Unnoticed spread of integron-carrying enterobacteriaceae in intensive care units

Clinical Infectious Diseases

Volumn 41, Issue 1, 2005, Pages 1-9

  Nijssen, S ^a   Florijn, A ^b   Top, J ^a   Willems, R ^a   Fluit, A ^b   Bonten, M ^a,b  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE; AMOXICILLIN PLUS CLAVULANIC ACID; AMPICILLIN; CEFOTAXIME; CEFOXITIN; CEFPODOXIME; CEFTAZIDIME; CEPHALOSPORIN; CEPHALOSPORIN DERIVATIVE; CHLORAMPHENICOL; CIPROFLOXACIN; GENTAMICIN; INTEGRASE; KANAMYCIN; MEROPENEM; PIPERACILLIN; PIPERACILLIN PLUS TAZOBACTAM; QUINOLONE DERIVATIVE; SPECTINOMYCIN; STREPTOMYCIN; TICARCILLIN; TOBRAMYCIN; TRIMETHOPRIM; VANCOMYCIN;

ADULT; AGED; AMPLIFIED FRAGMENT LENGTH POLYMORPHISM; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL TRANSMISSION; BACTERIUM ISOLATE; CITROBACTER FREUNDII; CONTROLLED STUDY; DNA SEQUENCE; ENTEROBACTER CLOACAE; ENTEROBACTERIACEAE; ESCHERICHIA COLI; FEMALE; GENE TRANSFER; GENOTYPE; HOSPITAL INFECTION; HUMAN; HUMAN TISSUE; INTEGRON; INTENSIVE CARE UNIT; KLEBSIELLA OXYTOCA; KLEBSIELLA PNEUMONIAE; MAJOR CLINICAL STUDY; MALE; PANTOEA AGGLOMERANS; POLYMERASE CHAIN REACTION; PREVALENCE; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK FACTOR;

ADULT; AGED; ANTI-BACTERIAL AGENTS; CEPHALOSPORINS; CROSS INFECTION; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ENTEROBACTERIACEAE; ENTEROBACTERIACEAE INFECTIONS; FEMALE; GENE TRANSFER, HORIZONTAL; HUMANS; INTEGRASES; INTEGRONS; INTENSIVE CARE UNITS; MALE; MICROBIAL SENSITIVITY TESTS; MIDDLE AGED; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; PREVALENCE; SEQUENCE ANALYSIS, DNA;

EID: 20844449257     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1086/430711     Document Type: Article

References (22)

1. Kollef MH, Fraser VJ. Antibiotic resistance in the intensive care unit. Ann Intern Med 2001; 134:298-314.
2. Lipsitch M, Samore MH. Antimicrobial use and antimicrobial resistance: a population perspective. Emerg Infect Dis 2002; 8:347-54.
3. Martinez-Freijo P, Fluit AC, Schmitz FJ, et al. Class I integrons in gram-negative isolates from different European hospitals and association with decreased susceptibility to multiple antibiotic compounds. J Antimicrob Chemother 1998; 42:689-96.
4. Hall RM, Collis CM. Antibiotic resistance in gram-negative bacteria: the role of gene cassettes and integrons. Drug Resist Updat 1998; 109-19.
5. Rowe-Magnus DA, Mazel D. Resistance gene capture. Curr Opin Microbiol 1999; 2:483-8.
6. Leverstein-van Hall MA, Box AT, Blok HE, et al. Evidence of extensive interspecies transfer of integron-mediated antimicrobial resistance genes among multidrug-resistant Enterobacteriaceae in a clinical setting. J Infect Dis 2002; 186:49-56.
7. Gruteke P, Goessens W, Van Gils J, et al. Patterns of resistance associated with integrons, the extended-spectrum β-lactamase SHV-5 gene, and a multidrug efflux pump of Klebsiella pneumoniae causing a nosocomial outbreak. J Clin Microbiol 2003; 41:1161-6.
8. Levesque C, Piche L, Larose C, Roy PH. PCR mapping of integrons reveals several novel combinations of resistance genes. Antimicrob Agents Chemother 1995; 39:185-91.
9. van Belkum A, Goessens W, van der Schee C, et al. Rapid emergence of ciprofloxacin-resistant Enterobacteriaceae containing multiple gentamicin resistance-associated integrons in a Dutch hospital. Emerg Infect Dis 2001; 7:862-71.
10. NCCLS. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Approved Standard M7-A4. Wayne, PA: NCCLS, 1999.
11. Florijn A, Nijssen S, Schmitz FJ, Verhoef J, Fluit AC. Comparison of E test and double disk diffusion test for detection of extended spectrum β-lactamases. Eur J Clin Microbiol Infect Dis 2002; 21:241-3.
12. Leverstein-van Hall MA, Paauw A, Box AT, et al. Presence of integron-associated resistance in the community is widespread and contributes to multidrug resistance in the hospital. J Clin Microbiol 2002; 40: 3038-40.
13. Peters ED, Leverstein-van Hall MA, Box AT, Verhoef J, Fluit AC. Novel gene cassettes and integrons. Antimicrob Agents Chemother 2001; 45: 2961-4.
14. Willems RJ, Top J, van den Braak N, et al. Host specificity of vancomycin-resistant Enterococcus faecium. J Infect Dis 2000; 182:816-23.
15. Nandi S, Maurer JJ, Hofacre C, Summers AO. Gram-positive bacteria are a major reservoir of class 1 antibiotic resistance integrons in poultry litter. Proc Natl Acad Sci USA 2004; 101:7118-22.
16. Hayden MK. Insights into the epidemiology and control of infection with vancomycin-resistant Enterococci. Clin Infect Dis 2000; 31: 1058-65.
17. Baquero F, Coque TM, Canton R. Allodemics. Lancet Infect Dis 2002; 2:591-2.
18. Gassama A, Aidara-Kane A, Chainier D, Denis F, Ploy MC. Integron-associated antibiotic resistance in enteroaggregative and enteroinvasive Escherichia coli. Microb Drug Resist 2004; 10:27-30.
19. Mathai E, Grape M, Kronvall G. Integrons and multidrug resistance among Escherichia coli causing community-acquired urinary tract infection in southern India. APMIS 2004; 112:159-64.
20. Guerra B, Junker E, Schroeter A, et al. Phenotypic and genotypic characterization of antimicrobial resistance in German Escherichia coli isolates from cattle, swine and poultry. J Antimicrob Chemother 2003; 52:489-92.
21. Gebreyes WA, Thakur S, Davies PR, Funk JA, Altier C. Trends in antimicrobial resistance, phage types and integrons among Salmonella serotypes from pigs, 1997-2000. J Antimicrob Chemother 2004; 53: 997-1003.
22. Roe MT, Vega E, Pillai SD. Antimicrobial resistance markers of class 1 and class 2 integron-bearing Escherichia coli from irrigation water and sediments. Emerg Infect Dis 2003; 9:822-6.