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Volumn 100, Issue 3, 2005, Pages 325-329

Benznidazole-induced genotoxicity in diploid cells of Aspergillus nidulans

Author keywords

Benznidazole; Genotoxicity; Homozigotization index; Somatic recombination

Indexed keywords

ANTIPARASITIC AGENT; BENZNIDAZOLE;

EID: 21044452784     PISSN: 00740276     EISSN: None     Source Type: Journal    
DOI: 10.1590/s0074-02762005000300020     Document Type: Article
Times cited : (14)

References (40)
  • 1
    • 21044439528 scopus 로고    scopus 로고
    • Treatment with benznidazole in association with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi: Investigation into the possible development of neoplasias
    • Andrade SG, Mesquita IMO, Jambeiro JF, Santos IFM, Portella RS 2003. Treatment with benznidazole in association with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi: investigation into the possible development of neoplasias. Rev Soc Bras Med Trop 31: 373-383.
    • (2003) Rev Soc Bras Med Trop , vol.31 , pp. 373-383
    • Andrade, S.G.1    Mesquita, I.M.O.2    Jambeiro, J.F.3    Santos, I.F.M.4    Portella, R.S.5
  • 2
    • 0027196120 scopus 로고
    • Mechanism of multistep carcinogenesis ans carcinogen risk assessment
    • Barrett JC 1993. Mechanism of multistep carcinogenesis ans carcinogen risk assessment. Environ Health Perspect 100: 9-20.
    • (1993) Environ Health Perspect , vol.100 , pp. 9-20
    • Barrett, J.C.1
  • 3
    • 0031710931 scopus 로고    scopus 로고
    • Induced chromosomal exchange directs the segregation of recombinant chromatids in mitosis of Drosophila
    • Beumer KJ, Pimpinelli S, Golic KG 1998. Induced chromosomal exchange directs the segregation of recombinant chromatids in mitosis of Drosophila. Genet 150: 173-188.
    • (1998) Genet , vol.150 , pp. 173-188
    • Beumer, K.J.1    Pimpinelli, S.2    Golic, K.G.3
  • 5
    • 1342289544 scopus 로고    scopus 로고
    • Cremophor EL stimulates mitotic recombination in uvsH//uvsH diploid strain of Aspergillus nidulans
    • Busso C, Castro-Prado MAA 2004. Cremophor EL stimulates mitotic recombination in uvsH//uvsH diploid strain of Aspergillus nidulans. Ann Braz Acad Sci 76: 49-55.
    • (2004) Ann Braz Acad Sci , vol.76 , pp. 49-55
    • Busso, C.1    Castro-Prado, M.A.A.2
  • 6
    • 0005939078 scopus 로고    scopus 로고
    • uvsH//uvsH diploid strain allowing an efficient method to evaluate the recombinagenic effect of chemical and physical agents in Aspergillus nidulans
    • Busso C, Chiuchetta SJR, Baptista F, Castro-Prado MAA 2001. uvsH//uvsH diploid strain allowing an efficient method to evaluate the recombinagenic effect of chemical and physical agents in Aspergillus nidulans. Act Scientiarum 23: 603-607.
    • (2001) Act Scientiarum , vol.23 , pp. 603-607
    • Busso, C.1    Chiuchetta, S.J.R.2    Baptista, F.3    Castro-Prado, M.A.A.4
  • 8
    • 0025730459 scopus 로고
    • Molecular genetics of human cancer predisposition and progression
    • Cavenee WK, Scrable HJ, James CD 1991. Molecular genetics of human cancer predisposition and progression. Mutat Res 247: 199-202.
    • (1991) Mutat Res , vol.247 , pp. 199-202
    • Cavenee, W.K.1    Scrable, H.J.2    James, C.D.3
  • 9
    • 0036086350 scopus 로고    scopus 로고
    • Vincristine induces somatic segregation, via mitotic crossing-over, in diploid cells of Aspergillus nidulans
    • Chiuchetta SJR, Castro-Prado MAA 2002. Vincristine induces somatic segregation, via mitotic crossing-over, in diploid cells of Aspergillus nidulans. Biol Res 35: 31-38.
    • (2002) Biol Res , vol.35 , pp. 31-38
    • Chiuchetta, S.J.R.1    Castro-Prado, M.A.A.2
  • 10
    • 0000466679 scopus 로고
    • Linkage map and locus list
    • SD Martinelli, JR Kinghorn (eds), Elsevier, Amsterdam
    • Chutterbuck AJ 1994. Linkage map and locus list. In SD Martinelli, JR Kinghorn (eds), Aspergillus: 50 years on, Elsevier, Amsterdam, p. 791-824.
    • (1994) Aspergillus: 50 Years on , pp. 791-824
    • Chutterbuck, A.J.1
  • 11
    • 0031623294 scopus 로고    scopus 로고
    • Community participation and control of endemic diseases in Brazil: Problems and possibilities
    • Dias JC 1998. Community participation and control of endemic diseases in Brazil: problems and possibilities. Cad Saúde Pública 14 (Supl. 2): 19-37.
    • (1998) Cad Saúde Pública , vol.14 , Issue.2 SUPL , pp. 19-37
    • Dias, J.C.1
  • 12
    • 0023874399 scopus 로고
    • Activation of anti-Trypanosoma cruzi drugs to genotoxic metabolites promoted by mammalian microsomal enzymes
    • Ferreira RCC, Schwarz U, Ferreira LCS 1988. Activation of anti-Trypanosoma cruzi drugs to genotoxic metabolites promoted by mammalian microsomal enzymes. Mutat Res 204: 577-583.
    • (1988) Mutat Res , vol.204 , pp. 577-583
    • Ferreira, R.C.C.1    Schwarz, U.2    Ferreira, L.C.S.3
  • 14
    • 0031020894 scopus 로고    scopus 로고
    • On the recombinagenic activity of norfloxacin in a diploid strain of Aspergillus nidulans
    • Franzoni MGM, Castro-Prado MAA, Gebara JS 1997. On the recombinagenic activity of norfloxacin in a diploid strain of Aspergillus nidulans. Cytologia 62: 39-45.
    • (1997) Cytologia , vol.62 , pp. 39-45
    • Franzoni, M.G.M.1    Castro-Prado, M.A.A.2    Gebara, J.S.3
  • 15
    • 0031825679 scopus 로고    scopus 로고
    • Effects of DNA-double-strand and single-strand breaks on intrachromosomal recombination events in cell-cycle-arrested yeast cells
    • Galli A, Schiestl RH 1998. Effects of DNA-double-strand and single-strand breaks on intrachromosomal recombination events in cell-cycle-arrested yeast cells. Genet 149: 1235-1250.
    • (1998) Genet , vol.149 , pp. 1235-1250
    • Galli, A.1    Schiestl, R.H.2
  • 16
    • 0022578867 scopus 로고
    • Interaction of benznidazole reactive metabolites with rat liver deoxyribonucleic acid and nuclear proteins
    • Gorla N, Diaz Gomez MI, Castro JA 1986. Interaction of benznidazole reactive metabolites with rat liver deoxyribonucleic acid and nuclear proteins. Arch Int Pharmacodyn Ther 280: 22-31.
    • (1986) Arch Int Pharmacodyn Ther , vol.280 , pp. 22-31
    • Gorla, N.1    Diaz Gomez, M.I.2    Castro, J.A.3
  • 17
    • 0023695126 scopus 로고
    • Assessment of cytogenetic damage in chagasic children treated with benznidazole
    • Gorla N, Ledesma OS, Barbieri GP, Larripa IB 1988. Assessment of cytogenetic damage in chagasic children treated with benznidazole. Mutat Res 206: 217-220.
    • (1988) Mutat Res , vol.206 , pp. 217-220
    • Gorla, N.1    Ledesma, O.S.2    Barbieri, G.P.3    Larripa, I.B.4
  • 18
    • 0033020244 scopus 로고    scopus 로고
    • Mitotic recombination map of 13cen-13q14 deried from in investigation of loss of heterozygosity in retinoblastomas
    • Hagstrom SA, Dryja TP 1999. Mitotic recombination map of 13cen-13q14 deried from in investigation of loss of heterozygosity in retinoblastomas. Proc Natl Acad Sci USA 96: 2952-2957.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 2952-2957
    • Hagstrom, S.A.1    Dryja, T.P.2
  • 19
    • 0344845194 scopus 로고    scopus 로고
    • Pathways for mitotic homologous recombination in mammalian cells
    • Helleday T 2003. Pathways for mitotic homologous recombination in mammalian cells. Mutat Res 532: 103-115.
    • (2003) Mutat Res , vol.532 , pp. 103-115
    • Helleday, T.1
  • 20
    • 0028349232 scopus 로고
    • The anticlastogenic effect of tocopherol in peritoneal macrophages of benznidazole-treated and ovariectomized mice
    • Lacava ZG, Luna H 1994. The anticlastogenic effect of tocopherol in peritoneal macrophages of benznidazole-treated and ovariectomized mice. Mutat Res 305: 145-150.
    • (1994) Mutat Res , vol.305 , pp. 145-150
    • Lacava, Z.G.1    Luna, H.2
  • 21
    • 0026335851 scopus 로고
    • Loss of constitutional heterozyogosity in human cancer
    • Lasko D, Cavenee W, Nordenskjold M 1991. Loss of constitutional heterozyogosity in human cancer. Annu Rev Genet 25: 281-314.
    • (1991) Annu Rev Genet , vol.25 , pp. 281-314
    • Lasko, D.1    Cavenee, W.2    Nordenskjold, M.3
  • 22
    • 0025087052 scopus 로고
    • Screening the mutagenic activities of commonly used antiparasite drugs by the Simultes, a simplified Salmonella/microsome plate incorporation assay
    • Melo ME, Ferreira LC 1990. Screening the mutagenic activities of commonly used antiparasite drugs by the Simultes, a simplified Salmonella/microsome plate incorporation assay. Rev Inst Med Trop São Paulo 32: 269-274.
    • (1990) Rev Inst Med Trop São Paulo , vol.32 , pp. 269-274
    • Melo, M.E.1    Ferreira, L.C.2
  • 23
    • 0025369436 scopus 로고
    • Molecular nature of in vivo mutations in human cells at the autosomal HLA-A locus
    • Morley AA, Grist SA, Turner DR, Kutlaca A, Bennett G 1990. Molecular nature of in vivo mutations in human cells at the autosomal HLA-A locus. Cancer Res 50: 4584-4587.
    • (1990) Cancer Res , vol.50 , pp. 4584-4587
    • Morley, A.A.1    Grist, S.A.2    Turner, D.R.3    Kutlaca, A.4    Bennett, G.5
  • 24
    • 0024164080 scopus 로고
    • Enfermedade de chagas: Efecto clastogenico de nifurtimox y benznidazol en niños
    • Moya PR, Trombotto GT 1988. Enfermedade de chagas: Efecto clastogenico de nifurtimox y benznidazol en niños. Medicina 48: 487-491.
    • (1988) Medicina , vol.48 , pp. 487-491
    • Moya, P.R.1    Trombotto, G.T.2
  • 25
    • 0020533189 scopus 로고
    • Mutagenicity of 2 anti-chagasic drugs and their metabolic deactivation
    • Nagel R, Nepomnaschy I 1983. Mutagenicity of 2 anti-chagasic drugs and their metabolic deactivation. Mutat Res 117: 237-242.
    • (1983) Mutat Res , vol.117 , pp. 237-242
    • Nagel, R.1    Nepomnaschy, I.2
  • 26
    • 0028587643 scopus 로고
    • A new method to detect potential genotoxic agensts using mitotic crossing over in diploid strains of Aspergillus nidulans
    • Pires LTA, Zucchi TMAD 1994. A new method to detect potential genotoxic agensts using mitotic crossing over in diploid strains of Aspergillus nidulans. Braz J Genet 17: 371-376.
    • (1994) Braz J Genet , vol.17 , pp. 371-376
    • Pires, L.T.A.1    Zucchi, T.M.A.D.2
  • 29
    • 0001776640 scopus 로고
    • Production of heterozygous in filamentous fungi
    • Roper JA 1952. Production of heterozygous in filamentous fungi. Experientia 8: 14-15.
    • (1952) Experientia , vol.8 , pp. 14-15
    • Roper, J.A.1
  • 30
    • 0028045020 scopus 로고
    • Cytogenetic effects of the antichagasic benznidazole on human cells in vitro
    • Santos SJ, Takahashi, CS, Natarajan, AT 1994. Cytogenetic effects of the antichagasic benznidazole on human cells in vitro. Mutat Res 320: 305-314.
    • (1994) Mutat Res , vol.320 , pp. 305-314
    • Santos, S.J.1    Takahashi, C.S.2    Natarajan, A.T.3
  • 31
    • 0037221249 scopus 로고    scopus 로고
    • Extensive loss of heterozygosity is suppressed during homologous repair of chromosomal breaks
    • Stark JM, Jasin M 2003. Extensive loss of heterozygosity is suppressed during homologous repair of chromosomal breaks. Mol Cell Biology 23: 733-743.
    • (2003) Mol Cell Biology , vol.23 , pp. 733-743
    • Stark, J.M.1    Jasin, M.2
  • 32
    • 0028203817 scopus 로고
    • Chagas' disease: Carcinogenic activity of the antitrypanosomal nitroarenes in mice
    • Teixeira AR, Calixto MA, Teixeira ML 1994. Chagas' disease: carcinogenic activity of the antitrypanosomal nitroarenes in mice. Mutat Res 305: 189-196.
    • (1994) Mutat Res , vol.305 , pp. 189-196
    • Teixeira, A.R.1    Calixto, M.A.2    Teixeira, M.L.3
  • 33
    • 0017817845 scopus 로고
    • Meiotic recombination in a duplication strian of Aspergillus nidulans
    • Van de Vate C, Jansen GJO 1978. Meiotic recombination in a duplication strian of Aspergillus nidulans. Gen Res 31: 29-52
    • (1978) Gen Res , vol.31 , pp. 29-52
    • Van De Vate, C.1    Jansen, G.J.O.2
  • 34
    • 0016813184 scopus 로고
    • The mutagenic action of nitroimidazoles II. Effects of 2-nitroimidazoles
    • Voogd CE, Van der Stel, JJ, Jacobs JJJAA 1975. The mutagenic action of nitroimidazoles II. Effects of 2-nitroimidazoles. Mutat Res 31: 149-152.
    • (1975) Mutat Res , vol.31 , pp. 149-152
    • Voogd, C.E.1    Van Der Stel, J.J.2    Jacobs, J.J.J.A.A.3
  • 35
    • 0026337295 scopus 로고
    • Tumor suppressor genes
    • Weinberg RA 1991. Tumor suppressor genes. Science 254: 1138-1146.
    • (1991) Science , vol.254 , pp. 1138-1146
    • Weinberg, R.A.1
  • 38
    • 0015054361 scopus 로고
    • Genetics aspects of carcinogenesis
    • Zimmermann FK 1971. Genetics aspects of carcinogenesis. Biochem Pharmacol 20: 985-995
    • (1971) Biochem Pharmacol , vol.20 , pp. 985-995
    • Zimmermann, F.K.1
  • 39
    • 0026485240 scopus 로고
    • Test for recombinagens ins fungi
    • Zimmermann FK 1992. Test for recombinagens ins fungi. Mutat Res 284: 147-158.
    • (1992) Mutat Res , vol.284 , pp. 147-158
    • Zimmermann, F.K.1
  • 40
    • 0025066364 scopus 로고
    • Isolation of a putative recombination mutant of Aspergillus nidulans
    • Zucchi TMAD 1990. Isolation of a putative recombination mutant of Aspergillus nidulans. Braz J Genetic 13: 409-429.
    • (1990) Braz J Genetic , vol.13 , pp. 409-429
    • Zucchi, T.M.A.D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.