Cyclohexylmethylpiperidinyltriphenylpropioamide: A selective muscarinic M3 antagonist discriminating against the other receptor subtypes

Journal of Medicinal Chemistry

Volumn 45, Issue 4, 2002, Pages 984-987

  Sagara, Yufu ^a   Sagara, Takeshi ^a   Mase, Toshiaki ^a   Kimura, Toshifumi ^a   Numazawa, Tomoshige ^a   Fujikawa, Toru ^a   Noguchi, Kazuhito ^a   Ohtake, Norikazu ^a  

^a TAIHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOHEXYLMETHYLPIPERIDINYLTRIPHENYLPROPIOAMIDE; MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR ANTAGONIST; MUSCARINIC M4 RECEPTOR; MUSCARINIC M5 RECEPTOR; MUSCARINIC RECEPTOR; N [2 [3 [[1 (CYCLOHEXYLMETHYL) 3 PIPERIDINYL]METHYLAMINO] 3 OXOPROPYL]AMINO 2 OXOETHYL] 3,3,3 TRIPHENYLPRIOPIOAMIDE; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHOLINERGIC RECEPTOR BLOCKING; COMBINATORIAL LIBRARY; DRUG DISCRIMINATION; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; NONHUMAN; PHARMACOPHORE;

ACETYLCHOLINE; ANIMALS; BRADYCARDIA; BRONCHOCONSTRICTION; CARBACHOL; CHO CELLS; CHOLINERGIC AGENTS; COMBINATORIAL CHEMISTRY TECHNIQUES; CRICETINAE; DIPEPTIDES; HEART ATRIA; HUMANS; MUSCARINIC ANTAGONISTS; PIPERIDINES; RATS; RECEPTOR, MUSCARINIC M3; RECEPTORS, MUSCARINIC; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037075080     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010480k     Document Type: Article

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