Effects of all-trans retinoic acid on expression of connexin genes and gap junction communication in hepatocellular carcinoma cell lines

National Medical Journal of China

Volumn 85, Issue 20, 2005, Pages 1414-1418

  Liu, Ying Bin ^a   Xu, Bin ^b   Wang, Jian Wei ^b   Fang, He Qing ^b   Li, Jiang Tao ^b   Li, Hai Jun ^b   Tang, Zhe ^b   Qian, Hao Ran ^b   Feng, Xue Dong ^b   Peng, Shu You ^b  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b NONE

Author keywords

Carcinoma, hepatocellular; Gap junction intercellular communication; Tretinoin

Indexed keywords

CONNEXIN 26; CONNEXIN 32; CONNEXIN 43; GAP JUNCTION PROTEIN; LUCIFER YELLOW; MESSENGER RNA; RETINOIC ACID;

ARTICLE; CELL COMMUNICATION; CONTROLLED STUDY; CULTURE MEDIUM; DRUG EFFECT; GAP JUNCTION; GENE EXPRESSION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION INITIATION SITE; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CARCINOMA, HEPATOCELLULAR; CELL COMMUNICATION; CELL LINE, TUMOR; CONNEXIN 43; CONNEXINS; GAP JUNCTIONS; HUMANS; LIVER NEOPLASMS; RNA, MESSENGER; TRETINOIN;

EID: 20744451928     PISSN: 03762491     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Krutovskikh V, Mazzoleni G, Mironov N, et al. Altered homologous and heterologus gap-junction intercellular communication in primary human liver tumors associatied with aberrant protein localization but not gene mutation of connexin32. Int J Cancer, 1994, 56: 87.
2. Omori Y, Krutovskikh V, Mironov N, et al. CX32 gene mutation in a chemical induced rat liver tumor. Carcinogenesis, 1996, 17: 2007.
3. Lee SW, Tomasetto C, Paul D, et al. Transcription downregulation of gap-junction proteins blocks junctional communication in human mammary tumor cell lines. J Cell Biol, 1992, 118: 1213-1221.
4. Yamasaki H, Naus CG. Role of connexin genes in growth control. Carcinogenesis, 1996, 17: 1199-1213.
5. Mehta P, Bertram J, Lowenstein W. Growth inhibition of transformed cells correlates with their junction communication with cells. Cell, 1986, 44: 187-196.
6. Zhang ZQ, Zhang W, Wang NQ, et al. Suppression of tumorigenicity of human carcinoma cells after transfection with connexin43. Carcinogenesis, 1998, 19: 1889-1894.
7. Bruzzone R, White TW, Paul DL. Connections with connexins: the molecular basis of direct intercellular signaling. Eru J Biochem, 1996, 238: 1-27.
8. Zhang JT, Nicholson BJ. The topological structure of connexin 26 and its distribution compared to connexin32 in hepatic gap junction. J Membr Biol, 1994, 139: 15-29.
9. Hossain M, Wilkens L, Parmender M, et al. Enhancement of gap junction communication by retinoids correlates with their ability to inhibit neoplastic transforeation. Carcinogenesis, 1989, 10: 1743-1748.
10. Mohamed H, Fouly EL, James E. Scrape-loading and dye transfer: a rapid and simple technique to study gap junction intercellular communication. Exp Cell Res, 1987, 168: 422-430.
11. Ara C, Massimi M, Conti Devirgiliis L. Retinoic acid modulates gap junction intercellular communication in hepatocytes and hepatoma cells. CMLS Cell Mol Life Sci, 2002, 59: 1758-1765.