Parathyroid hormone-related protein-mediated responses in pulmonary arteries and veins of newborn lambs

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 289, Issue 1 33-1, 2005, Pages

  Gao, Yuansheng ^a,b,c   Raj, J Usha ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Peking University Health Science Center   (China)

^c HARBOR UCLA MEDICAL CENTER   (United States)

Author keywords

cAMP; Perinatal lungs; Potassium channel; Vasodilation

Indexed keywords

4 AMINOPYRIDINE; 9 (TETRAHYDRO 2 FURYL)ADENINE; ADENYLATE CYCLASE; CALCIUM ACTIVATED POTASSIUM CHANNEL; CHARYBDOTOXIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTHELIN 1; PARATHYROID HORMONE RELATED PROTEIN; PHOSPHODIESTERASE INHIBITOR;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; LAMB; NONHUMAN; PRIORITY JOURNAL; PULMONARY ARTERY; PULMONARY VEIN; RADIOIMMUNOASSAY; SHEEP; VASCULAR ENDOTHELIUM; VASOMOTOR REFLEX;

ADENINE; ADENYLATE CYCLASE; ANIMALS; ANIMALS, NEWBORN; CHARYBDOTOXIN; CYCLIC AMP; ENDOTHELIN-1; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; LUNG; MUSCLE, SMOOTH, VASCULAR; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; ORGAN CULTURE TECHNIQUES; PARATHYROID HORMONE-RELATED PROTEIN; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; POTASSIUM CHANNELS, VOLTAGE-GATED; PULMONARY ARTERY; PULMONARY VEINS; SHEEP, DOMESTIC; VASODILATION;

EID: 20844440295     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.00411.2004     Document Type: Article

References (57)

1. 2-adrenoceptor receptor overexpression in the developing mouse heart: evidence for targeted modulation of ion channels. J Physiol 516: 19-30, 1999.
2. Barman SA. Role of calcium-activated-potassium channels and cyclic nucleotides on pulmonary vasoreactivity to serotonin. Am J Physiol Lung Cell Mol Physiol 273: L142-L147, 1997.
3. Barman SA, Zhu S, Han G, and White RE. cAMP activates BKCa channels in pulmonary arterial smooth muscle via cGMP-dependent protein kinase. Am J Physiol Lung Cell Mol Physiol 284: L1004-L1011, 2003.
4. Bradford MM. A rapid method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding. Anal Chem 72: 249-254, 1973.
5. Cardoso WV. Molecular regulation of lung development. Annu Rev Physiol 63: 471-494, 2001.
6. Degenhardt H, Jansen J, Schulz R, Sedding D, Braun-Dullaeus R, and Schluter KD. Mechano-sensitive release of parathyroid hormone-related peptide from coronary endothelial cells. Am J Physiol Heart Circ Physiol 283: H1489-H1496, 2002.
7. Everhart-Caye M, Inzucchi SE, Guinness-Henry J, Mitnick MA, and Stewart AF. Parathyroid hormone (PTH)-related protein(1-36) is equipotent to PTH(1-34) in humans. J Clin Endocrinol Metab 81: 199-208, 1996.
8. Fineman JR, Soifer SJ, and Heymann MA. Regulation of pulmonary vascular tone in the perinatal period. Annu Rev Physiol 57: 115-134, 1995.
9. Funk JL, Migliati E, Chen G, Wei H, Wilson J, Downey KJ, Mullarky PJ, Coull BM, McDonagh PF, and Ritter LS. Parathyroid hormone-related protein induction in focal stroke: a neuroprotective vascular peptide. Am J Physiol Regul Integr Comp Physiol 284: R1021-R1030, 2003.
10. Furchgott RF and Vanhoutte PM. Endothelium-derived relaxing and contracting factors. FASEB J 3: 2007-2018, 1989.
11. Gao Y and Raj JU. Effects of SQ 22536, an adenylyl cyclase inhibitor, on isoproterenol-induced cAMP elevation and relaxation in newborn ovine pulmonary veins. Eur J Pharmacol 436: 227-233, 2002.
12. Gao Y and Raj JU. Role of veins in regulation of the pulmonary circulation. Am J Physiol Lung Cell Mol Physiol 288: L213-L226, 2005.
13. Gao Y, Tolsa JF, and Raj JU. Heterogeneity in endothelium-derived nitric oxide-mediated relaxation of different sized pulmonary arteries of newborn lambs. Pediatr Res 44: 723-729, 1998.
14. 2 cause greater relaxations in pulmonary veins than in arteries of newborn lambs. J Appl Physiol 81: 2534-2539, 1996.
15. Gao Y, Zhou H, and Raj JU. Endothelium-derived nitric oxide plays a larger role in pulmonary veins than in arteries in newborn lambs. Circ Res 76: 559-565, 1995.
16. Haslam RJ, Davidson MM, and Desjardins JV. Inhibition of adenylate cyclase by adenosine analogues in preparations of broken and intact human platelets. Evidence for the unidirectional control of platelet function by cyclic AMP. Biochem J 176: 83-95, 1978.
17. 2+ signal transduction pathways. J Biol Chem 271: 33382-33389, 1996.
18. Ishikawa M, Ouchi Y, Han SZ, Akishita M, Kozaki K, Toba K, Namiki A, Yamaguchi T, and Orimo H. Parathyroid hormone-related protein reduces cytosolic free Ca2+ level and tension in rat aortic smooth muscle. Eur J Pharmacol 269: 311-317, 1994.
19. Jiang H, Halayko AJ, Rao K, Cunningham P, and Stephens NL. Normalization of force generated by canine airway smooth muscles. Am J Physiol Lung Cell Mol Physiol 260: L522-L529, 1991.
20. Johnson RA, De'saubry L, Bianchi G, Shoshani I, Lyons E Jr, Taussigi R, Watson PA, Cali JJ, Krupinski J, Pieroni JP, and Iyengar R. Isozyme-dependent sensitivity of adenylyl cyclases to P-site-mediated inhibition by adenine nucleosides and nucleoside 3′-polyphosphates. J Biol Chem 272: 8962-8966, 1997.
21. Kalinowski L, Dobrucki LW, and Malinski T. Nitric oxide as a second messenger in parathyroid hormone-related protein signaling. J Endocrinol 170: 433-440, 2001.
22. Liu YA, Theis JGW, and Coceani F. Contractile and relaxing mechanisms in pulmonary resistance arteries of the preterm fetal lamb. Biol Neonate 77: 253-260, 2000.
23. Maeda S, Wu S, Juppner H, Green J, Aragay AM, Fagin JA, and Clemens TL. Cell-specific signal transduction of parathyroid hormone (PTH)-related protein through stably expressed recombinant PTH/PTHrP receptors in vascular smooth muscle cells. Endocrinology 137: 3154-3162, 1996.
24. Massfelder T, Stewart AF, Endlich K, Soifer N, Judes C, and Helwig JJ. Parathyroid hormone-related protein detection and interaction with NO and cyclic AMP in the renovascular system. Kidney Int 50: 1591-1603, 1996.
25. Meyer RBJ and Miller JP. Analogs of cyclic AMP and cyclic GMP: general methods of synthesis and the relationship of structure to enzymic activity. Life Sci 14: 1019-1040, 1974.
26. Michelakis ED, Reeve HL, Huang JM, Tolarova S, Nelson DP, Weir EK, and Archer SL. Potassium channel diversity in vascular smooth muscle cells. Can J Physiol Pharmacol 75: 889-897, 1997.
27. Michelakis ED, Weir EK, Wu X, Nsair A, Waite R, Hashimoto K, Puttagunta L, Knaus HG, and Archer SL. Potassium channels regulate tone in rat pulmonary veins. Am J Physiol Lung Cell Mol Physiol 280: L1138-L1147, 2001.
28. Mizuno R, Ono N, and Ohhashi T. Parathyroid hormone-related protein-(1-34) inhibits intrinsic pump activity of isolated murine lymph vessels. Am J Physiol Heart Circ Physiol 281: H60-H66, 2001.
29. Mok LL, Ajiwe E, Martin TJ, Thompson JC, and Cooper CW. Parathyroid hormone-related protein relaxes rat gastric smooth muscle and shows cross-desensitization with parathyroid hormone. J Bone Miner Res 4: 433-439, 1989.
30. Nakayama T, Ohtsuru A, Enomoto H, Namba H, Ozeki S, Shibata Y, Yokota T, Nobuyoshi M, Ito M, and Sekine I. Coronary atherosclerotic smooth muscle cells over-express human parathyroid hormone-related peptides. Biochem Biophys Res Commun 200: 1028-1035, 1994.
31. Nelson MT and Quayle JM. Physiological roles and properties of potassium channels in arterial smooth muscle. Am J Physiol Cell Physiol 268: C799-C822, 1995.
32. Noda M, Katoh T, Takuwa N, Kumada M, Kurokawa K, and Takuwa Y. Synergistic stimulation of parathyroid hormone-related peptide gene expression by mechanical stretch and angiotensin II in rat aortic smooth muscle cells. J Biol Chem 269: 17911-17917, 1994.
33. Ogino K, Burkhoff D, and Bilezikian JP. The hemodynamic basis for the cardiac effects of parathyroid hormone (PTH) and PTH-related protein. Endocrinology 136: 3024-3030, 1995.
34. Okogbule-Wonodi AC, Ibe BO, Yue BW, Hsu S, and Raj JU. Phosphodiesterase activity in intrapulmonary arteries and veins of perinatal lambs. Mol Genet Metab 65: 229-237, 1998.
35. Ozeki S, Ohtsuru A, Seto S, Takeshita S, Yano H, Nakayama T, Ito M, Yokota T, Nobuyoshi M, Segre GV, Yamashita S, and Yano K. Evidence that implicates the parathyroid hormone-related peptide in vascular stenosis. Increased gene expression in the intima of injured carotid arteries and human restenotic coronary lesions. Arterioscler Thromb Vasc Biol 16: 565-575, 1996.
36. Patel TB, Du Z, Pierre S, Cartin L, and Scholich K. Molecular biological approaches to unravel adenylyl cyclase signaling and function. Gene 269: 13-25, 2001.
37. Philbrick WM, Wysolmerski JJ, Galbraith S, Holt E, Orloff JJ, Yang KH, Vasavada RC, Weir EC, Broadus AE, and Stewart AF. Defining the roles of parathyroid hormone-related protein in normal physiology. Physiol Rev 76: 127-173, 1996.
38. Pirola CJ, Wang HM, Kamyar A, Wu S, Enomoto H, Sharifi B, Forrester JS, Clemens TL, and Fagin JA. Angiotensin II regulates parathyroid hormone-related protein expression in cultured rat aortic smooth muscle cells through transcriptional and post-transcriptional mechanisms. J Biol Chem 268: 1987-1994, 1993.
39. Pirola CJ, Wang HM, Strgacich MI, Kamyar A, Cercek B, Forrester JS, Clemens TL, and Fagin JA. Mechanical stimuli induce vascular parathyroid hormone-related protein gene expression in vivo and in vitro. Endocrinology 134: 2230-2236, 1994.
40. Raj JU and Chen P. Microvascular pressures measured by micropuncture in isolated perfused lamb lungs. J Appl Physiol 61: 2194-2201, 1986.
41. Raj JU and Chen P. Effect of edema on segmental vascular resistance in isolated lamb lungs determined by micropuncture. Circ Res 61: 236-243, 1987.
42. Ratcliffe WA, Norbury S, Stott RA, Heath DA, and Ratcliffe JG. Immunoreactivity of plasma parathyrin-related peptide: three region-specific radioimmunoassays and a two-site immunoradiometric assay compared. Clin Chem 37: 1781-1787, 1991.
43. Reeve HL, Archer SL, and Weir EK. Ion channels in the pulmonary vasculature. Pulm Pharmacol Ther 10: 243-252, 1997.
44. Rich TC, Fagan KA, Nakata H, Schaack J, Cooper DM, and Karpen JW. Cyclic nucleotide-gated channels co-localize with adenylyl cyclase in regions of restricted cAMP diffusion. J Gen Physiol 116: 147-61, 2000.
45. Rudolph AM. Fetal and neonatal pulmonary circulation. Annu Rev Physiol 41: 383-395, 1979.
46. Shenberger JS, Shew RL, Johnson DE, and Kannan MS. Relaxation of porcine tracheal smooth muscle by parathyroid hormone-related protein. Respir Physiol 107: 59-66, 1997.
47. Shew RL, Yee JA, Kliewer DB, Keflemariam YJ, and McNeill DL. Parathyroid hormone-related protein inhibits stimulated uterine contraction in vitro. J Bone Miner Res 6: 955-959, 1991.
48. Sutliff RL, Weber CS, Qian J, Miller ML, Clemens TL, and Paul RJ. Vasorelaxant properties of parathyroid hormone-related protein in the mouse: evidence for endothelium involvement independent of nitric oxide formation. Endocrinology 140: 2077-2083, 1999.
49. Thiebaud D, Janisch S, Koelbl H, Hanzal E, Jacquet AF, Leodolter S, Burckhardt P, and Pecherstorfer M. Direct evidence of a parathyroid related protein gradient between the mother and the newborn in humans. Bone Miner 23: 213-221, 1993.
50. Thompson WJ. Cyclic nucleotide phosphodiesterases: pharmacology, biochemistry and function. Pharmacol Ther 51: 13-33, 1991.
51. Toga H, Ibe BO, and Raj JU. In vitro responses of ovine intrapulmonary arteries and veins to endothelin-1. Am J Physiol Lung Cell Mol Physiol 263: L15-L21, 1992.
52. Toga H, Raj JU, Hillyard R, Ku B, and Anderson J. Endothelin effects in isolated, perfused lamb lungs: role of cyclooxygenase inhibition and vasomotor tone. Am J Physiol Heart Circ Physiol 261: H443-H450, 1991.
53. Torday JS and Rehan VK. Deconvoluting lung evolution using functional/comparative genomics. Am J Respir Cell Mol Biol 31: 8-12, 2004.
54. Torday JS, Sanchez-Esteban J, and Rubin LP. Paracrine mediators of mechanotransduction in lung development. Am J Med Sci 316: 205-208, 1998.
55. Torday JS, Sun H, Wang L, Torres E, Sunday ME, and Rubin LP. Leptin mediates the parathyroid hormone-related protein paracrine stimulation of fetal lung maturation. Am J Physiol Lung Cell Mol Physiol 282: L405-L410, 2002.
56. Yamamoto M, Harm SC, Grasser WA, and Thiede MA. Parathyroid hormone-related protein in the rat urinary bladder: a smooth muscle relaxant produced locally in response to mechanical stretch. Proc Natl Acad Sci USA 89: 5326-5330, 1992.
57. Zhou HL, Newsholme SJ, and Torphy TJ. Agonist-related differences in the relationship between cAMP content and protein kinase activity in canine trachealis. J Pharmacol Exp Ther 261: 1260-1267, 1992.