A quantitative structure-activity relationship study on some Na+ and K+ channel blockers: Role of molecular connectivity index

Letters in Drug Design and Discovery

Volumn 2, Issue 4, 2005, Pages 287-290

  Gupta, S P ^a   Paleti, Anitha ^a   Mekapati, S B ^a   Nagappa, A N ^a   Kumaran, S ^a  

^a BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

Author keywords

Connectivity index; K+ channel blockers; Na+ channel blockers; QSAR

Indexed keywords

ACETAMIDE DERIVATIVE; ANESTHETIC AGENT; ANTIARRHYTHMIC AGENT; ANTICONVULSIVE AGENT; BENZODIAZEPINE DERIVATIVE; DIPHENYLACETAMIDE DERIVATIVE; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; SODIUM CHANNEL; SODIUM CHANNEL BLOCKING AGENT; UNCLASSIFIED DRUG; VERATRIDINE;

ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; GUINEA PIG; HEART MUSCLE CELL; IC 50; MOLECULAR SIZE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; VOLTAGE CLAMP;

EID: 20644441014     PISSN: 15701808     EISSN: None     Source Type: Journal    
DOI: 10.2174/1570180054038422     Document Type: Article

References (10)

1. Catterall, W. A. Trends Pharmacol. Sci., 1987, 8, 57.
2. nd Ed., Sinauer Associates, Inc., Suderland, MA, 1992.
3. Vaughan Williams, E. M. J. Clin. Pharmacol., 1984, 24, 129.
4. Jurkiewicz, N. K.; Sanguinetti, M. C. Circ. Res., 1993, 72, 75.
5. Hondeghem, L. M. J. Cardivasc. Pharmacol., 1995, 20 (suppl.), 17.
6. Kier, L. B. and Hall L. H., Molecular Connectivity in Chemistry and Drug Research: Academic Press: New York, 1976.
7. Roufos, I.; Hays, S.; Schwarz, R. D. J. Med. Chem., 1996, 39, 1514.
8. Selnick, H. G.; Liverton, N. J.; Baldwin, J. J.; Butcher, J. W.; Claremon, D. A.; Elliot, J. M.; Friedinger, R. M.; King, S. A.; Libby, B. E.; McIntyre, C. J.; Pribush, D. A.; Remy, D. C.; Smith, G. R.; Tebber, A. J.; Jurkiewicz, N. K.; Salatta, J. J.; Sanguinetti, M. C.; Siegl, P. K. S.; Slaughter, D. E.; Vyas, K. J. Med. Chem., 1997, 40, 3865.
9. Kier, L. B.; Hall, L. H. J. Pharm. Sci., 1983, 72, 1170.
10. Gupta, S. P. Chem. Rev., 1991, 91, 1109.