The role of sequential administration of sulphadoxine/pyrimethamine following quinine in the treatment of severe falciparum malaria in children

Tropical Medicine and International Health

Volumn 10, Issue 5, 2005, Pages 484-488

  Ogutu, B R ^a,b   Nzila, A M ^a   Ochong, E ^a   Mithwani, S ^a   Wamola, B ^a   Olola, C H O ^a   Lowe, B ^a   Kokwaro, G O ^a,c   Marsh, K ^a,d   Newton, C R J C ^a,e  

^a KEMRI WELLCOME TRUST RESEARCH PROGRAMME   (Kenya)

^b Walter Reed Project Centre for Clinical Research KEMRI   (Kenya)

^c UNIVERSITY OF NAIROBI   (Kenya)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Children; Quinine; Severe malaria; Sulphadoxine pyrimethamine

Indexed keywords

DIHYDROFOLATE REDUCTASE; DIHYDROPTEROATE SYNTHASE; FANSIDAR; HEMOGLOBIN; QUININE;

DISEASE TREATMENT; MALARIA; QUININE;

ARTICLE; BLOOD EXAMINATION; BLOOD SMEAR; CLINICAL EXAMINATION; CODON; DISEASE SEVERITY; DRUG DOSE REGIMEN; DRUG EFFICACY; FEMALE; FEVER; GENE MUTATION; GENOTYPE; HEMOGLOBIN DETERMINATION; HUMAN; KENYA; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MALE; NONHUMAN; PARASITE ISOLATION; PARASITEMIA; PRESCHOOL CHILD; PROTOZOAL GENETICS; SINGLE DRUG DOSE; TREATMENT FAILURE; TREATMENT OUTCOME;

ADMINISTRATION, ORAL; ANIMALS; ANTIMALARIALS; CHILD, PRESCHOOL; DRUG ADMINISTRATION SCHEDULE; DRUG COMBINATIONS; FEMALE; HUMANS; INFANT; INFUSIONS, PARENTERAL; MALARIA, FALCIPARUM; MALE; PYRIMETHAMINE; QUININE; SULFADOXINE; TREATMENT OUTCOME;

AFRICA; EAST AFRICA; EASTERN HEMISPHERE; SUB-SAHARAN AFRICA; WORLD;

CINCHONA PUBESCENS;

EID: 21044438591     PISSN: 13602276     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-3156.2005.01415.x     Document Type: Article

References (13)

1. Athan E, Durrheim DN, Barnes K, Mngomezulu NM, Mabuza A & Govere J (2001) Effectiveness of short-course quinine and single-dose sulfadoxine-pyrimethamine in the treatment of Plasmodium falciparum malaria in Mpumalanga Province, South Africa. South African Medical Journal 91, 592-594.
2. Mberu EK, Mosobo MK, Nzila AM, Kokwaro GO, Sibley CH & Watkins WM (2000) The changing in vitro susceptibility pattern to pyrimethamine/sulfadoxine in Plasmodium falciparum field isolates from Kilifi, Kenya. American Journal of Tropical Medicine and Hygiene 62, 396-401.
3. Newton CR, Winstanley PA, Watkins WM et al. (1993) A single dose of intramuscular sulfadoxine-pyrimethamine as an adjunct to quinine in the treatment of severe malaria: pharmacokinetics and efficacy. Transactions of the Royal Society of Tropical Medicine and Hygiene 87, 207-210.
4. Njuguna P & Newton CRJC (2004) Management of severe falciparum malaria. Journal of Postgraduate Medicine 50, 45-50.
5. Nzila AM, Mberu EK, Sulo J et al. (2000) Towards an understanding of the mechanism of pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: genotyping of dihydrofolate reductase and dihydropteroate synthase of Kenyan parasites. Antimicrobial Agents and Chemotherapy 44, 991-996.
6. Ogutu BR, Smoak BL, Nduati RW, Mbori-Ngacha DA, Mwathe F & Shanks GD (2000) The efficacy of pyrimethamine-sulfadoxine (Fansidar®) in the treatment of uncomplicated Plasmodium falciparum malaria in Kenyan children. Transactions of the Royal Society of Tropical Medicine and Hygiene 94, 83-84.
7. Ogutu BR, Newton CR, Crawley J et al. (2002) Pharmacokinetics and anticonvulsant effects of diazepam in children with severe falciparum malaria and convulsions. British Journal of Clinical Pharmacology 53, 49-57.
8. Sibley CH, Hyde JE, Sims PF et al. (2001) Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: what next? Trends Parasitology 17, 582-588.
9. Snow RW, Howard SC, Mung'ala-Odera V et al. (2000) Paediatric survival and readmission risk following hospitalization on the Kenyan Coast. Tropical Medicine and International Health 5, 378-383.
10. WHO (1996) Assessment of therapeutic efficacy of antimalarial drugs for uncomplicated falciparum malaria in areas with intense transmission. Unpublished document, WHO/MAL/96.1077. WHO, Geneva.
11. WHO (2000) Severe falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene 94 (Suppl 1).
12. Winstanley PA, Mberu EK, Watkins WM, Murphy SA, Lowe B & Marsh K (1994) Towards optimal regimens of parenteral quinine for young African children with cerebral malaria: unbound quinine concentrations following a simple loading dose regimen. Transactions of the Royal Society of Tropical Medicine and Hygiene 88, 577-580.
13. Zucker JR, Lackritz EM, Ruebush TK et al. (1996) Childhood mortality during and after hospitalization in western Kenya: effect of malaria treatment regimens. American Journal of Tropical Medicine and Hygiene 55, 655-660.