2005 Update: Impact of pancreas and islet transplants on acute and chronic complications of diabetes

Current Opinion in Organ Transplantation

Volumn 10, Issue 2, 2005, Pages 176-180

  Robertson, R Paul ^a  

^a PACIFIC NORTHWEST RESEARCH INSTITUTE   (United States)

Author keywords

Diabetic complications; Islet transplantation; Longevity of glucose control

Indexed keywords

GLUCAGON; GLUCOSE; INSULIN;

ACUTE DISEASE; CHRONIC DISEASE; DIABETES CONTROL; DIABETES MELLITUS; DIABETIC ANGIOPATHY; DIABETIC KETOACIDOSIS; DIABETIC NEPHROPATHY; DIABETIC NEUROPATHY; DIABETIC RETINOPATHY; GLUCAGON RELEASE; GLUCOSE BLOOD LEVEL; GRAFT SURVIVAL; HUMAN; HYPEROSMOLAR COMA; HYPOGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; LONGEVITY; PANCREAS ISLET TRANSPLANTATION; PANCREAS TRANSPLANTATION; PATIENT SELECTION; QUALITY OF LIFE; REVIEW; SURVIVAL; SURVIVAL RATE; SYSTEMATIC REVIEW;

EID: 21044448370     PISSN: 10872418     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mot.0000163355.12317.37     Document Type: Review

References (27)

1. DCCT. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993; 329:977-985.
2. Ohkubo Y, Kishikawa H, Araki E, et al. Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study. Diabetes Res Clin Pract 1995; 28:103-117.
3. Robertson R. Pancreas and islet transplants for patients with diabetes: Taking positions and making decisions. Endocr Pract 1999; 5:24-28.
4. Pyzdrowski KL, Kendall DM, Halter JB, et al. Preserved insulin secretion and insulin independence in recipients of islet autografts. N Engl J Med 1992; 327:220-226.
5. Wahoff DC, Papalois BE, Najarian JS, et al. Autologous islet transplantation to prevent diabetes after pancreatic resection. Ann Surg 1995; 222:562-575; discussion 575-569.
6. Shapiro AM, Lakey JR, Ryan EA, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 2000; 343:230-238. ([see comments])
7. Ryan EA, Lakey JR, Paty BW, et al. Successful islet transplantation: continued insulin reserve provides long-term glycemic control. Diabetes 2002; 51:2148-2157.
8. Robertson RP. Islet transplantation as a treatment for diabetes-a work in progress. N Engl J Med 2004; 350:694-705. Recent comprehensive review of the strengths and weaknesses of islet transplantation in the context of outcomes with successful pancreas transplantaton.
9. Diem P, Abid M, Redmon JB, et al. Systemic venous drainage of pancreas allografts as independent cause of hyperinsulinemia in type I diabetic recipients. Diabetes 1990; 39:534-540.
10. Kendall DM, Rooney DP, Smets YF, et al. Pancreas transplantation restores epinephrine response and symptom recognition during hypoglycemia in patients with long-standing type I diabetes and autonomic neuropathy. Diabetes 1997; 46:249-257.
11. Barrou Z, Seaquist ER, Robertson RP. Pancreas transplantation in diabetic humans normalizes hepatic glucose production during hypoglycemia. Diabetes 1994; 43:661-666.
12. Kendall DM, Teuscher AU, Robertson RP. Defective glucagon secretion during sustained hypoglycemia following successful islet allo- and autotransplantation in humans. Diabetes 1997; 46:23-27.
13. Paty BW, Ryan EA, Shapiro AM, et al. Intrahepatic islet transplantation in type 1 diabetic patients does not restore hypoglycemic hormonal counterregulation or symptom recognition after insulin independence. Diabetes 2002; 51:3428-3434.
14. Gupta V, Wahoff DC, Rooney DP, et al. The defective glucagon response from transplanted intrahepatic pancreatic islets during hypoglycemia is transplantation site-determined. Diabetes 1997; 46:28-33.
15. Robertson RP. Transplanted Intrahepatic Islets: Enigmatic absence of the alpha cell response to hypoglycemia. Diab Nutr Metab 2002; 15:433-437.
16. Ryan EA. Oral presentation at the Rachmiel Levine Symposium, Los Angeles, 2004. Report from Edmonton indicating that the majority of islet recipients have returned to insulin therapy after an average of 3 years' post-transplant follow-up.
17. Bohman SO, Tyden G, Wilczek H, et al. Prevention of kidney graft diabetic nephropathy by pancreas transplantation in man. Diabetes 1985; 34:306-308.
18. Bilous RW, Mauer SM, Sutherland DE, et al. The effects of pancreas transplantation on the glomerular structure of renal allografts in patients with insulin-dependent diabetes. N Engl J Med 1989; 321:80-85.
19. Fioretto P, Steffes MW, Sutherland DE, et al. Reversal of lesions of diabetic nephropathy after pancreas transplantation. N Engl J Med 1998; 339: 69-75.
20. Navarro X, Sutherland DE, Kennedy WR. Long-term effects of pancreatic transplantation on diabetic neuropathy. Ann Neurol 1997; 42:727-736.
21. Navarro X, Kennedy WR, Loewenson RB, Sutherland DE. Influence of pancreas transplantation on cardiorespiratory reflexes, nerve conduction, and mortality in diabetes mellitus. Diabetes 1990; 39:802-806.
22. Ramsay RC, Goetz FC, Sutherland DE, et al. Progression of diabetic retinopathy after pancreas transplantation for insulin-dependent diabetes mellitus. N Engl J Med 1988; 318:208-214.
23. Koznarova R, Saudek F, Sosna T, et al. Beneficial effect of pancreas and kidney transplantation on advanced diabetic retinopathy. Cell Transplant 2000; 9:903-908.
24. UKPDS UPDSG. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998; 352:837-853.
25. Jukema JW, Smets YF, van der Pijl JW, et al. Impact of simultaneous pancreas and kidney transplantation on progression of coronary atherosclerosis in patients with end-stage renal failure due to type 1 diabetes. Diabetes Care 2002; 25:906-911.
26. Gruessner RW, Sutherland DE, Gruessner AC. Mortality assessment for pancreas transplants. Am J Transplant 2004; 4:2018-2026. Recent analysis of patient mortality performed in rebuttal to conclusions drawn by Reference [27] claiming that pancreas transplantation increases patient mortality.
27. Venstram JM, McBride MA, Rother KI, et al. Survival after pancreas transplantation in patients with diabetes and preserved kidney function. JAMA 2003; 290:2817-2823.