Aerosol delivery to young children by pMDI-spacer: Is facemask design important?

Pediatric Allergy and Immunology

Volumn 16, Issue 4, 2005, Pages 348-353

  Esposito Festen, José ^a   Ates, Bahar ^a   Van Vliet, Frans ^b   Hop, Wim ^b   Tiddens, Harm ^a  

^a SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Aerosol; Facemask; Spacer; Wheeze; Young children

Indexed keywords

BUDESONIDE;

AEROSOL; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DAILY LIFE ACTIVITY; DRUG DELIVERY SYSTEM; FACE MASK; HUMAN; INFANT; METERED DOSE INHALER; NEBULIZER; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; WHEEZING;

ADMINISTRATION, INHALATION; AGE FACTORS; BRONCHODILATOR AGENTS; BUDESONIDE; COUGH; CROSS-OVER STUDIES; DYSPNEA; EQUIPMENT DESIGN; FEMALE; HUMANS; INFANT; INHALATION SPACERS; MALE; MASKS; METERED DOSE INHALERS; RESPIRATORY SOUNDS;

EID: 20944433835     PISSN: 09056157     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-3038.2005.00285.x     Document Type: Article

References (22)

1. CONNER WT, DOLOVICH MB, FRAME RA, NEWHOUSE MT. Reliable salbutamol administration in 6- to 36-month-old children by means of a metered dose inhaler and Aerochamber with mask. Pediatr Pulmonol 1989: 6: 263-267.
2. BISGAARD H. Aerosol treatment of young children. Eur Respir Rev 1994: 4: 15-20.
3. BISGAARD H, MUNCK SL, NIELSEN JP, PETERSEN W, OHLSSON SV. Inhaled budesonide for treatment of recurrent wheezing in early childhood. Lancet 1990: 336: 649-651.
4. BARRY PW, O'CALLAGHAN C. The effect of delay, multiple actuations and spacer static charge on the in vitro delivery of budesonide from the Nebuhaler. Br J Clin Pharmacol 1995: 40: 76-78.
5. O'CALLAGHAN C. Delivery systems: the science. Pediatr Pulmonol Suppl 1997: 15: 51-54.
6. EVERARD ML. Management of asthma in childhood. J Pharm Pharmacol 1997: 49 (Suppl. 3): 45-50.
7. JANSSENS HM, DEVADASON SG, HOP WC, LESOUEF PN, DE JONGSTE JC, TIDDENS HA. Variability of aerosol delivery via spacer devices in young asthmatic children in daily life. Eur Respir J 1999: 13: 787-791.
8. WILDHABER JH, DEVADASON SG, EBER E, et al. Effect of electrostatic charge, flow, delay and multiple actuations on the in vitro delivery of salbutamol from different small volume spacers for infants. Thorax 1996: 51: 985-988.
9. ILES R, LISTER P, EDMUNDS AT. Crying significantly reduces absorption of aerosolised drug in infants [see comments]. Arch Dis Child 1999: 81: 163-165.
10. EVERARD ML, CLARK AR, MILNER AD. Drug delivery from holding chambers with attached facemask. Arch Dis Child 1992: 67: 580-585.
11. JANSSENS HM, HEIJNEN, EMEW, de JONG VM, HOP WCJ, HOLLAND, WPJ, de JONGSTE JC, TIDDENS, HAWM. Aerosol delivery from spacers in wheezy infants: a daily life study. Eur Respir J 2000: 16: 850-856.
12. AMIRAV I, NEWHOUSE MT. Aerosol therapy with valved holding chambers in young children: importance of the facemask seal. Pediatrics 2001: 108: 389-94.
13. BISGAARD H. A metal aerosol holding chamber devised for young children with asthma. Eur Respir J 1995: 8: 856-860.
14. AMIRAV I, MANSOUR Y, MANDELBERG A, BAR-ILAN I, NEWHOUSE MT. Redesigned face mask improves "real life" aerosol delivery for Nebuchamber. Pediatr Pulmonol 2004: 37: 172-177.
15. AGERTOFT L, PEDERSEN S. Influence of spacer device on drug delivery to young children with asthma. Arch Dis Child 1994: 71: 217-9, discussion 219-220.
16. BISGAARD H, ANHOJ J, KLUG B, BERG E. A non-electrostatic spacer for aerosol delivery. Arch Dis Child 1995: 73: 226-230.
17. BOCCUTI L, CELANO M, GELLER RJ, PHILLIPS KM. Development of a scale to measure children's metered-dose inhaler and spacer technique. Ann All Asthma Immunol 1996: 77: 217-221.
18. EVERARD ML. Management of asthma in childhood. J Pharm Pharmacol 1997: 49 (Suppl. 3): 45-50.
19. EVERARD ML. Aerosol therapy past, present, and future: a clinician's perspective [In Process Citation]. Respir Care 2000: 45: 769-776.
20. TAL A, GOLAN H, GRAUER N, AVIRAM M, ALBIN D, QUASTEL MR. Deposition pattern of radiolabeled salbutamol inhaled from a metered - dose inhaler by means of a spacer with mask in young children with airway obstruction. J Pediatr 1996: 128: 479-484.
21. ESPOSITO-FESTEN JE, ATES B, VAN VLIET FJM, VERBRAAK AFM, DE JONGSTE JC, TIDDENS HAWM. Effect of a facemask leak on aerosol delivery from a pMDI-spacer system. J Aerosol Med 2004: 17: 1-6.
22. AMIRAV I, TIOSANO T, CHAMNY S, et al. Comparison of efficiency and preference of metal and plastic spacers in preschool children. Ann All Asthma Immunol 2004: 93: 249-252.