Development of a small-animal PET system

Proceedings of the IEEE

Volumn 93, Issue 4, 2005, Pages 763-770

  Ziegler, Sibylle I ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Animal positron emission tomography (PET); Avalanche photodiodes (APDs); List mode reconstruction; Monte Carlo

Indexed keywords

AVALANCHE DIODES; BIOTECHNOLOGY; CRYSTALS; DISEASES; IMAGE RECONSTRUCTION; MAGNETIC RESONANCE IMAGING; MONTE CARLO METHODS; PHOTODIODES; SCINTILLATION;

ANIMAL POSITRON EMISSION TOMOGRAPHY (PET); AVALANCHE PHOTODIODES (APD); LIST MODE RECONSTRUCTION; MONTE CARLO; SPATIAL RESOLUTION;

POSITRON EMISSION TOMOGRAPHY;

EID: 20744437120     PISSN: 00189219     EISSN: None     Source Type: Journal    
DOI: 10.1109/JPROC.2005.844618     Document Type: Conference Paper

References (26)

1. P. E. Valk, D. L. Bailey, D. W. Townsend, and M. N. Maisey, Positron Emission Tomography: Basic Science and Clinical Practice. Heidelberg, Germany: Springer-Verlag, 2003.
2. S. P. Hume, R. N. Gunn, and T. Jones, "Pharmacological constraints associated with positron emission tomographic scanning of small laboratory animals," Eur. J. Nucl. Med., vol. 25, pp. 173-176, 1998.
3. M. Defrise, P. E. Kinahan, D. W. Townsend, C. Michel, M. Sibomana, and D. F. Newport, "Exact and approximate rebinning algorithms for 3-D PET data," IEEE Trans. Med. Imag., vol. 16, no. 2, pp. 145-158, Apr. 1997.
4. A. F. Chatziioannou, S. R. Cherry, Y. Shao, R. W. Silverman, K. Meadors, T. H. Farquhar, M. Pedarsani, and M. E. Phelps, "Performance evaluation of microPET: A high-resolution lutetium oxy-orthosilicate PET scanner for animal imaging," J. Nucl. Med., vol. 40, pp. 1164-1175, 1999.
5. C. Knoess, S. Siegel, A. Smith, D. F. Newport, N. Richerzhagen, A. Winkeler, A. Jacobs, R. N. Goble, R. Graf, K. Wienhard, and W. D. Heiss, "Performance evaluation of the microPET R4 PET scanner for rodents," Eur. J. Nucl. Med. Mol. Imaging, vol. 30, pp. 737-747, 2003.
6. Y.-C. Tai, A. F. Chatziioannou, Y. Yang, R. W. Silverman, K. Meadors, S. Siegel, D. F. Newport, J. R. Stickel, and S. R. Cherry, "MicroPET II: Design, development and initial performance of an improved microPET scanner for small-animal imaging," Phys. Med. Biol., vol. 48, pp. 1519-1537, 2003.
7. Y. Yang, Y.-C. Tai, S. Siegel, D. F. Newport, B. Bai, Q. Li, R. M. Leahy, and S. R. Cherry, "Optimization and performance evaluation of the microPET II scanner for in vivo small-animal imaging," Phys. Med. Biol., vol. 49, pp. 2527-2545, 2004.
8. S. Surti, J. S. Karp, A. E. Perkins, R. Freifelder, and G. Muehllehner, "Design evaluation of A-PET: A high sensitivity animal PET camera," IEEE Trans. Nucl. Sci., vol. 50, no. 5, pp. 1357-1363, Oct. 2003.
9. A. DelGuerra, G. DiDomenico, M. Scandola, and G. Zavattini, "YAP-PET: First results of a small animal positron emission tomograph based on YAP:Ce finger crystals," IEEE Trans. Nucl. Sci., vol. 45, no. 6, pp. 3105-3108, Dec. 1998.
10. J. Seidel, J. J. Vaquero, and M. V. Green, "Resolution uniformity and sensitivity of the NIH ATLAS small animal PET scanner: Comparison to simulated LSO scanners without depth-of-interaction capability," IEEE Trans. Nucl. Sci., vol. 50, no. 5, pp. 1347-1350, Oct. 2003.
11. R. Lecomte, J. Cadorette, S. Rodrigue, D. Lapointe, D. Rouleau, M. Bentourkia, R. Yao, and P. Msaki, "Initial results from the Shenbrooke avalanche photodiode positron tomograph," IEEE Trans. Nucl. Sci., vol. 43, no. 3, pp. 1952-1957, Jun. 1996.
12. A. P. Jeavons, R. A. Chandler, and C. A. R. Dettmar, "A 3D HIDAC-PET camera with sub-millimeter resolution for imaging small animals," IEEE Trans. Nucl. Sci., vol. 46, no. 3, pp. 468-473, Jun. 1999.
13. J. Missimer, Z. Madi, M. Honer, C. Keller, A. Schubiger, and S.-M. Ametamey, "Performance evaluation of the 16-module quad-HIDAC small animal PET camera," Phys. Med. Biol., vol. 49, pp. 2069-2081, 2004.
14. S. I. Ziegler, B. J. Pichler, G. Boening, M. Rafecas, W. Pimpl, E. Lorenz, N. Schmitz, and M. Schwaiger, "A prototype high resolution animal positron tomograph with avalanche photodiode arrays and LSO crystals," Eur. J. Nucl. Med., vol. 28, pp. 136-143, 2001.
15. 18F labeled RDG-containing glycopeptide and positron emission tomography," Cancer Res., vol. 61, pp. 1781-1785, 2001.
16. G. Boning, B. J. Pichler, M. Rafecas, E. Lorenz, M. Schwaiger, and S. I. Ziegler, "Implementation of Monte Carlo coincident aperture functions in image generation of a high resolution animal positron tomograph," IEEE Trans. Nucl. Sci., vol. 48, no. 3, pp. 805-810, Jun. 2001.
17. L. Parra and H. H. Barrett, "List-mode likelihood: EM algorithm and image quality estimation demonstrated on 2-D PET," IEEE Trans. Med. Imag., vol. 17, no. 2, pp. 228-235, Apr. 1998.
18. M. Rafecas, G. Böning, B. J. Pichler, E. Lorenz, M. Schwaiger, and S. I. Ziegler, "Effect of noise in the probability matrix used for statistical reconstruction of PET data," IEEE Trans. Nucl. Sci., vol. 51, no. 1, pp. 149-156, Feb. 2004.
19. B. J. Pichler, F. Bernecker, G. Boening, M. Rafecas, W. Pimpl, M. Schwaiger, E. Lorenz, and S. I. Ziegler, "A 4 × 8 APD array, consisting of two monolithic silicon wafers, coupled to a 32-channel LSO matrix for high-resolution PET," IEEE Trans. Nucl. Sci., vol. 48, no. 4, pp. 1391-1396, Aug. 2001.
20. B. J. Pichler, W. Pimpl, W. Buttler, G. Böning, M. Rafecas, E. Lorenz, and S. I. Ziegler, "Integrated low noise, low power, fast charge-sensitive preamplifier for avalanche photodiodes in JFET-CMOS-technology, " IEEE Trans. Nucl. Sci., vol. 48, no. 6, pp. 2370-2374, Dec. 2001.
21. D. P. McElroy, W. Pimpl, M. Djelassi, B. J. Pichler, M. Rafecas, T. Schüler, and S. I. Ziegler, "First results from MADPET-II: A novel detector and readout system for high resolution small animal PET," presented at the IEEE Medical Imaging Conf., Portland, OR, 2003.
22. "GEANT 3.21: Detector description and simulation tool," CERN, Geneva, Switzland, CERN Program Library Long Writeup W5013, 1993.
23. M. Rafecas, G. Böning, B. J. Pichler, E. Lorenz, M. Schwaiger, and S. I. Ziegler, "A Monte Carlo study of high resolution PET with granulated dual layer detectors," IEEE Trans. Nucl. Sci., vol. 48, no. 4, pp. 1490-1495, Aug. 2001.
24. M. E. Casey and R. Nutt, "Multicrystal two dimensional BGO detector system for positron emission tomography," IEEE Trans. Nucl. Sci., vol. 33, no. 1, pp. 460-463, Feb. 1986.
25. M. Rafecas, G. Boning, B. J. Pichler, E. Lorenz, M. Schwaiger, and S. I. Ziegler, "Inter-crystal scatter in a dual layer, high resolution LSO-APD positron emission tomograph," Phys. Med. Biol., vol. 48, pp. 821-848, 2003.
26. M. Rafecas, B. Mosler, M. Dietz, M. Pögl, A. Stamatakis, D. P. McElroy, and S. I. Ziegler, "Use of a Monte Carlo-based probability matrix for 3-D iterative reconstruction of MADPET-II data," IEEE Trans. Nucl. Sci., no. 5, pp. 2597-2605, Oct. 2004.