Development of monoclonal and polyclonal antibodies and an ELISA for the determination of glycodelin in human serum, amniotic fluid and cystic fluid of benign and malignant ovarian tumors

Anticancer Research

Volumn 25, Issue 3 A, 2005, Pages 1581-1589

  Jeschke, Udo ^a   Bischof, Anja ^b   Speer, Runa ^c   Briese, Volker ^b   Richter, Dagmar Ulrike ^b   Bergemann, Claudia ^b   Mylonas, Ioannis ^a   Shabani, Naim ^a   Friese, Klaus ^a   Karsten, Uwe ^d  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF ROSTOCK   (Germany)

^c CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^d MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

ELISA; Glycodelin; Monoclonal antibodies; Ovarian cancer

Indexed keywords

GLYCODELIN A; MONOCLONAL ANTIBODY; PLACENTA PROTEIN 14; POLYCLONAL ANTIBODY; UNCLASSIFIED DRUG;

AMNION FLUID; ANTIBODY DETECTION; BENIGN TUMOR; CANCER DIAGNOSIS; CELL DIFFERENTIATION; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; CYST FLUID; ENZYME LINKED IMMUNOSORBENT ASSAY; GYNECOLOGIC CANCER; HUMAN; HUMAN CELL; HUMAN TISSUE; HYBRIDOMA; IMMUNOADSORPTION; IMMUNOADSORPTION CHROMATOGRAPHY; MALIGNANT NEOPLASTIC DISEASE; MOLECULAR CLONING; MOLECULAR WEIGHT; OVARY TUMOR; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; QUANTITATIVE ANALYSIS; SERUM; STATISTICAL SIGNIFICANCE; WESTERN BLOTTING;

ANTIBODIES; BLOTTING, WESTERN; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GLYCOPROTEINS; HUMANS; OVARIAN NEOPLASMS; PREGNANCY PROTEINS;

EID: 21244457220     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (24)

1. Keil C, Husen B, Giebel J, Rune G and Walther R: Glycodelin mRNA is expressed in the genital tract of male and female rats (Rattus norvegiens). Mol Endocrinol 23: 57-66, 1999.
2. Bohn H, Kraus W and Winckler W: New soluble placental tissue proteins: their isolation, characterization, localization and quantification. Placenta Suppl 4: 67-81, 1982.
3. Petrunin DD, Griaznova IM, Petrunina IA and Tatarinov IS: Comparative immunochemical and physicochemical characteristics of human placental chorionic alpha1- and alpha2-microglobulins. Biull Eksp Biol Med 85: 658-661, 1978.
4. Tatarinov YS, Kozlaeva GA, Petrunin DD and Petrunina YA: Proteins and hormones. In: The Human Placenta, Klopper A, Genazzi A and Crosignani PG (eds) London Academic Press pp. 35-46, 1980.
5. Julkunen M, Koistinen R, Sjoberg J, Rutanen EM, Wahlstrom T and Seppala M: Secretory endometrium synthesizes placental protein 14. Endocrinology 118: 1782-1786, 1986.
6. Julkunen M, Rutanen EM, Koskimies A, Ranta T, Bohn H and Seppala M: Distribution of placental protein 14 in tissues and body fluids during pregnancy. Br J Obstet Gynaecol 92: 1145-1151, 1985.
7. Okamoto N, Uchida A, Takakura K, Kariya Y, Kanzaki H, Riittinen L, Koistinen R, Seppala M and Mori T: Suppression by human placental protein 14 of natural killer cell activity. Am J Reprod Immunol 26: 137-142, 1991.
8. Tomczak S, Briese V, Kunkel S and Muller H: Serum placental protein 14 (PP14) levels in patients with threatened abortion. Arch Gynecol Obstet 258: 165-169, 1996.
9. Dell A, Morris HR, Easton RL, Panico M, Patankar M, Oehniger S, Koistinen R, Koistinen H, Seppala M and Clark GF: Structural analysis of the oligosaccharides derived from glycodelin, a human glycoprotein with potent immunosuppressive and contraceptive activities. J Biol Chem 270: 24116-24126, 1995.
10. Julkunen M, Seppala M and Janne OA: Complete amino acid sequence of human placental protein 14: a progesterone-regulated uterine protein homologous to beta-lactoglobulins. Proc Natl Acad Sci USA 85: 8845-8849, 1988.
11. Koistinen H, Koistinen R, Dell A, Morris HR, Easton RL, Patankar M, Oehniger S, Clark GF and Seppala M: Glycodelin from seminal plasma is a differentially glycosylated form of contraceptive glycodelin A. Mol Hum Reprod 2: 759-765, 1996.
12. Julkunen M, Wahlstrom T, Seppala M, Koistinen R, Koskimies A, Stenman UH and Bohn H: Detection and localization of placental protein 14-like protein in human seminal plasma and in the male genital tract. Arch Androl 12: 59-67, 1984.
13. Seppala M, Suikkari AM, Koistinen R, Riittinen L and Julkunen M: Endometrial protein secretion with respect to endometrial and ovarian function. Eur J Obstet Gynecol Reprod Biol 36: 250-257, 1990.
14. Kamarainen M, Leivo I, Koistinen R, Julkunen M, Karvonen U, Rutanen EM and Seppala M: Normal human ovary and ovarian tumors express glycodelin, a glycoprotein with immunosuppressive and contraceptive properties. Am J Pathol 148: 1435-1443, 1996.
15. Kamarainen M, Riittinen L, Seppala M, Palotie A and Andersson LC: Progesterone-associated endometrial protein-a constitutive marker of human erythroid precursors. Blood 84: 467-473, 1994.
16. Kamarainen M, Halttunen M, Koistinen R, von Boguslawsky K, von Smitten K, Andersson LC and Seppala M: Expression of glycodelin in human breast and breast cancer. Int J Cancer 83: 738-742, 1999.
17. Horowitz IR, Cho C, Song M, Flowers LC, Santanam N, Parthasarathy S and Ramachandran S: Increased glycodelin levels in gynecological malignancies. Int J Gynecol Cancer 11: 173-179, 2001.
18. Kamarainen M, Seppala M, Virtanen I and Andersson LC: Expression of glycodelin in MCF-7 breast cancer cells induces differentiation into organized acinar epithelium. Lab Invest 77: 565-753, 1997.
19. Jeschke U, Wang X, Briese V, Friese K and Stahn R: Glycodelin and amniotic fluid transferrin as inhibitors of E-selectin-mediated cell adhesion. Histochem Cell Biol 119: 345-354, 2003.
20. Mylonas I, Speer R, Makovitzky J, Richter DU, Briese V, Jeschke U and Friese K: Immunohistochemical analysis of steroid receptors and glycodelin A (PP14) in isolated glandular epithelial cells of normal human endometrium. Histochem Cell Biol 114: 405-411, 2000.
21. Riittinen L, Julkunen M, Seppälä M, Koistinen R and Huhtala ML: Purification and characterization of endometrial protein glycodelin A from mid-trimester amniotic fluid. Clin Chim Acta 184: 19-30, 1989.
22. Jeschke U, Richter DU, Walzel H, Bergemann C, Mylonas I, Sharma S, Keil C, Briese V and Friese K: Stimulation of hCG and inhibition of hPL in isolated human trophoblast cells in vitro by glycodelin A. Arch Gynecol Obstet 268: 162-167, 2003.
23. Bergemann C, Reimer T, Müller H, Hösel A, Briese V, Friese K and Jeschke U: Stimulation of hCG Protein and mRNA Levels in Trophoblast Tumour Cells Jeg3 and BeWo by Glycodelin A. Anticancer Res 23: 1107-1114, 2003.
24. Mylonas I, Jeschke U, Makovitzky J, Winkler L, Richter DU, Friese K and Briese V: Immunohistochemical expression of steroid receptors and Glycodelin A in isolated proliferative human endometrial glandular cells after stimulation with Tamoxifen and phytoestrogens (genistein and daidzein). Anticancer Res 23: 1119-1126, 2003.