Deferoxamine as a chelator for 67Ga in the preparation of antibody conjugates

Nuclear Medicine and Biology

Volumn 32, Issue 5, 2005, Pages 513-519

  Govindan, Serengulam V ^a   Michel, Rosana B ^b   Griffiths, Gary L ^a   Goldenberg, David M ^b   Mattes, M Jules ^b  

^a IMMUNOMEDICS INC   (United States)

^b CENTER FOR MOLECULAR MEDICINE AND IMMUNOLOGY   (United States)

Author keywords

67Ga; Auger electron emitter; Cytotoxicity in vitro; Deferoxamine; Radiometal chelators

Indexed keywords

1,4,7 TRIAZACYCLONONANE 1,4,7 TRIACETIC ACID; ACETIC ACID DERIVATIVE; ANTIBODY; ANTIBODY CONJUGATE; BUFFER; CALCIUM; CD74 ANTIBODY; CHELATING AGENT; D 9533; DEFEROXAMINE; DIVALENT CATION; GALLIUM 67; MAGNESIUM; THIOL DERIVATIVE; UNCLASSIFIED DRUG; GALLIUM;

ARTICLE; CATABOLISM; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG CONJUGATION; DRUG STABILITY; HALF LIFE TIME; HUMAN; HUMAN CELL; INTERNALIZATION; ISOTOPE LABELING; STATISTICAL SIGNIFICANCE; TECHNIQUE; CHEMISTRY; RADIOIMMUNOTHERAPY; TUMOR CELL LINE;

CELL LINE, TUMOR; CHELATING AGENTS; DEFEROXAMINE; GALLIUM RADIOISOTOPES; HUMANS; IMMUNOCONJUGATES; ISOTOPE LABELING; RADIOIMMUNOTHERAPY;

EID: 20744458436     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2005.04.009     Document Type: Article

References (31)

1. S.V. Govindan, D.M. Goldenberg, S.E. Elsamra, G.L. Griffiths, G.L. Ong, and M.W. Brechbiel Radionuclides linked to a CD74 antibody as therapeutic agents for B-cell lymphoma: comparison of Auger electron emitters with β-particle emitters J Nucl Med 41 2000 2089 2097
2. R.B. Michel, M.W. Brechbiel, and M.J. Mattes A comparison of four radionuclides conjugated to antibodies for single-cell kill J Nucl Med 44 2003 632 640
3. 90Y Clin Cancer Res 7 2001 1505 1510
4. R.B. Michel, A.V. Rosario, P.M. Andrews, D.M. Goldenberg, and M.J. Mattes Therapy of small s.c. B-lymphoma xenografts with antibodies conjugated to radionuclides emitting low-energy electrons Clin Cancer Res 11 2005 777 786
5. K.S.R. Sastry, C. Haydock, A.M. Basha, and D.V. Rao Electron dosimetry for radioimmunotherapy: optimal electron energy Radiat Prot Dosimetry 13 1985 249 252
6. G.L. Ong, S.E. Elsamra, D.M. Goldenberg, and M.J. Mattes Single-cell cytotoxicity with radiolabeled antibodies Clin Cancer Res 7 2001 192 201
7. R.B. Michel, M.E. Castillo, P.M. Andrews, and M.J. Mattes In vitro toxicity of A-431 carcinoma cells with antibodies to EGFr and EGP-1 conjugated to radionuclides emitting low-energy electrons Clin Cancer Res 10 2004 5957 5966
8. R.B. Michel, P.M. Andrews, M.E. Castillo, and M.J. Mattes In vitro cytotoxicity of carcinoma cells with III In-labeled antibodies to HER-2 Molec Cancer Ther 2005 [in press]
9. R.W. Howell Radiation spectra for Auger-electron emitting radionuclides: Report No. 2 of AAPM Nuclear Medicine Task Group No. 6 Med Phys 19 1992 1371 1383
10. J.B. Stimmel, and F.C.J. Kull Samarium-153 and lutetium-177 chelation properties of selected macrocyclic and acyclic ligands Nucl Med Biol 25 1998 117 125
11. S. Ponchon, F. Buchegger, A. Pelegrin, J.-P. Mach, R.E. Offord, and J.E. Ryser A novel derivative of the chelon desferrioxamine for site-specific conjugation to antibodies Int J Cancer 43 1989 1188 1194
12. 67Ga-labeled antibodies for immunoscintigraphy and evaluation of tumor targeting of drug-antibody conjugates in mice Cancer Res 48 1988 1189 1194
13. T. Furukawa, Y. Fujibayashi, M. Fukunaga, T. Saga, K. Endo, and A. Yokoyama An approach for immunoradiometric assay with metallic radionuclides: gallium-67-deferoxamine-dialdehyde starch-IgG J Nulc Med 32 1991 825 829
14. 67Ga-deferoxamine-folate, a potential radiopharmaceutical for tumor imaging Bioconjug Chem 7 1996 56 62
15. W.E. Meijs, H.J. Haisma, R.P. Klok, F.B. van Gog, E. Kievit, and H.M. Pinedo Zirconium-labeled monoclonal antibodies and their distribution in tumor-bearing nude mice J Nucl Med 38 1997 112 118
16. R. Stein, S.V. Govindan, M.J. Mattes, S. Chen, L. Reed, and G. Newsome Improved iodine radiolabels for monoclonal antibody therapy Cancer Res 63 2003 111 118
17. S. Patel, R. Stein, G.L. Ong, D.M. Goldenberg, and M.J. Mattes Enhancement of tumor-to-non-tumor localization ratios by hepatocyte-directed blood clearance of antibodies labeled with certain residualizing radiolabels J Nucl Med 40 1999 1392 1401
18. H.J. Hansen, G.L. Ong, H. Diril, P.A. Roche, G.L. Griffiths, and D.M. Goldenberg Internalization and catabolism of radiolabeled antibodies to the MHC class II invariant chain by B-cell lymphomas Biochem J 320 1996 293 300
19. M.A. Green, and M.J. Welch Gallium radiopharmaceutical chemistry Nucl Med Biol 5 1989 435 448
20. L.B. Shih, S.R. Thorpe, G.L. Griffiths, H. Diril, G.L. Ong, and H.J. Hansen The processing and fate of antibodies and their radiolabels bound to the surface of tumor cells in vitro: a comparison of nine radiolabels J Nucl Med 35 1994 899 908
21. R.J. Kyriakos, L.B. Shih, G.L. Ong, K. Patel, D.M. Goldenberg, and M.J. Mattes The fate of antibodies bound to the surface of tumor cells in vitro Cancer Res 52 1992 835 842
22. R.B. Michel, R. Ochakovskaya, and M.J. Mattes Antibody localization to B-cell lymphoma xenografts in immunodeficient mice: importance of using residualizing radiolabels Clin Cancer Res 8 2002 2632 2639
23. R. Stein, D.M. Goldenberg, S.R. Thorpe, A. Basu, and M.J. Mattes Effects of radiolabeling monoclonal antibodies with a residualizing iodine radiolabel on the accretion of radioisotope in tumors Cancer Res 55 1995 3132 3139
24. 67Ga Nucl Med Biol 25 1998 261 265
25. C. Caraco, L. Aloj, and W.C. Eckelman The gallium-deferoxamine complex: stability with different deferoxamine concentrations and incubation conditions Appl Radiat Isot 49 1998 1477 1479
26. H. Karacay, G.L. Ong, H.J. Hansen, G.L. Griffiths, D.M. Goldenberg, and M.J. Mattes Intracellular processing of technetium-99m-antibody conjugates Nucl Med Commun 19 1998 971 979
27. 89Zr-labeled monoclonal antibodies J Nucl Med 44 2002 1271 1281
28. 131I-labeled antibodies in mice bearing antibody internalizing and non-internalizing tumors Nucl Med Biol 19 1992 809 824
29. C.J. Mathias, Y. Sun, M.J. Welch, J.M. Connett, G.W. Philpott, and A.E. Martell N,N′-bis(2-hydroxybenzyl)-1-(4-bromoacetamidobenzyl)-1,2-ethylene- diamine-N,N′-diacetic acid: a new bifunctional chelate for radiolabeling antibodies Bioconjug Chem 1 1990 204 211
30. L.G. Luyt, and J.A. Katzenellenbogen A trithiolate tripodal bifunctional ligand for the radiolabeling of peptides with gallium (III) Bioconjug Chem 13 2002 1140 1145
31. 67Ga-labeled antibody via 1B4M or C-NOTA chelates Nucl Med Biol 24 1997 225 230