Synthesis, characterization, and pharmacokinetic evaluation of a potential MRI contrast agent containing two paramagnetic centers with albumin binding affinity

Chemistry - A European Journal

Volumn 11, Issue 10, 2005, Pages 3077-3086

  Parac Vogt, Tatjana N ^a   Kimpe, Kristot ^a   Laurent, Sophie ^b   Elst, Luce Vander ^b   Burtea, Carmen ^b   Chen, Feng ^c   Muller, Robert N ^b   Ni, Yicheng ^c   Verbruggen, Alfons ^d   Binnemans, Koen ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY OF MONS   (Belgium)

^c UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^d Department of Pharmaceutical and Pharmacological Sciences   (Belgium)

Author keywords

Gadolinium; Imaging agents; Lanthanides; NMR spectroscopy; Rare earths

Indexed keywords

BINDING ENERGY; CHELATION; FOURIER TRANSFORM INFRARED SPECTROSCOPY; GADOLINIUM; IMAGING TECHNIQUES; MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PARAMAGNETIC MATERIALS; PROTEINS; RARE EARTH ELEMENTS; RARE EARTHS; SPECTROMETERS; SYNTHESIS (CHEMICAL);

BINDING AFFINITY; HUMAN SERUM ALBUMIN (HSA); IMAGING AGENTS; MOIETIES; PARAMAGNETIC CENTERS;

PHARMACOKINETICS;

CONTRAST MEDIUM; GADOLINIUM; LIGAND; SERUM ALBUMIN; WATER; ZINC;

ANIMAL; ARTICLE; CHEMICAL STRUCTURE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; HUMAN; NECROSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; RAT; SYNTHESIS; TIME; WISTAR RAT;

ANIMALS; CONTRAST MEDIA; GADOLINIUM; HUMANS; LIGANDS; MAGNETIC RESONANCE IMAGING; MOLECULAR STRUCTURE; NECROSIS; RATS; RATS, WISTAR; SERUM ALBUMIN; TIME FACTORS; WATER; ZINC;

EID: 20844440891     PISSN: 09476539     EISSN: None     Source Type: Journal    
DOI: 10.1002/chem.200401207     Document Type: Article

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