Comparative study of the disposition of levofloxacin, netilmicin and cefepime in the isolated rat lung

Journal of Pharmacy and Pharmacology

Volumn 57, Issue 7, 2005, Pages 861-867

  Martínez Martínez, María Santos ^a   Colino Gandarillas, Clara Isabel ^a   Martínez Lanao, José ^a   Sánchez Navarro, Amparo ^a  

^a UNIVERSITY OF SALAMANCA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BOVINE SERUM ALBUMIN; CEFEPIME; LEVOFLOXACIN; NETILMICIN;

ANIMAL CELL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; ARTIFICIAL VENTILATION; CONTROLLED STUDY; DRUG DISPOSITION; DRUG DISTRIBUTION; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOLATED LUNG; LUNG PARENCHYMA; LUNG VENTILATION; MALE; NONHUMAN; RAT; TIDAL VOLUME;

EID: 21144452414     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357056479     Document Type: Article

References (47)

1. Andes, D. (2001) Pharmacokinetic and pharmacodynamic properties of antimicrobials in the therapy of respiratory tract infections. Curr. Opin. Infect. Dis. 14: 165-172
2. Barbhaiya, R. H., Forgue, S. T., Gleason, C. R., Knupp, C. A., Pittman, K. A., Weidler, D. J., Movahhed, H., Tenney, J., Martin, R. R. (1992) Pharmacokinetics of cefepime after single and multiple intravenous administrations in healthy subjects. Antimicrob. Agents Chemother. 36: 552-557
3. Breilh, D., Saux, M. C., Delaisement, C., Fratta, A., Ducint, D., Velly, J. F., Couraud, L. (2001) Pharmacokinetic population study to describe cefepime lung concentrations. Pulm. Pharmacol. Ther. 14: 69-74
4. Campoli-Richards, D. M., Chaplin, S., Sayce, R. H., Goa, K. L. (1989) Netilmicin: a review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs 38: 703-756
5. Casquero-Dorado, A. C., Sanchez-Navarro, A. (2000) Determination of tissue spaces of the isolated hindlimb of the rat using netilmicin as an extracellular space indicator. J. Pharm. Pharmacol. 52: 1491-1497
6. Cazzola, M., Matera, M. G., Noschese, P. (2000) Parenteral antibiotic therapy in the treatment of lower respiratory tract infections. Strategies to minimize the development of antibiotic resistance. Pulm. Pharmacol. Ther. 13: 249-256
7. Chang, Y. L., Chou, M. H., Lin, M. F., Chen, C. F., Tsai, T. H. (2001) Determination and pharmacokinetic study of unbound cefepime in rat bile by liquid chromatography with on-line microdialysis. J. Chromatogr. A 20: 77-82
8. Chien, S. C., Rogge, M. C., Gisclon, L. G., Curtin, C., Wong, F., Natarajan, J., Williams, R. R., Fowler, C. L., Cheung, W. K., Chow, A. T. (1997) Pharmacokinetic profile of levofloxacin following once-daily 500-milligram oral or intravenous doses. Antimicrob. Agents Chemother. 41: 2256-2260
9. Chung, M., Costello, R., Symchowicz, S. (1980) Comparison of netilmicin and gentamicin pharmacokinetics in humans. Antimicrob. Agents Chemother. 17: 184-187
10. Colino, C. I., García Turiño, A., Sanchez Navarro, A., Lanao, J. M. (1998) A comparative study of ofloxacin and ciprofloxacin erythrocyte distribution. Biopharm. Drug Dispos. 19: 71-77
11. Conway, S. P., Miller, M. G., Ramsden, C., Littlewood, J. M. (1985) Intensive treatment of pseudomonas chest infection in cystic fibrosis: a comparison of tobramycin and ticarcillin, and netilmicin and ticarcillin. Acta Paediatr. Scand. 74: 107-113
12. Desmoulin, F., Guard, V., Malet-Martino, M., Martino, R. (2002) Metabolism of capecitabine, an oral fluorouracil prodrug: (19)F NMR studies in animal models and human urine. Drug Metab. Dispos. 30: 1221-1229
13. Fish, D. N., Chow, A. T. (1997) The clinical pharmacokinetics of levofloxacin. Clin. Pharmacokinet. 32: 101-119
14. Fraschini, F., Scaglione, F., Ripamonti, L., Maierna, G., Mezzetti, M. (1988) Pharmacokinetics and pulmonary tissue penetration of netilmicin: a comparison of dosage schedules. J. Drug Dev. 1 (Suppl. 3): 129-136
15. Garcia, I., Pascual, A., Ballesta, S., Perea, E. J. (2000) Uptake and intracellular activity of ofloxacin isomers in human phagocytic and non-phagocytic cells. Int. J. Antimicrob. Agents 15: 201-205
16. Hoepelman, A. I., Kieft, H., Aoun, M., Kosmidis, J., Strand, T., Verhoef, J., Gillespie, S. H., Riddell, J., Varghese, G., Meunier, F. (1993) International comparative study of cefepime and ceftazidime in the treatment of serious bacterial infections. J. Antimicrob. Chemother. 32 (Suppl. B): 175-186
17. Huang, C. K., Chen, Y. S., Lee, S. S., Lin, W. R., Tsai, H. C., Lin, H. H., Wann, S. R., Chen, J. Y., Yen, M. Y., Liu, Y. C. (2002) Safety and efficacy of cefepime versus ceftazidime in the treatment of severe infections. J. Microbiol. Immunol. Infect. 35: 159-167
18. Klutman, N. E. (1996) Selecting antibiotics based on pharmacokinetic and pharmacodynamic principles. Pharm. Pract. Manag. Q. 16: 9-12
19. Kovarik, J. M., ter Maaten, J. C., Rademaker, C. M. A., Deenstra, M., Hoepelman, I. M., Hart, H. C., Matzke, G. R., Verhoef, J. (1990) Pharmacokinetics of cefepime in patients with respiratory tract infections. Antimicrob. Agents Chemother. 34: 1885-1888
20. Lanao, J. M., López, A., Domínguez-Gil, A., Martin, J., Gomez, J. R., Tabernero, J. M. (1991) Distribution kinetics of netilmicin in human blister fluid: effect of renal impairment. Biopharm. Drug Dispos. 12: 149-162
21. Lane, A. Z. (1984) Clinical experience with netilmicin. J. Antimicrob. Chemother. 13 (Suppl. A): 67-72
22. Lee, L. J., Sha, X., Gotfried, M. H., Howard, J. R., Dix, R. K., Fish, D. N. (1998) Penetration of levofloxacin into lung tissue after oral administration to subjects undergoing lung biopsy or lobectomy. Pharmacotherapy 18: 35-41
23. Leophonte, P., Bertrand, A., Nouvel, G., Muir, J. F., Lucht, F., Delaval, P., Depierre, A., Hughes, F., Ulmer, M., Gres, J. J. (1993) A comparative study of cefepime and ceftazidime in the treatment of community-acquired lower respiratory tract infections. J. Antimicrob. Chemother. 32 (Suppl. B): 165-173
24. Martínez Martínez, M. S., Colino Gandarillas, C. I., Martínez Lanao, J., Sánchez Navarro, A. (2005) Influence of flow rate on the disposition of levofloxacin and netilmicin in the isolated rat lung. Eur J. Pharm Sci. 24: 325-332
25. McCabe, R., Chirurgi, V., Farkas, S. A., Haddow, A., Heinz, G., Greene, S. (1996) A new therapeutic option for the treatment of pneumonia. Am. J. Med. 24: 100 (6A): 60S-67S
26. Mehendale, H. M., Angevine, L. S., Ohmiya, Y. (1981) The isolated perfused lung: a critical evaluation. Toxicology 21: 1-36
27. Murata, M., Tamai, I., Sai, Y., Nagata, O., Kato, H., Tsuji, A. (1999) Carrier-mediated lung distribution of HSR-903, a new quinolone antibacterial agent. J. Pharmacol. Exp. Ther. 289: 79-84.
28. Nicolau, D. P. (2002) Pharmacodynamic rationale for short-duration antibacterial therapy. J. Infect. 44 (Suppl. A): 17-23
29. North, D. S., Fish, D. N., Redington, J. J. (1998) Levofloxacin, a second-generation fluoroquinolone. Pharmacotherapy 18: 915-935
30. Nye, K. J., Shi, Y. G., Andrews, J. M., Wise, R. (1989) Pharmacokinetics and tissue penetration of cefepime. J. Antimicrob. Chemother. 24: 23-28
31. Okamoto, M. P., Nakahiro, R. K., Chin, A., Bedikian, A. (1993) Cefepime clinical pharmacokinetics. Clin. Pharmacokinet. 25: 88-102
32. Reinoso, R. F., Sánchez-Navarro, A., Lanao, J. M. (1999) Distribution of ciprofloxacin in the isolated rat lung in the presence and absence of tissue oedema. Eur. J. Pharm. Sci. 8: 203-209
33. Roberts, M. S., Rowland, M. (1986a) A dispersion model of hepatic elimination: 1. Formulation of the model and bolus considerations. J. Pharmacokinet. Biopharm. 14: 227-260
34. Roberts, M. S., Rowland, M. (1986b) A dispersion model of hepatic elimination: 2. Steady-state considerations - influence of hepatic blood flow, binding within blood, and hepatocellular enzyme activity. J. Pharmacokinet. Biopharm. 14: 261-288
35. Roberts, M. S., Rowland, M. (1986c) A dispersion model of hepatic elimination: 3. Application to metabolite formation and elimination kinetics. J. Pharmacokinet. Biopharm. 14: 289-308
36. Santos, M., García, E., Lopez, F. G., Lanao, J. M., Domínguez-Gil, A. (1995) Determination of netilmicin in plasma by HPLC. J. Pharm. Biomed. Anal. 13: 1059-1062
37. Svoboda, Z., Nobilis, M., Kvetina, J., Lemr, K. (1999) Study of the biotransformation of benfluron using the isolated perfused rat liver. Acta Medica (Hradec Kralove) 42: 73-78
38. Tronde, A., Krondahl, E., von Euler-Chelpin, H., Brunmark, P., Bengtsson, U. H., Ekstrom, G., Lennernas, H. (2002) High airway-to-blood transport of an opioid tetrapeptide in the isolated rat lung after aerosol delivery. Peptides 23: 469-478
39. von Baum, H., Bottcher, S., Hoffmann, H., Sonntag, H. G. (2001) Tissue penetration of a single dose of levofloxacin intravenously for antibiotic prophylaxis in lung surgery. J. Antimicrob. Chemother. 47: 729-730
40. Wolfgang, F. (1998) Advantages and limitations of isolated organs. Proceedings of workshop on isolated perfused organs. Society for Laboratory Animal Science, Hamburg
41. Yamaoka, K., Nakagawa, T., Uno, T. (1978) Statistical moments in pharmacokinetics. J Pharmacokinet. Biopharm. 6: 547-558
42. Yano, Y., Yamaoka, K., Tanaka, H. (1989) A nonlinear least squares program MULTI (FILT), based on fast inverse Laplace transform for microcomputers. Chem. Pharm. Bull. 37: 1035-1038
43. Zarzuelo, A., Lanao, J. M., Lopez, F. G., Sanchez-Navarro, A. (2002) Influence of the infusion rate on disposition of netilmicin in the isolated rat perfused kidney. Eur. J. Pharm. Sci. 16: 133-141
44. Zhanel, G. G., Noreddin, A. M. (2001) Pharmacokinetics and pharmacodynamics of the new fluoroquinolones: focus on respiratory infections. Curr. Opin. Pharmacol. 1: 459-463
45. Zhanel, G. G., Ennis, K., Vercaigne, L., Walkty, A., Gin, A. S., Embil, J., Smith, H., Hoban, D. J. (2002) A critical review of the fluoroquinolones: focus on respiratory infections. Drugs. 62: 13-59.
46. Erratum in: Drugs (2002) 62: 944
47. Zhao, C., Li, J., Hou, J., Guo, M., Zhang, Y., Chen, Y. (2000) A randomized controlled clinical trial on etimicin, a new aminoglycoside antibiotic, versus netilmicin in the treatment of bacterial infections. Chin. Med. J. (Engl.) 113: 1026-1030d