TGF-α perturbs surfactant homeostasis in vivo

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 289, Issue 1 33-1, 2005, Pages

  Ikegami, Machiko ^a,c   Le Cras, Timothy D ^a   Hardie, William D ^a   Stahlman, Mildred T ^b   Whitsett, Jeffrey A ^a   Korfhagen, Thomas R ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Acute respiratory distress syndrome; Bronchopulmonary dysplasia; Pulmonary fibrosis; Surface activity of surfactant

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; MESSENGER RNA; PHOSPHATIDYLCHOLINE; PHOSPHOLIPID; PROTEIN; SURFACTANT; TRANSFORMING GROWTH FACTOR ALPHA;

ADULT RESPIRATORY DISTRESS SYNDROME; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CONTROLLED STUDY; HOMEOSTASIS; LUNG DYSPLASIA; LUNG LAVAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN METABOLISM; RESPIRATORY EPITHELIUM; SIGNAL TRANSDUCTION; SURFACE TENSION;

ANIMALS; CELLS, CULTURED; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; HOMEOSTASIS; LUNG; MICE; MICE, TRANSGENIC; PHOSPHATIDYLCHOLINES; PULMONARY SURFACTANT-ASSOCIATED PROTEINS; RECEPTOR, EPIDERMAL GROWTH FACTOR; TRANSFORMING GROWTH FACTOR ALPHA;

EID: 20844438139     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.00407.2004     Document Type: Article

References (53)

1. Akira S. IL-6 regulated transcription factors. Int J Biochem 29: 1401-1418, 1997.
2. Bachurski CJ, Ross GF, Ikegami M, Kramer BW, and Jobe AH. Intra-amniotic endotoxin increases pulmonary surfactant components and induces SP-B processing in fetal sheep. Am J Physiol Lung Cell Mol Physiol 280: L279-L285, 2001.
3. Bartlett GR. Phosphorus assay in column chromatography. J Biol Chem 234: 466-468, 1959.
4. Chesnutt AN, Kheradmand F, Folkesson HG, Alberts M, and Matthay MA. Soluble transforming growth factor-α is present in the pulmonary edema fluid of patients with acute lung injury. Chest 111: 652-656, 1997.
5. Chess PR, Ryan RM, and Finkelstein JN. H441 pulmonary epithelial cell mutagenic effects and signaling pathways in response to HGF and TGF-α. Exp Lung Res 24: 27-39, 1998.
6. Clark JC, Wert SE, Bachurski CJ, Stahlman MT, Stripp BR, Weaver TE, and Whitsett JA. Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice. Proc Natl Acad Sci USA 92: 7794-7798, 1995.
7. Clement A, Masliah J, Housset B, Just J, Garcia J, Grimfeld A, and Tournier G. Decreased phosphatidylcholine content in bronchoalveolar lavage fluids of children with bronchopulmonary dysplasia: a preliminary investigation. Pediatr Pulmonol 3: 67-70, 1987.
8. Coalson JJ. Pathology of chronic lung disease of early infancy. In: Chronic Lung Disease in Early Infancy, edited by Bland RD and Coalson JJ. New York: Dekker, 2000, p. 85-124.
9. Coalson JJ, King RJ, Yang FM, Winter V, Whitsett JA, Delemos RA, and Seidner SR, SP-A deficiency in primate model of bronchopulmonary dysplasia with infection: in situ mRNA and immunostains. Am J Respir Crit Care Med 151: 854-866, 1995.
10. Dobbs LG. Isolation and culture of alveolar type II cells. Am J Physiol Lung Cell Mol Physiol 258: L134-L147, 1990.
11. Epaud R, Ikegami M, Whitsett JA, Jobe AH, Weaver TE, and Akinbi HT. Surfactant protein B inhibits endotoxin-induced lung inflammation. Am J Respir Cell Mol Biol 28: 373-378, 2003.
12. Fernandes A, Hamburger AW, and Gerwin BI. ErbB-2 kinase is required for constitutive stat 3 activation in malignant human lung epithelial cells. Int J Cancer 83: 564-570, 1999.
13. Geiser T. Mechanisms of alveolar epithelial repair in acute lung injury-a translational approach. Swiss Med Wkly 133: 586-590, 2003.
14. Greene KE, Wright JR, Steinberg KP, Ruzinski JT, Caldwell E, Wong WB, Hull W, Whitsett JA, Akino T, Kuroki Y, Nagae H, Hudson LD, and Martin TR. Serial changes in surfactant-associated proteins in lung and serum before and after onset of ARDS. Am J Respir Crit Care Med 160: 1843-1850, 1999.
15. Gregory TJ, Longmore WJ, Moxley MA, Whitsett JA, Reed CR, Fowler AA III, Hudson LD, Maunder RJ, Crim C, and Hyers TM. Surfactant chemical composition and biophysical activity in acute respiratory distress syndrome. J Clin Invest 88: 1976-1981, 1991.
16. Hardie WD, Kerlakian CB, Bruno MD, Huelsman KM, Wert SE, Glasser SW, Whitsett JA, and Korfhagen TR. Reversal of lung lesions in transgenic transforming growth factor α mice by expression of mutant epidermal growth factor receptor. Am J Respir Cell Mol Biol 15: 499-508, 1996.
17. Hardie WD, Le Cras TD, Jiang K, Tichelaar JW, Azhar M, and Korfhagen T. Conditional expression of transforming growth factor-α in adult mouse lung causes pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 286: L741-L749, 2004.
18. Hardie WD, Piljan-Gentle A, Dunlavy MR, Ikegami M, and Korfhagen TR. Dose-dependent lung remodeling in transgenic mice expressing transforming growth factor-α. Am J Physiol Lung Cell Mol Physiol 281: L1088-L1094, 2001.
19. Hussain NA, Siddiqui NH, and Stocker JR. Pathology of arrested acinar development in postsurfactant bronchopulmonary dysplasia. Hum Pathol 29: 710-717, 1998.
20. Ikegami M, Ueda T, Hull W, Whitsett JA, Mulligan RC, Dranoff G, and Jobe AH. Surfactant metabolism in transgenic mice after granulocyte macrophage-colony stimulating factor ablation. Am J Physiol Lung Cell Mol Physiol 270: L650-L658, 1996.
21. Ikegami M, Weaver TE, Conkright JJ, Sly PD, Ross GF, Whitsett JA, and Glasser SW. Deficiency of SP-B reveals protective role of SP-C during oxygen lung injury. J Appl Physiol 92: 519-526, 2002.
22. Ikegami M, Whitsett JA, Jobe AH, Ross G, Fisher J, and Korfhagen T. Surfactant metabolism in SP-D gene ablated mice. Am J Physiol Lung Cell Mol Physiol 279: L468-L476, 2000.
23. Kazzi SN, Schurch S, McLaughlin KL, Romero R, and Janisse J. Surfactant phospholipids and surface activity among preterm infants with respiratory distress syndrome who develop bronchopulmonary dysplasia. Acta Paediatr 89: 1218-1225, 2000.
24. Kheradmand F, Folkesson HG, Shum L, Derynk R, Pytela R, and Matthay MA. Transforming growth factor-α enhances alveolar epithelial cell repair in a new in vitro model. Am J Physiol Lung Cell Mol Physiol 267: L728-L738, 1994.
25. King RJ, Coalson JJ, Delemos RA, Gerstmann DR, and Seidner SR. Surfactant protein-A deficiency in a primate model of bronchopulmonary dysplasia. Am J Respir Crit Care Med 151: 1989-1997, 1995.
26. Korfhagen TR, Swantz RJ, Wert SE, McCarty JM, Kerlakian CB, Glasser SW, and Whitsett JA. Respiratory epithelial cell expression of human transforming growth factor-α induces lung fibrosis in transgenic mice. J Clin Invest 93: 1691-1699, 1994.
27. Le Cras TD, Hardie WD, Fagan K, Whitsett JA, and Korfhagen TR. Disrupted pulmonary vascular development and pulmonary hypertension in transgenic mice overexpressing transforming growth factor-α. Am J Physiol Lung Cell Mol Physiol 285: L1046-L1054, 2003.
28. Liu JY, Morris GF, Lei WH, Corti M, and Brody AR. Up-regulated expression of transforming growth factor-α in the bronchiolar-alveolar duct regions of asbestos-exposed rats. Am J Pathol 149: 205-217, 1996.
29. Loring SH, Drazen JM, Smith JC, and Hoppin FG Jr. Vagal stimulation and aerosol histamine increase hysteresis of lung recoil. J Appl Physiol 51: 477-484, 1981.
30. Madtes DK, Busby HK, Strandjord TP, and Clark JG. Expression of transforming growth factor-α and epidermal growth factor receptor is increased following bleomycin-induced lung injury in rats. Am J Respir Cell Mol Biol 11: 540-551, 1994.
31. Madtes DK, Rubenfeld G, Klima LD, Milberg JA, Steinberg KP, Martin TR, Raghu G, Hudson LD, and Clark JG. Elevated transforming growth factor-α levels in bronchoalveolar lavage fluid of patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 158: 424-430, 1998.
32. Mason RJ, Nellenbogen J, and Clements JA. Isolation of disaturated phosphatidylcholine with osmium tetroxide. J Lipid Res 17: 281-284, 1976.
33. McCormack FX and Whitsett JA. The pulmonary collectins, SP-A and SP-D, orchestrate innate immunity in the lung. J Clin Invest 109: 707-712, 2002.
34. Melton KR, Nesslein LL, Ikegami M, Tichelaar JW, Clark JC, Whitsett JA, and Weaver TE. SP-B deficiency causes respiratory failure in adult mice. Am J Physiol Lung Cell Mol Physiol 285: L543-L549, 2003.
35. Nogee LM. Surfactant protein-B deficiency. Chest 111: 129S-135S, 1997.
36. Northway WH Jr, Rosan RC, and Porter DY. Pulmonary disease following respirator therapy of hyaline-membrane disease. Bronchopulmonary dysplasia. N Engl J Med 276: 357-368, 1967.
37. Obladen M. Alterations in surfactant composition. In: Bronchopulmonary Dysplasia, edited by Merritt TA, Northway WH, and Boynton BR. Cambridge, MA: Blackwell Scientific, 1988, p. 131-141.
38. Raaberg L, Nexo E, Buckley S, Luo W, Snead ML, and Warburton D. Epidermal growth factor transcription, translation, and signal transduction by rat type II pneumocytes in culture. Am J Respir Cell Mol Biol 6: 44-49, 1992.
39. Rice WR, Conkright JJ, Na CL, Ikegami M, Shannon JM, and Weaver TE. Maintenance of the mouse type II cell phenotype in vitro. Am J Physiol Lung Cell Mol Physiol 283: L256-L264, 2002.
40. Ryan RM, Mineo-Kuhn MM, Kramer CM, and Finkelstein JN. Growth factors alter neonatal type II alveolar epithelial cell proliferation. Am J Physiol Lung Cell Mol Physiol 266: L17-L22, 1994.
41. Scherle WF. A simple method of volumetry of organs in quantitative stereology. Mikroskopie 26: 57-60, 1970.
42. Schoel M, Schurch S, and Goerke J. The captive bubble method for the evaluation of pulmonary surfactant: surface tension, area, and volume calculations. Biochim Biophys Acta 1200: 281-290, 1994.
43. Schroeder MD, Rose-Hellekant TA, Sandgren EP, and Schuler LA. Dysregulation of mammary Stats 1, 3 and 5 and PRL receptors by overexpression of TGF-α. Mol Cell Endocrinol 175: 173-183, 2001.
44. Seeger W, Pison U, Buchhorn R, Obertacke U, and Joka T. Surfactant abnormalities and adult respiratory failure. Lung 168, Suppl: 891-902, 1990.
45. Seidner SR, Jobe AH, Coalson JJ, and Ikegami M. Abnormal surfactant metabolism and function in preterm ventilated baboons. Am J Respir Crit Care Med 158: 1982-1989, 1998.
46. Stahlman MT, Orth DN, and Gray ME. Immunocytochemical localization of epidermal growth factor in the developing human respiratory system and in acute and chronic lung disease in the neonate. Lab Invest 60: 539-547, 1989.
47. Stone KC, Mercer RR, Gehr P, Stockstill B, and Crapo JD. Allometric relationships of cell numbers and size in the mammalian lung. Am J Respir Cell Mol Biol 6: 235-243, 1992.
48. Strandjord TP, Clark JG, Guralnick DE, and Madtes DK. Immunolocalization of transforming growth factor-α, epidermal growth factor (EGF), and EGF-receptor in normal and injured developing human lung. Pediatr Res 38: 851-856, 1995.
49. Tichelaar JW, Lu W, and Whitsett JA. Conditional expression of fibroblast growth factor-7 in the developing and mature lung. J Biol Chem 275: 11858-11864, 2000.
50. Tokieda K, Whitsett JA, Bachurski C, Wert SE, Hull WM, and Iwamoto HS. SP-B deficient mice are susceptible to hyperoxic lung injury. Am J Respir Cell Mol Biol 21: 463-472, 1999.
51. Vivekananda J, Lin A, Coalson JJ, and King RJ. Acute inflammatory injury in the lung precipitated by oxidant stress induces fibroblasts to synthesize and release transforming growth factor-α. J Biol Chem 269: 25057-25061, 1994.
52. Waheed S, D'Angio CT, Wagner CL, Madtes DK, Finkelstein JN, Paxhia A, and Ryan RM. Transforming growth factor α (TGFα) is increased during hyperoxia and fibrosis. Exp Lung Res 28: 361-372, 2002.
53. Zhou L, Lim L, Costa RH, and Whitsett JA. Thyroid transcription factor-1, hepatocyte nuclear factor-3 β, surfactant protein B, C, and Clara cell secretory protein in developing mouse lung. J Histochem Cytochem 44: 1183-1193, 1996.