Design, synthesis, and biological evaluation of new territrem B analogues

Chemistry and Biodiversity

Volumn 2, Issue 4, 2005, Pages 557-567

  Jiang, Xiangrui ^a   Ao, Lei ^a   Zhou, Changxin ^a   Yang, Leixiang ^a   Zhang, Qijun ^a   Li, Haibo ^a   Sun, Lianli ^a   Wu, Xiumei ^b   Bai, Hua ^b   Zhao, Yu ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b Zhejiang Hisun Naturelite Pharmaceutical R and D Co Ltd   (China)

Author keywords

[No Author keywords available]

Indexed keywords

4 [[6 (2 BROMO 4,5 DIMETHOXYPHENYL) 2 OXO 2H PYRAN 3 YL]METHYL]PIPERAZINE 1 CARBOXYLIC ACID ETHYL ESTER; 4 [[[6 (2 BROMO 4,5 DIMETHOXYPHENYL) 2 OXO 2H PYRAN 3YL]METHYL]AMINO] 1,2 DIHYDRO 1,5 DIMETHYL 2 PHENYL 3H PYRAZOL 3 ONE; 6 (2 BROMO 4,5 DIMETHOXYPHENYL) 3 [(2 METHYLQUINOLIN 8 YLOXY)METHYL] 2H PYRAN 2 ONE; 6 (2 BROMO 4,5 DIMETHOXYPHENYL) 3 [(3,5 DICHLOROPHENOXY)METHYL] 2H PYRAN 2 ONE; 6 (2 BROMO 4,5 DIMETHOXYPHENYL) 3 [(4 CYCLOHEXYLPIPERAZIN 1 YL)METHYL] 2H PYRAN 2 ONE; 6 (2 BROMO 4,5 DIMETHOXYPHENYL) 3 [(4 METHOXYPHENOXY)METHYL] 2H PYRAN 2 ONE; 6 (2 BROMO 4,5 DIMETHOXYPHENYL) 3 [(4 NITROPHENOXY)METHYL] 2H PYRAN 2 ONE; 6 (2 BROMO 4,5 DIMETHOXYPHENYL) 3 [(9H FLUOREN 2 YL AMINO)METHYL] 2H PYRAN 2 ONE; 6 (2 BROMO 4,5 DIMETHOXYPHENYL) 3 [(ISOQUINOLIN 5 YLOXY)METHYL] 2H PYRAN 2 ONE; 6 (2 BROMO 4,5 DIMETHOXYPHENYL) 3 [(MORPHOLIN 4 YL AMINO)METHYL] 2H PYRAN 2 ONE; 6 (2 BROMO 4,5 DIMETHOXYPHENYL) 3 [(NAPHTHALEN 1 YL AMINO)METHYL] 2H PYRAN 2 ONE; 6 (2 BROMO 4,5 DIMETHOXYPHENYL) 3 [(PHENYLAMINO)METHYL] 2H PYRAN 2 ONE; 6 (2 BROMO 4,5 DIMETHOXYPHENYL) 3 [(PYRIDIN 2 YL AMINO)METHYL] 2H PYRAN 2 ONE; 6 (2 BROMO 4,5 DIMETHOXYPHENYL) 3 [[(2 CHLOROPYRIDIN 3 YL)AMINO]METHYL] 2H PYRAN 2 ONE; 6 (2 BROMO 4,5 DIMETHOXYPHENYL) 3 [[(4 CHLOROPHENYL)AMINO]METHYL] 2H PYRAN 2 ONE; 6 (2 BROMO 4,5 DIMETHOXYPHENYL) 3 [[(4 METHOXYPHENYL)AMINO]METHYL] 2H PYRAN 2 ONE; 6 (2 BROMO 4,5 DIMETHOXYPHENYL) 3 [[(4,6 DICHLOROPYRIMIDIN 2 YL)AMINO]METHYL] 2H PYRAN 2 ONE; 6 (2 BROMO 4,5 DIMETHOXYPHENYL) 3 [[(4,6 DIMETHYLPYRIMIDIN 2 YL)AMINO]METHYL] 2H PYRAN 2 ONE; 6 (2 BROMO 4,5 DIMETHOXYPHENYL) 3 [[(5 CHLOROPYRIDIN 2 YL)AMINO]METHYL] 2H PYRAN 2 ONE; 6 (2 BROMO 4,5 DIMETHOXYPHENYL) 3 [[(6 METHYLPYRIDIN 2 YL)AMINO]METHYL] 2H PYRAN 2 ONE; 6 (2 BROMO 4,5 DIMETHOXYPHENYL) 3 [[(FURAN 2 YLMETHYL)AMINO]METHYL] 2H PYRAN 2 ONE; 6 (2 BROMO 4,5 DIMETHOXYPHENYL) 3 [[4 (PYRIMIDIN 2 YL)PIPERAZIN 1 YL]METHYL] 2H PYRAN 2 ONE; ARISUGACIN A; ARISUGACIN B; CHOLINESTERASE INHIBITOR; CISPLATIN; ESTERASE INHIBITOR; TERRITREM A; TERRITREM B; TERRITREM B DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CONFORMATION; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CHOLINESTERASE INHIBITORS; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRANS;

EID: 21044440985     PISSN: 16121872     EISSN: 16121880     Source Type: Journal    
DOI: 10.1002/cbdv.200590036     Document Type: Article

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