The effects of hormone therapy, estrogen therapy and tibolone on apoptosis and cyclin D 1 expression in postmenopausal vaginal epithelium

European Journal of Obstetrics and Gynecology and Reproductive Biology

Volumn 121, Issue 1, 2005, Pages 61-66

  Saǧsöz, Nevin ^a   Yücel, Aykan ^a   Noyan, Volkan ^a   Bozdoǧan, Önder ^a  

^a KIRIKKALE UNIVERSITY   (Turkey)

Author keywords

Apoptosis; Bax; Bcl 2; Cyclin D 1; Hormone therapy; Tibolone; Vagina

Indexed keywords

CONJUGATED ESTROGEN; CYCLIN D1; ESTRADIOL VALERATE; ESTROGEN; HORMONE; MARKER; MEDROXYPROGESTERONE ACETATE; PROGESTERONE; PROTEIN BAX; PROTEIN BCL 2; TIBOLONE;

ADULT; APOPTOSIS; ARTICLE; BIOPSY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DATA ANALYSIS; DRUG EFFECT; EPITHELIUM CELL; ESTROGEN THERAPY; FEMALE; HORMONAL THERAPY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KRUSKAL WALLIS TEST; MEASUREMENT; PARAMETER; POSTMENOPAUSE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL; RANK SUM TEST; VAGINA; VAGINA EPITHELIUM;

EID: 21244457890     PISSN: 03012115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejogrb.2004.11.029     Document Type: Article

References (43)

1. A.H. Wyllie, J.F. Kerr, and A.R. Currie Cell death: the significance of apoptosis Int Rev Cytol 68 1980 251 306
2. L.H. Boise, M. Gonzalez-Garcia, and C.E. Postema bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death Cell 74 1993 597 608
3. Z.N. Oltvai, and S.J. Korsmeyer Checkpoints of dueling dimers foil death wishes Cell 79 1994 189 192
4. L. Fesus, P.J.A. Davies, and M. Piacentini Apoptosis: molecular mechanism in programmed cell death Eur J Cell Biol 56 1991 170 177
5. K. Pushkala, and P.D. Gupta Steroid hormones regulate programmed cell death: a review Cytobios 106 2001 201 217
6. E.A. Musgrove, and R.L. Sutherland Cell cycle control by steroid hormones Semin Cancer Biol 5 1994 381 389
7. C.J. Sherr G1 phase progression: cycling on cue Cell 79 1994 551 555
8. Y. Xiong, and D. Beach Population exploration in the cyclin family Curr Biol 1 1991 362 364
9. R. Donnellan, and R. Chetty Cyclin D1 and human neoplasia Mol Pathol 51 1998 1 7
10. 1 expression in the murine mammary epithelial cell, in vivo Endocrinology 138 1997 3933 3939
11. E.A. Musgrove, J.A. Hamilton, C.S. Lee, K.J. Sweeney, C.K. Watts, and R.L. Sutherland Growth factor, steroid, and steroid antagonist regulation of cyclin gene expression associated with changes in T-47D human breast cancer cell cycle progression Mol Cell Biol 13 1993 3577 3587
12. 1 dependent kinase inhibitor p27 (kip1) expression by estrogen in rat endometrium J Steroid Biochem Mol Biol 78 2001 193 199
13. 1 dependent kinases in smooth muscle tumors of the uterus Int J Cancer 84 1999 244 250
14. G. DelSal, M. Loda, and M. Pagano Cell cycle and cancer: critical events at the G1 restriction point Crit Rev Oncog 7 1996 127 242
15. Menopause and the perimenopausal transition L. Speroff R.H. Glass N.G. Kase Clinical Gynecologic Endocrinology and Infertility 1999 Lippincott Williams & Wilkins Baltimore, Maryland 643 724
16. J. Rymer, M.G. Chapman, I. Fogelman, and P.O. Wilson A study of the effect of tibolone on the vagina in postmenopausal women Maturitas 20 1994 127 133
17. F.P. Mandel, F.L. Geola, and D.R. Meldrum Biological effects of various doses of vaginally administered conjugated equine estrogens in postmenopausal women J Clin Endocrinol Metab 57 1983 133 139
18. R.A. Ayton, G.M. Darling, and A.L. Murkies A comparative study of safety and efficacy of continuous low dose oestradiol released from a vaginal ring compared with conjugated equine oestrogen vaginal cream in the treatment of postmenopausal urogenital atrophy Br J Obstet Gynaecol 103 1996 351 358
19. S. Martimbeau, and J.L. Tilly Physiological cell death in endocrine-dependent tissues: an ovarian perspective Clin Endocrinol (Oxf) 46 1997 241 254
20. H. Billig, I. Furuta, and A.J. Hsueh Estrogens inhibit and androgens enhance ovarian granulosa cell apoptosis Endocrinology 133 1993 2204 2212
21. N. Kyprianou, P. Martikainen, L. Davis, H.F. English, and J.T. Isaacs Programmed cell death during regression of the MCF-7 human breast cancer following estrogen ablation Cancer Res 51 1991 162 166
22. A. Suzuki, M. Enari, Y. Abe, Y. Ohta, and T. Iguchi Effect of ovariectomy on histological change and protein expression in female mouse reproductive tracts In Vivo 10 1996 103 110
23. F.D. Bertalanfy, and C. Lau Mitotic rates, renewal times and cytodynamics of the female genital tract epithelia in the rat Acta Anat 54 1963 39 81
24. M.B. Parr, L. Kepple, and E.L. Parr Langerhans cells phagocytose vaginal epithelial cells undergoing apoptosis during the murine estrous cycle Biol Reprod 45 1991 252 260
25. J.R. Berman, M.M. McCarthy, and N. Kyprianou Effect of estrogen withdrawal on nitric oxide synthase expression and apoptosis in the rat vagina Urology 51 1998 650 656
26. T. Sato, Y. Fukazawa, H. Kojima, M. Enari, T. Iguchi, and Y. Ohta Apoptotic cell death during the estrous cycle in the rat uterus and vagina Anat Rec 248 1997 76 83
27. K.S. Rao, S. Zanotti, A.G. Reddy, F. Rauch, H.G. Mannherz, and P.D. Gupta Oestradiol regulated programmed cell death in rat vagina: terminal differentiation or apoptosis Cell Biol Int 22 1998 105 113
28. J.G. Forsberg Cervicovaginal epithelium: its origin and development Am J Obstet Gynecol 115 1973 1025 1043
29. P.D. Gupta, S. Vijayasaradhi, and A.G. Reddy Keratinization of rat vaginal epithelium. III. Effect of estradiol on keratinization Biol Cell 65 1989 281 289
30. K. Rao, A.G. Reddy, and P.D. Gupta Oestradiol regulated keratin gene expression in rat vaginal epithelial cells J Biosci 22 1997 273 285
31. R.R. Polakowska, M. Piacentini, R. Bartlett, L.A. Goldsmith, and A.R. Haake Apoptosis in human skin development: morphogenesis, periderm, and stem cells Dev Dyn 199 1994 176 188
32. R.L. Sutherland, R.R. Reddel, and M.D. Green Effects of oestrogens on cell proliferation and cell cycle kinetics. A hypothesis on the cell cycle effects of antioestrogens Eur J Cancer Clin Oncol 19 1983 307 318
33. C.L. Clarke, and R.L. Sutherland Progestin regulation of cellular proliferation Endocr Rev 11 1990 266 301
34. L. Martin, R.M. Das, and C.A. Finn The inhibition by progesterone of uterine epithelial proliferation in the mouse J Endocrinol 57 1973 549 554
35. 1 and cdk4 nuclear translocation, cyclin E- and cyclin A-cdk2 kinase activation, and cell proliferation in uterine epithelial cells in mice Mol Cell Biol 19 1999 2251 2264
36. L. Martin, C.A. Finn, and G. Trinder DNA synthesis in the endometrium of progesterone-treated mice J Endocrinol 56 1973 303 307
37. R.L. Sutherland, R.E. Hall, G.Y. Pang, E.A. Musgrove, and C.L. Clarke Effect of medroxyprogesterone acetate on proliferation and cell cycle kinetics of human mammary carcinoma cells Cancer Res 48 1988 5084 5091
38. R.L. Sutherland, O.W. Prall, C.K. Watts, and E.A. Musgrove Estrogen and progestin regulation of cell cycle progression J Mammary Gland Biol Neoplasia 3 1998 63 72
39. C.W. Burger, F.E. van Leeuwen, F. Scheele, and P. Kenemans Hormone replacement therapy in women treated for gynaecological malignancy Maturitas 32 1999 69 76
40. K. Nilsson, and G. Heimer Low-dose oestradiol in the treatment of urogenital oestrogen deficiency - a pharmacokinetic and pharmacodynamic study Maturitas 15 1992 121 127
41. 1 in epithelial tissues of transgenic mice results in epidermal hyperproliferation and severe thymic hyperplasia Proc Natl Acad Sci U S A 93 1996 7634 7638
42. R.J. Zaino, S.J. Robboy, and R.J. Kurman Diseases of the vagina RJ. Kurman Blaustein's Pathology of the Female Genital Tract 2002 Springer-Verlag New York 151 199
43. T.H. Cheung, M.M. Yu, K.W. Lo, S.F. Yim, T.K. Chung, and Y.F. Wong Alteration of cyclin D1 and CDK4 gene in carcinoma of uterine cervix Cancer Lett 166 2001 199 206