Ratios of N-(2,3,4-trihydroxybutyl) valine and N-(2-hydroxy-3-butenyl) valine formed hemoglobin adducts in female mice inhalation exposure with 1,3-butadiene

Toxicology and Industrial Health

Volumn 21, Issue 10, 2005, Pages 15-20

  Lee, Jin Heon ^a   Kang, Hee Sook ^a   Han, Don Hee ^b  

^a Kongju National University   (South Korea)

^b Inje University   (South Korea)

Author keywords

(N 2,3,4 trihydroxy butyl)valine (THB Val adduct); (N 2 hydroxy 3 butenyl)valine (HB Val adduct); 1,3 butadiene (BD); biomarker; GC MS

Indexed keywords

1,3 BUTADIENE; BIOLOGICAL MARKER; CARCINOGEN; HEMOGLOBIN; N (2 HYDROXY 3 BUTENYL)VALINE; N (2,3,4 TRIHYDROXYBUTYL)VALINE; UNCLASSIFIED DRUG; VALINE;

ANIMAL EXPERIMENT; ARTICLE; BIOLOGICAL MONITORING; BODY WEIGHT; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; EXPOSURE; FEMALE; MOUSE; NONHUMAN; PETROCHEMICAL INDUSTRY; QUANTITATIVE ASSAY; WEIGHT REDUCTION;

ADMINISTRATION, INHALATION; ANIMALS; ATMOSPHERE EXPOSURE CHAMBERS; BIOLOGICAL MARKERS; BODY WEIGHT; BUTADIENES; CARCINOGENS; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HEMOGLOBINS; MICE; MICE, INBRED ICR; VALINE;

RODENTIA;

EID: 20644440830     PISSN: 07482337     EISSN: None     Source Type: Journal    
DOI: 10.1191/0748233705th210oa     Document Type: Article

References (23)

1. Albertini, R. J., Sram, R. J., Vacek, P. M. et al. 2001: Biomarkers for assessing occupational exposures to 1,3-butadiene. Chemico-Biological Interactions 135-136, 429-453.
2. Albrecht, O. E., Filser, J. E. and Neumann, H. G. 1993: Biological monitoring of 1,3-butadiene: species differences in hemoglobin binding in rats and mouse, in butadiene and styrene: assessment of health hazards. Lyon: IARC Scientific Publications, 135-142.
3. Bernard, A. and Lauwerys, R. 1986: Present status and trends in biological monitoring of exposure to industrial chemicals. Journal of Occupational Medicine 28, 558-562.
4. Boogad, P. J., Van Sittert, N. J. and Megens, H. J. 2001: Urinary metabolites and hemoglobin adducts as biomarkers of exposure to 1,3-butadiene: a basis for 1,3-butadiene cancer risk assessment, Chemico-Biological Interactions 135-136, 695-701.
5. Committee of Biological Markers of the National Research Council. 1987: Biological markers in environmental health research. Environmental Health Perspectives 74, 3-9.
6. Department of Health and Human Services (US). 2000: 1,3-Butadiene. In the ninth report on carcinogens. Research Triangle Park, NC: National Toxicology Program.
7. Deutsche Forschungsgemeinschaft. 2002: List of MAK and BAT values. Commission for the Investigation of Health Hazard of Chemicals Compounds in the Work Area, Report No. 35. Weinheim: Wiley-VCH.
8. Environmental Protection Agency (US). 2002: Health risk assessment of 1,3-butadiene. EPA/600/P-98/001F. Washington, DC: National Office for Environmental Assessment-Washington Office, Office of Research and Development, US EPA.
9. Fustinoni, S., Perbellini, L., Soleo, L. et al. 2004: Biological monitoring in occupational exposure to low levels of 1,3- butadiene. Toxicology Letters 1149, 353-360.
10. Henderson, R. F., Bechtold, W. E. and Sabourin, P. J. 1993: Species differences in the metabolism of 1,3-butadiene in vivo. In Sorsa, M., Poltonen, K., Vainio, H. and Hemminki, K., editors, Butadiene and styrene: assessment of health hazards. IARC Scientific Publications, 127, 57-64.
11. Huff, J. E., Melnick, R. L., Solleveld, H. A. et al. 1985: Multiple organ carcinogenicity of 1,3-butadiene in B6C3F1 mice after 60 weeks of inhalation exposure, Science (Washington, D.C.) 227, 548-549.
12. IARC. 1999: 1,3-Butadiene, IARC monographs on the evaluation of carcinogenic risks to humans. IARC Scientific Publications, 71, 109-109.
13. Himmelstein, M. W., Acquavella, J. F., Recio, L. et al. 1997: Toxicology and epidemiology of 1,3-butadiene. Critical Reviews in Toxicology 27, 1-108.
14. Lauwerys, R. R. and Hoet, P. 1993: Industrial chemical exposure-guidelines for biological monitoring, second edition. Roca Raton, USA: Lewis Publishers, 1-13.
15. Lee, J. H. and Shin, H. S. 2002: Determination of hemoglobin adducts formed in rats exposed orally with 3,3?-dichlorobenzidine by GC/MS-SIM. Toxicology and Industrial Health 18, 191-199.
16. Melnick, R. L., Huff, J., Chou, J. and Miller, R. A. 1990: Carcinogenicity of 1,3-butadiene in B6C3F1 mice at low exposure concentrations. Cancer Research 50, 6592-6599.
17. Osterman-Golkar, S., Peltonen, K., Anttinen-Klemetti, T. et al. 1996: Hemoglobin adducts as biomarkers of occupational exposure to 1,3-butadiene. Mutagenesis 10, 145-149.
18. Osterman-Golkar, M., Moss, O., James, A. et al. 1998: Epoxybutene-hemoglobin adducts in rat and mice: dose response for formation and persistence during and following long-term low-level exposure to butadiene. Toxicology and Applied Pharmacology 150, 166-173.
19. Owen, P. E., Glaister, J. R., Gaunt, I. F. and Pullinger, D. H. 1987: Inhalation toxicity studies with 1,3-butadiene. III. Two years toxicity/carcinogenicity study in rats. American Industrial Hygiene Association Journal 48, 407-413.
20. Perez, H. L., Lahdetie, J., Landin, H. H. et al. 1997: Hemoglobin adducts of epoxybutanediol from exposure to 1,3- butadiene or butadiene epoxides. Chemico-Biological Interactions 105, 181-198.
21. Swenberg, J. A., Christova G., Upton, N. I. et al. 2000: 1,3-Butadiene: cancer mutation and adducts. Part V: Hemoglobin adducts as biomarker of 1,3-butadiene exposure and metabolism. Research Report/Health Effectives Institute 92, 191-210.
22. Swenberg, J. A., Koc, H., Upton, P. B. et al. 2001: Using DNA and hemoglobin adducts to improve the risk assessment of butadiene. Chemico-Biological Interactions 135-136, 387-403.
23. Van Putten, L. M. 1958: The life span of red cells in the rats and the mouse as determined by labeling with DFP32 in vivo. Blood 13, 789-794.