mRNA splicing in Trypanosoma brucei: Branch-point mapping reveals differences from the canonical U2 snRNA-mediated recognition

Molecular and Biochemical Parasitology

Volumn 142, Issue 2, 2005, Pages 248-251

  Lücke, Stephan ^a,c   Jürchott, Kathrin ^b   Hung, Lee Hsueh ^a   Bindereif, Albrecht ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b German Genome Resource Center RZPD   (Germany)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Splicing; Trypanosomes

Indexed keywords

MESSENGER RNA; SMALL NUCLEAR RNA;

ARTICLE; CONTROLLED STUDY; GENE MAPPING; GENE SEQUENCE; MOLECULAR RECOGNITION; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN MOTIF; PROTOZOAL GENETICS; RNA SPLICING; RNA STRUCTURE; TRYPANOSOMA BRUCEI;

ANIMALS; BASE SEQUENCE; MOLECULAR SEQUENCE DATA; PROTOZOAN PROTEINS; RNA SPLICING; RNA, MESSENGER; RNA, SMALL NUCLEAR; TRYPANOSOMA BRUCEI BRUCEI;

TRYPANOSOMA BRUCEI;

EID: 20644446866     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2005.04.007     Document Type: Article

References (16)

1. E. Ullu, C. Tschudi, and A. Günzl Trans-splicing in trypanosomatid protozoa D.F. Smith M. Parsons Molecular biology of parasitic protozoa 1996 IRL Press Oxford 115 133
2. C.E. Clayton Life without transcriptional control? From fly to man and back again EMBO J 21 2002 1881 1888
3. X.H. Liang, A. Haritan, S. Uliel, and S. Michaeli Trans and cis splicing in trypanosomatids: mechanism, factors, and regulation Eukaryot Cell 2 2003 830 840
4. G. Mair, H. Shi, and H. Li A new twist in trypanosome RNA metabolism: cis-splicing of pre-mRNA RNA 6 2000 163 169
5. M. Spingola, L. Grate, D. Haussler, and M. Ares Jr. Genome-wide bioinformatic and molecular analysis of introns in Saccharomyces cerevisiae RNA 5 1999 221 234
6. K. Hartmuth, and A. Barta Unusual branch point selection in processing of human growth hormone pre-mRNA Mol Cell Biol 8 1988 2011 2020
7. M. Goux-Pelletan, D. Libri, Y. d'Aubenton-Carafa, M. Fiszman, E. Brody, and J. Marie In vitro splicing of mutually exclusive exons from the chicken beta-tropomyosin gene: role of the branch point location and very long pyrimidine stretch EMBO J 9 1990 241 249
8. M.R. Green Pre-mRNA splicing Annu Rev Genet 20 1986 671 708
9. C. Tschudi, S.P. Williams, and E. Ullu Conserved sequences in the U2 snRNA-encoding genes of kinetoplastida do not include the putative branchpoint recognition region Gene 91 1990 71 77
10. T. Hartshorne, and N. Agabian A new U2 RNA secondary structure provided by phylogenetic analysis of trypanosomatid U2 RNAs Genes Dev 4 1990 2121 2131
11. E. Patzelt, K.L. Perry, and N. Agabian Mapping of branch sites in trans-spliced pre-mRNAs of Trypanosoma brucei Mol Cell Biol 9 1989 4291 4297
12. J. Vogel, W.R. Hess, and T. Börner Precise branch point mapping and quantification of splicing intermediates Nucleic Acids Res 25 1997 2030 2031
13. K.K. Nelson, and M.R. Green Mammalian U2 snRNP has a sequence-specific RNA-binding activity Genes Dev 3 1989 1562 1571
14. T.D. Schneider, and R.M. Stephens Sequence logos: a new way to display consensus sequences Nucleic Acids Res 18 1990 6097 6100
15. M. Vázquez, C. Atorrasagasti, N. Bercovich, R. Volcovich, and M.J. Levin Unique features of the Trypanosoma cruzi U2AF35 splicing factor Mol Biochem Parasitol 128 2003 77 81
16. C.L. Kielkopf, S. Lücke, and M.R. Green U2AF homology motifs: protein recognition in the RRM world Genes Dev 18 2004 1513 1526