF-α, c-erbB-2 expression and neoangiogenesis in vulvar squamous cell carcinoma

Anticancer Research

Volumn 25, Issue 3 A, 2005, Pages 1731-1737

  Hantschmann, Peer ^a   Jeschke, Udo ^b   Friese, Klaus ^b  

^a Kreisklinik Altöting ^*  (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

c erbB 2; Immunohistology; Neoangiogenesis; Prognosis; TGF ; Vulvar carcinoma

Indexed keywords

BLOOD CLOTTING FACTOR 8; EPIDERMAL GROWTH FACTOR RECEPTOR 2; TRANSFORMING GROWTH FACTOR ALPHA;

ADULT; ANGIOGENESIS; BIOPSY; CARCINOGENESIS; CELL DENSITY; CONFERENCE PAPER; CORRELATION ANALYSIS; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOLOGY; MAJOR CLINICAL STUDY; MICROVASCULATURE; NEOANGIOGENESIS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; SQUAMOUS CELL CARCINOMA; VULVA CARCINOMA;

FEMALE; HUMANS; NEOVASCULARIZATION, PATHOLOGIC; PROGNOSIS; RECEPTOR, ERBB-2; TRANSFORMING GROWTH FACTOR ALPHA; VULVAR NEOPLASMS;

EID: 21244485076     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (36)

1. Liotta LA and Stracke ML: Tumor invasion and metastases: biochemical mechanisms. Cancer Treat Res 40: 223-238, 1988.
2. Bouck N, Stellmach V and Hsu SC: How tumors become angiogenic. Adv Cancer Res 69: 135-174, 1996.
3. Hanahan D and Folkman J: Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86: 353-364, 1996.
4. Benjamin LE, Golijanin D, Itin A, Pode D and Keshet E: Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J Clin Invest 103: 159-165, 1999.
5. Asahara T, Bauters C, Zheng LP, Takeshita S, Bunting S, Ferrara N et al: Synergistic effect of vascular endothelial growth factor and basic fibroblast growth factor on angiogenesis in vivo. Circulation 92: II365-II371, 1995.
6. Schreiber AB, Winkler ME and Derynck R: Transforming growth factor-alpha: a more potent angiogenic mediator than epidermal growth factor. Science 232: 1250-1253, 1986.
7. Kumar R and Yarmand-Bagheri R: The role of HER2 in angiogenesis. Semin Oncol 28: 27-32, 2001.
8. Tanigawa N, Amaya H, Matsumura M, Lu C, Kitaoka A, Matsuyama K et al: Tumor angiogenesis and mode of metastasis in patients with colorectal cancer. Cancer Res 57: 1043-1046, 1997.
9. Vermeulen PB, Van den Eynden GG, Huget P, Goovaerts G, Weyler J, Lardon F et al: Prospective study of intratumoral microvessel density, p53 expression and survival in colorectal cancer. Br J Cancer 79: 316-322, 1999.
10. Yamanaka Y, Friess H, Buchler M, Beger HG, Uchida E, Onda M et al: Overexpression of acidic and basic fibroblast growth factors in human pancreatic cancer correlates with advanced tumor stage. Cancer Res 53: 5289-5296, 1993.
11. Kabulski Z and Frankman O: Histologic malignancy grading in invasive squamous cell carcinoma of the vulva. Int J Gynaecol Obstet 16: 233-237, 1978.
12. Wilkinson EJ, Rico MJ and Pierson KK: Microinvasive carcinoma of the vulva. Int J Gynecol Pathol 1: 29-39, 1982.
13. Weidner N: Current pathologic methods for measuring intratumoral microvessel density within breast carcinoma and other solid tumors. Breast Cancer Res Treat 36: 169-180, 1995.
14. Saravanamuthu J, Reid WM, George DS, Crow JC, Rolfe KJ, MacLean AB et al: The role of angiogenesis in vulvar cancer, vulvar intraepithelial neoplasia, and vulvar lichen sclerosus as determined by microvessel density analysis. Gynecol Oncol 89: 251-258, 2003.
15. Koukourakis MI, Manolas C, Minopoulos G, Giatromanolaki A and Sivridis E: Angiogenesis relates to estrogen receptor negativity, c-erbB-2 overexpression and early relapse in node-negative ductal carcinoma of the breast. Int J Surg Pathol 11: 29-34, 2003.
16. Wu X, Xin Y, Yao J, Hasui K, Tsuyama S, Yonezawa S et al: Expression of epithelial growth factor receptor and its two ligands, transforming growth factor-alpha and epithelial growth factor, in normal and neoplastic squamous cells in the vulva: an immunohistochemical study. Med Electron Microsc 34: 179-184, 2001.
17. Konishi I, Ishikawa Y, Wang SY, Wang DP, Koshiyama M, Mandai M et al: Expression of transforming growth factor-alpha in the normal cervix and in benign and malignant lesions of the uterine cervix. Br J Obstet Gynaecol 101: 325-329, 1994.
18. Rusch V, Klimstra D, Venkatraman E, Pisters PW, Langenfeld J and Dmitrovsky E: Overexpression of the epidermal growth factor receptor and its ligand transforming growth factor alpha is frequent in resectable non-small cell lung cancer but does not predict tumor progression. Clin Cancer Res 3: 515-522, 1997.
19. Xynos FP, Klos DJ, Hamilton PD, Schuette V and Fernandez-Pol JA: Expression of transforming growth factor alpha mRNA in benign and malignant tissues derived from gynecologic patients with various proliferative conditions. Anticancer Res 12: 1115-1120, 1992.
20. Li Z, Shimada Y, Uchida S, Maeda M, Kawabe A, Mori A et al: TGF-alpha as well as VEGF, PD-ECGF and bFGF contribute to angiogenesis of esophageal squamous cell carcinoma. Int J Oncol 17: 453-460, 2000.
21. D'Errico A, Barozzi C, Fiorentino M, Carella R, Di Simone M, Ferruzzi L et al: Role and new perspectives of transforming growth factor-alpha (TGF-alpha) in adenocarcinoma of the gastro-oesophageal junction. Br J Cancer 82: 865-870, 2000.
22. Grandis JR, Melhem MF, Gooding WE, Day R , Holst VA, Wagener MM et al: Levels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival. J Natl Cancer Inst 90: 824-832, 1998.
23. Barozzi C, Ravaioli M, D'Errico A, Grazi GL, Poggioli G, Cavrini G et al: Relevance of biologic markers in colorectal carcinoma: a comparative study of a broad panel. Cancer 94: 647-657, 2002.
24. Lee CS, Redshaw A and Boag G: TGF-alpha immunoreactivity in laryngeal carcinoma: lack of prognostic value and correlation to EGF-receptor expression. Aust N Z J Surg 66: 464-468, 1996.
25. Felip E, Del Campo JM, Rubio D, Vidal MT , Colomer R and Bermejo B: Overexpression of c-erbB-2 in epithelial ovarian cancer. Prognostic value and relationship with response to chemotherapy. Cancer 75: 2147-2152, 1995.
26. Slamon DJ, Godolphin W, Jones LA, Holt JA, Wong SG, Keith DE et al: Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science 244: 707-712, 1989.
27. Gordinier ME, Steinhoff MM, Hogan JW, Peipert JF, Gajewski WH, Falkenberry SS et al: S-phase fraction, p53, and HER-2/neu status as predictors of nodal metastasis in early vulvar cancer. Gynecol Oncol 67: 200-202, 1997.
28. Giatromanolaki A, Koukourakis MI, Sivridis E and Fountzilas G: c-erbB-2 oncoprotein is overexpressed in poorly vascularised squamous cell carcinomas of the head and neck, but is not associated with response to cytotoxic therapy or survival. Anticancer Res 20: 997-1004, 2000.
29. Lopez-Guerrero JA, Navarro S, Noguera R, Almenar S, Pellin A, Vazquez C et al: Histological tumor grade correlates with HER2/c-erB-2 status in invasive breast cancer: a comparative analysis between immunohistochemical (CB11 clone and Herceptest), FISH and differential PCR procedures. Arkh Patol 65: 50-55, 2003.
30. Hagedorn HG and Nerlich AG: Microvessel density and endothelial basement membrane composition in laryngeal squamous cell carcinomas. Acta Otolaryngol 120: 891-898, 2000.
31. Obermair A, Kohlberger P, Bancher-Todesca D, Tempfer C, Sliutz G, Leodolter S et al: Influence of microvessel density and vascular permeability factor/vascular endothelial growth factor expression on prognosis in vulvar cancer. Gynecol Oncol 63: 204-209, 1996.
32. Gasinska A, Urbanski K, Adamczyk A, Pudelek J, Lind BK and Brahme A: Prognostic significance of intratumour microvessel density and haemoglobin level in carcinoma of the uterine cervix. Acta Oncol 41: 437-443, 2002.
33. Graflund M, Sorbe B, Hussein A, Bryne M and Karlsson M: The prognostic value of histopathologic grading parameters and microvessel density in patients with early squamous cell carcinoma of the uterine cervix. Int J Gynecol Cancer 12: 32-41, 2002.
34. Lee JS, Kim HS, Jung JJ, Lee MC and Park CS: Angiogenesis, cell proliferation and apoptosis in progression of cervical neoplasia. Anal Quant Cytol Histol 24: 103-113, 2002.
35. Mullerat J, Wong-Te-Fong LF, Davies SE, Winslet MC and Perrett CW: Angiogenesis in anal warts, anal intraepithelial neoplasia and anal squamous cell carcinoma. Colorectal Dis 5: 353-357, 2003.
36. Bamberger ES and Perrett CW: Angiogenesis in benign, premalignant and malignant vulvar lesions. Anticancer Res 22: 3853-3865, 2002.