Urinary metabolites and haemoglobin adducts as biomarkers of exposure to 1,3-butadiene: A basis for 1,3-butadiene cancer risk assessment

Chemico-Biological Interactions

Volumn 135-136, Issue , 2001, Pages 695-701

  Boogaard, Peter J ^a,b   Van Sittert, Nico J ^a   Megens, Hendricus J J J ^a  

^a SHELL RESEARCH AND TECHNOLOGY CENTRE   (Netherlands)

^b SHELL GLOBAL SOLUTIONS INTERNATIONAL B V   (United States)

Author keywords

1,3 Butadiene; Biomarkers; Exposure monitoring; Haemoglobin adducts; Risk assessment; Urinary metabolites

Indexed keywords

1 HYDROXY 3 BUTENYL VALINE; 1 MONOHYDROXY 3 BUTENYL MERCAPTURIC ACID; 1,2 DIHYDROXYBUTYL MERCAPTURIC ACID; 1,3 BUTADIENE; 2 HYDROXY 3 BUTENYL VALINE; 2 MONOHYDROXY 3 BUTENYL MERCAPTURIC ACID; ACETYLCYSTEINE DERIVATIVE; BIOLOGICAL MARKER; DNA; HEMOGLOBIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; BLOOD LEVEL; CANCER RISK; COMPARATIVE STUDY; CONFERENCE PAPER; CONTROLLED STUDY; EXPERIMENTAL ANIMAL; GENOTOXICITY; HUMAN; HYDROLYSIS; IN VITRO STUDY; MALE; METABOLISM; METABOLITE; MOUSE; NONHUMAN; NORMAL HUMAN; OCCUPATIONAL EXPOSURE; RAT; RISK ASSESSMENT; URINE LEVEL; WORKER;

AIR POLLUTANTS, OCCUPATIONAL; ANIMALS; BIOLOGICAL MARKERS; BUTADIENES; CARCINOGENS; CHEMICAL INDUSTRY; CZECH REPUBLIC; HEMOGLOBINS; HUMANS; MALE; NETHERLANDS; OCCUPATIONAL EXPOSURE; RISK ASSESSMENT;

ANIMALIA; RODENTIA;

EID: 17044458930     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(01)00205-8     Document Type: Conference Paper

References (11)

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3. Biological monitoring of exposure to benzene: A comparison between S-phenylmercapturic acid, trans,trans-muconic acid and phenol
4. Biomonitoring of exposure to ethylene oxide and propylene oxide by determination of hemoglobin adducts: Correlations between airborne exposure and adduct levels
5. Monitoring occupational exposure to some industrial chemicals by determining hemoglobin adducts
6. Species differences in urinary butadiene metabolites: Identification of 1,2-dihydroxy-4-(N-acetylcysteinyl)-butane, a novel metabolite from 1,3-butadiene
7. Species differences in urinary butadiene metabolites: Comparisons of metabolite ratios between mice, rats and humans
8. Biomarkers of exposure to 1,3-butadiene as a basis for cancer risk assessment
9. Biological monitoring of butadiene exposure by measurement of hemoglobin adducts
10. The role of hydrolysis in the detoxification of 1,2:3,4-diepoxybutane by human, rat, and mouse liver and lung in vitro
11. N7-(1-(Hydroxymethyl)-2,3-dihydroxypropyl)guanine is the major DNA adduct after exposure to 1,3-butadiene but not 1,2-epoxy-3-butene